Cholesterol oxidase, rhodococcus sp
Based on 2 publication(s) in Google Scholar
Cholesterol oxidase, rhodococcus sp (ChOx, rhodococcus sp) (EC 1.1.3.6) is a cholesterol oxidase identified from bacterial sources. Cholesterol oxidase, rhodococcus sp catalyzes the oxidation of cholesterol to 4-cholesten-3-one, while simultaneously reducing oxygen to hydrogen peroxide. Cholesterol oxidase, rhodococcus sp retains its enzymatic activity and exhibits improved catalytic efficiency upon immobilization. Cholesterol oxidase, rhodococcus sp is applicable for cholesterol detection, steroid biotransformation, and research on tuberculosis-related diseases.
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- CAS No.: 9028-76-6
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Biological Activity
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Chemical Information
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Biological Activity
Description
IC50 & Target
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TLR2 |
In Vitro
Cholesterol oxidase, rhodococcus sp is heterologously expressed in Escherichia coli, achieving an enzyme yield of 2150-2180 U/L and a specific activity of 2.2 U/mg protein[1].
Cholesterol oxidase, rhodococcus sp (17.65 U/mg; overnight) can be immobilized on silane-modified iron (II, III) oxide magnetic nanoparticles, achieving a maximum immobilization efficiency of 91%, and catalyzes the biotransformation of cholesterol into 4-cholesten-3-one[5].
Cholesterol oxidase, rhodococcus sp exhibits a Km of 16.7 mM and a Vmax of 0.25 mM/min in its free form, while immobilization reduces the Km to 8.3 mM and increases the Vmax to 0.31 mM/min, significantly improving its catalytic efficiency[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 9028-76-6
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SMILES
[Cholesterol oxidase, rhodococcus sp]
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Synonyms
ChOx, rhodococcus sp
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Shipping
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Mater Today Bio
"Top-down and Bottom-up" cholesterol-depleting biomimetic nanoparticle for enhancing sonodynamic therapy against hepatocellular carcinoma. [Abstract]2025 Sep 30:35:102370. PMID: 41104047 -
Purity & Documentation
References
[1]. Cui H, et al. Heterologous Expression and Function of Cholesterol Oxidase: A Review. Protein Pept Lett. 2023;30(7):531-540. [Content Brief]
[2]. Brzostek A, et al. Cholesterol oxidase is required for virulence of Mycobacterium tuberculosis. FEMS microbiology letters. 2007 Oct;275(1):106-12. [Content Brief]
[5]. Ghosh S, et al. Cholesterol-oxidase-magnetic nanobioconjugates for the production of 4-cholesten-3-one and 4-cholesten-3, 7-dione. Bioresource technology. 2018 Apr;254:91-96. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cholesterol oxidase, rhodococcus sp Related Classifications
HY-P2848A Related Classifications
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Keywords
- Cholesterol oxidase, rhodococcus sp
- 9028-76-6
- ChOx, rhodococcus sp
- Xanthine Oxidase
- silane-modified iron(II
- III)oxide magnetic nanoparticles
- tuberculosis
- flavin adenine dinucleotide
- 4-cholesten-3-one
- Rhodococcus sp.
- hydrogen peroxide
- cholesterol
- 4-cholesten-3,7-dione
- Cholesterol oxidase
- 7-ketocholesterol
- Inhibitor
- inhibitor
- inhibit