1. Immunology/Inflammation
  2. Toll-like Receptor (TLR)
  3. BBIQ

BBIQ 

Cat. No.: HY-111582
Handling Instructions

BBIQ is a imidazoquinoline compound and a potent and selectively toll-like receptor 7 (TLR7) agonist with an EC50 of  59.1 nM for human TLR7. BBIQ is a powerful vaccine adjuvant that enhances innate immune responses.

For research use only. We do not sell to patients.

BBIQ Chemical Structure

BBIQ Chemical Structure

CAS No. : 1229024-57-0

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Description

BBIQ is a imidazoquinoline compound and a potent and selectively toll-like receptor 7 (TLR7) agonist with an EC50 of  59.1 nM for human TLR7. BBIQ is a powerful vaccine adjuvant that enhances innate immune responses[1][2].

IC50 & Target[1]

TLR7

59.1 nM (EC50, Human TLR7)

In Vitro

BBIQ induces IFN-α in human PBMCs (520 pg/mL at 5 µg/mL)[1].

In Vivo

In mice treated with Chloroquine (CQ) alone, parasite (P. berghei ANKA) appearesd on Day 17 and all mice of this group died by Day 21. Whereas, mice treated with BBIQ along with CQ exhibits no appearance of parasite till Day 23. Frequencies of T cells (CD3+, CD4+and CD8+) and T regulatory cells (CD4+, CD25 +and FoxP3+) are lower in brain of BBIQ + CQ treated mice as compared to BBIQ alone and CQ alone treated mice on Day 10. Inhibition of infiltration of inflammatory T cells and activation of T helper and T cytotoxic cells against the parasite is observed in the mice treated with this combination therapy. Serum levels of IFN-γ and IL-12 are higher on same day in mice treated with BBIQ + CQ which reveals the generation of strong Th1 immune response in mice against the infection[1].

Molecular Weight

330.43

Formula

C₂₁H₂₂N₄

CAS No.

1229024-57-0

SMILES

NC1=NC2=CC=CC=C2C3=C1N=C(CCCC)N3CC4=CC=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

BBIQToll-like Receptor (TLR)MalariaantimalarialsvaccineTLR7imidazoquinolineIFN-γIL-12immuneresponseadjuvantInhibitorinhibitorinhibit

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