2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. MTT5

MTT5 is a toll-like receptor 7 (TLR7) agonist. MTT5 can couple with Deruxtecan (HY-13631E) and exert anti-tumor activity in HER2 positive solid tumors through tumor cell killing and immune activation.

For research use only. We do not sell to patients.

MTT5

MTT5 Chemical Structure

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MTT5 Related Antibodies

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

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Description

MTT5 is a toll-like receptor 7 (TLR7) agonist. MTT5 can couple with Deruxtecan (HY-13631E) and exert anti-tumor activity in HER2 positive solid tumors through tumor cell killing and immune activation[1].
IC50 & Target

TLR7

 

Molecular Weight

453.49

Formula

C22H27N7O4
Appearance

Solid

Color

White to off-white

SMILES

COCCOC1=NC(N)=C2NC(N(C2=N1)CC3=CC=C(C=C3)C(N4CC5CNCC5C4)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (55.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2051 mL 11.0256 mL 22.0512 mL
5 mM 0.4410 mL 2.2051 mL 4.4102 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2051 mL 11.0256 mL 22.0512 mL 55.1280 mL
5 mM 0.4410 mL 2.2051 mL 4.4102 mL 11.0256 mL
10 mM 0.2205 mL 1.1026 mL 2.2051 mL 5.5128 mL
15 mM 0.1470 mL 0.7350 mL 1.4701 mL 3.6752 mL
20 mM 0.1103 mL 0.5513 mL 1.1026 mL 2.7564 mL
25 mM 0.0882 mL 0.4410 mL 0.8820 mL 2.2051 mL
30 mM 0.0735 mL 0.3675 mL 0.7350 mL 1.8376 mL
40 mM 0.0551 mL 0.2756 mL 0.5513 mL 1.3782 mL
50 mM 0.0441 mL 0.2205 mL 0.4410 mL 1.1026 mL
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MTT5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MTT5MTT 5MTT-5Toll-like Receptor (TLR)TLR7tumor cell killingimmune activationHER2Inhibitorinhibitorinhibit

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