1. Immunology/Inflammation
  2. Toll-like Receptor (TLR)
  3. AZD8848

AZD8848 

Cat. No.: HY-111269
Handling Instructions

AZD8848 is a selective toll-like receptor 7 (TLR7) antedrug agonist which is developed for the research of asthma and allergic rhinitis.

For research use only. We do not sell to patients.

AZD8848 Chemical Structure

AZD8848 Chemical Structure

CAS No. : 866269-28-5

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Description

AZD8848 is a selective toll-like receptor 7 (TLR7) antedrug agonist which is developed for the research of asthma and allergic rhinitis[1].

IC50 & Target

TLR7[1]

In Vitro

AZD8848 shows good activity against TLR7, with cellular pEC50s of 7.0 and 6.6 for human TLR7 and rat TLR7, respectively[1].
AZD8848 has an EC50 of 4 nM in the induction of IFNα from human PBMCs and an IC50 of 0.2-1.0 nM for the inhibition of IL-5, irrespective of whether the T cells have been polyclonally stimulated with PHA or via antigen presentation[1].
AZD8848 is a potent, selective TLR7 agonist antedrug able to inhibit Th2 responses in vitro[1].
AZD8848 has no activity against human TLR8 or against any of the other human TLRs[1].

In Vivo

AZD8848 (0.1-1 mg/kg; intratracheal) has a good pharmacokinetics in the Brown Norway rat[1].
AZD8848 (0.3 mg/kg; Intratracheal) suppresses the ovalbumin (OVA) challenge in the rat allergy model[1].

Animal Model: Brown Norway rat allergy model[1]
Dosage: 0.1 mg/kg, 1 mg/kg
Administration: Intratracheal (24 hours prior to and 24 hours after the OVA challenge)
Result: Suppressed OVA challenge in a dose-dependent manner.
Animal Model: Brown Norway rat[1]
Dosage: 0.3 mg/kg (Pharmacokinetic Analysis)
Administration: Intratracheal
Result: Has a very short half-life (0.2 min) in rat blood and declined slowly after this point and levels above 1000 nmol/kg were maintained for over 5 hours.
Molecular Weight

569.70

Formula

C₂₉H₄₃N₇O₅

CAS No.

866269-28-5

SMILES

O=C(OC)CC1=CC=CC(CN(CCCN2C(NC3=C(N)N=C(OCCCC)N=C23)=O)CCCN4CCOCC4)=C1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

AZD8848AZD 8848AZD-8848Toll-like Receptor (TLR)toll-likereceptorTLR7antedrugasthmaallergicrhinitisAZ12432045Inhibitorinhibitorinhibit

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AZD8848
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