TLR2 antagonist-1
TLR2 antagonist-1 is a selective Toll-like receptor 2 (TLR2) antagonist. TLR2 antagonist-1 can effectively inhibit excessive TLR2 activation (IC50 = 11.41 μM) and the production of inflammatory factors. TLR2 antagonist-1 has metabolic stability with a half-life (T1/2) of 16.67 min in mouse liver microsomes. TLR2 antagonist-1 can be used for the researches of inflammation, immunology, and neurological disease.
For research use only. We do not sell to patients.
- Formula: C18H15ClFN3O4
- Molecular Weight:391.78
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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TLR2 11.41 μM (IC50) |
TLR2 antagonist-1 (Compound T30) exhibits low cytotoxicity with an CC50 value of 37.25 μM in RAW 264.7 cells[1].
TLR2 antagonist-1 (12.5-25 μM) inhibits hTLR2/NF-κB pathway in HEK-Blue hTLR2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 391.78
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Formula C18H15ClFN3O4
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SMILES
C/C(C1=CC=C(O)C(O)=C1Cl)=N\OCC2=CC(C3=NOC(C)=N3)=CC(F)=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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