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United States

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製品番号: HY-162163

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TLR7 agonist 19

TLR7 agonist 19 (Compound 14) is a Toll-like receptor 7 (TLR7) agonist with excellent pharmacokinetic properties and synergistic antitumor activity.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2682008-42-8
分子式: C₂₈H₄₂N₈O₃
分子量:538.68

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

TLR7 agonist 19 構造式

CAS 番号: 2682008-42-8

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

TLR7 agonist 19 (Compound 14) is a Toll-like receptor 7 (TLR7) agonist with excellent pharmacokinetic properties and synergistic antitumor activity.

Toll-like Receptor (TLR) アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
T-cell	IC₅₀	>25 μM Compound: 14	Cytotoxicity against PHA-activated T-cells (unknown origin) assessed as inhibition of IL-2 induced cell proliferation measured after 72 hrs by MTS assay Cytotoxicity against PHA-activated T-cells (unknown origin) assessed as inhibition of IL-2 induced cell proliferation measured after 72 hrs by MTS assay	[PMID: 38352849]

化学情報

CAS 番号 2682008-42-8
分子量 538.68
分子式 C₂₈H₄₂N₈O₃
SMILES

CCC[C@H](NC1=C(N(CC2=NC=C(C3CCN(C4CCOCC4)CC3)C=C2OC)N=C5)C5=NC(N)=N1)CCO
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (270 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. He L, et al. Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology[J]. ACS Medicinal Chemistry Letters, 2024.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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