1. Immunology/Inflammation
  2. Toll-like Receptor (TLR)
  3. Loxoribine

Loxoribine (Synonyms: 7-Allyl-8-oxoguanosine; RWJ 21757)

Cat. No.: HY-108472
Handling Instructions

Loxoribine (7-Allyl-8-oxoguanosine) is a guanosine analog with anti-viral and anti-tumor activities. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist.

For research use only. We do not sell to patients.

Loxoribine Chemical Structure

Loxoribine Chemical Structure

CAS No. : 121288-39-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 90 In-stock
Estimated Time of Arrival: December 31
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 210 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Loxoribine (7-Allyl-8-oxoguanosine) is a guanosine analog with anti-viral and anti-tumor activities. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist[1][2][3].

IC50 & Target

TLR7[1]

In Vitro

Loxoribine induces maturation of human monocyte-derived dendritic cells DCs and stimulates their Th-1- and Th-17-polarizing capability[2].
Loxoribine (250 μM; 48 hours) stimulates maturation of MoDCs as shown by up-regulation of CD80, CD83, CD40, CD54 and CCR7[2].
loxoribine activates cells of the innate immune system selectively via the Toll-like receptor (TLR) 7/MyD88-dependent signaling pathway[1].

In Vivo

Loxoribine (2 mg; s.c.or i.v.) activates murine natural killer (NK) cells in vivo[3].

Animal Model: 8-12 weeks male CBA/J mice[3]
Dosage: 2 mg
Administration: Subcutaneous or intravenous injection
Result: activates murine natural killer (NK) cells in vivo.
Molecular Weight

339.30

Formula

C₁₃H₁₇N₅O₆

CAS No.

121288-39-9

SMILES

O=C1N([[email protected]@H]2O[[email protected]](CO)[[email protected]@H](O)[[email protected]]2O)C3=C(C(NC(N)=N3)=O)N1CC=C

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Loxoribine7-Allyl-8-oxoguanosine RWJ 21757RWJ21757RWJ 21757RWJ-21757Toll-like Receptor (TLR)TLR-7MoDCsnaturalkiller,cellsNKcellsInhibitorinhibitorinhibit

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Loxoribine
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HY-108472
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