7-Cyano-7-deaza-2'-deoxy guanosine
Based on 1 Customer Validation
7-Cyano-7-deaza-2'-deoxy guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7).
For research use only. We do not sell to patients.
- Purity : 99.70%
- CAS No.: 199859-58-0
- Formula: C12H13N5O4
- Molecular Weight:291.26
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Chemical Information
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CAS No. 199859-58-0
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Appearance Solid
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Molecular Weight 291.26
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Formula C12H13N5O4
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Color White to off-white
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SMILES
O[C@H]1C[C@H](N2C(NC(N)=NC3=O)=C3C(C#N)=C2)O[C@@H]1CO
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (343.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4334 mL | 17.1668 mL | 34.3336 mL | 85.8340 mL |
| 5 mM | 0.6867 mL | 3.4334 mL | 6.8667 mL | 17.1668 mL | |
| 10 mM | 0.3433 mL | 1.7167 mL | 3.4334 mL | 8.5834 mL | |
| 15 mM | 0.2289 mL | 1.1445 mL | 2.2889 mL | 5.7223 mL | |
| 20 mM | 0.1717 mL | 0.8583 mL | 1.7167 mL | 4.2917 mL | |
| 25 mM | 0.1373 mL | 0.6867 mL | 1.3733 mL | 3.4334 mL | |
| 30 mM | 0.1144 mL | 0.5722 mL | 1.1445 mL | 2.8611 mL | |
| 40 mM | 0.0858 mL | 0.4292 mL | 0.8583 mL | 2.1458 mL | |
| 50 mM | 0.0687 mL | 0.3433 mL | 0.6867 mL | 1.7167 mL | |
| 60 mM | 0.0572 mL | 0.2861 mL | 0.5722 mL | 1.4306 mL | |
| 80 mM | 0.0429 mL | 0.2146 mL | 0.4292 mL | 1.0729 mL | |
| 100 mM | 0.0343 mL | 0.1717 mL | 0.3433 mL | 0.8583 mL |
7-Cyano-7-deaza-2'-deoxy guanosine Related Classifications
HY-152992 Related Classifications
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