Search Result
Results for "
group VIA
" in MedChemExpress (MCE) Product Catalog:
63
Biochemical Assay Reagents
3
Isotope-Labeled Compounds
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Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-129832
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Biotin-azide
Maximum Cited Publications
8 Publications Verification
N-(3-Azidopropyl)biotinamide
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Biochemical Assay Reagents
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Others
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Biotin-azide (N-(3-Azidopropyl)biotinamide) is a form of biotin with a terminal azide group. Biotin-azide can be used to prepare various biotinylated conjugates via Click Chemistry . Biotin-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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- HY-153631
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- HY-B1176
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7-Dehydroestrone
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Estrogen Receptor/ERR
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Endocrinology
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Equilin (7-Dehydroestrone) is an important member of the large group of oestrogenic substances and is chemically related to menformon (oestrone). Equilin increases the growth of cortical neurons via an NMDA receptor-dependent mechanism .
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- HY-115403
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FKGK18
1 Publications Verification
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Phospholipase
Apoptosis
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Metabolic Disease
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FKGK18 is a selective group VIA calcium-independent phospholipase A2 (GVIA iPLA2) inhibitor. FKGK18 is a fluoroketone (FK)-based compound with IC50s of 50 nM and 3 μM for iPLA2β and iPLA2γ. FKGK18 can be used for the research of beta-cell apoptosis and diabetes .
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- HY-151817
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Biochemical Assay Reagents
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Others
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5-Azidomethyl-uridine is a click chemistry reagent containing an azide group. The azide function is widely used for coupling to alkyne-containing fragments via the renowned Click reaction.
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- HY-172287
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ADC Linker
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Cancer
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DBCO-PEG2-Val-Cit-PAB-MMAE is an ADC linker featuring a DBCO group, a Val-Cit dipeptide, a PAB motif, and an MMAE warhead. The DBCO group is a click chemistry handle which readily reacts with azide groups, while the Val-Cit is a protease-cleavable dipeptide which releases the MMAE warhead into cells via an elimination mechanism.
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- HY-W017425
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Phenylhydrazine acetate
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Biochemical Assay Reagents
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Others
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N'-Phenylacetohydrazide consists of a phenyl group attached to the acetylhydrazide functional group via a hydrazine bond. This compound is commonly used as a reagent in organic chemistry for the determination of carbonyl compounds such as aldehydes and ketones.
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- HY-174935
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Biochemical Assay Reagents
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Others
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DBCO-PEG1000-NHS is a dibenzocyclooctyne-conjugated polyethylene glycol derivative bearing an NHS group. DBCO-PEG-NHS forms a stable covalent linkage with the amino group of target molecules via the NHS ester at one end, while introducing a DBCO group at the other end, thus preparing for subsequent click chemical conjugation with any azide-bearing molecule or material .
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- HY-W590543
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1-Azidododecane
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Biochemical Assay Reagents
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Others
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Dodecyl azide (1-Azidododecane) is an azide group with a 12-carbon tail. Azide (N3) group can react with alkyne, BCN, DBCO via Click Chemistry.
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- HY-174935A
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Biochemical Assay Reagents
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Others
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DBCO-PEG2000-NHS is a dibenzocyclooctyne-conjugated polyethylene glycol derivative bearing an NHS group. DBCO-PEG-NHS forms a stable covalent linkage with the amino group of target molecules via the NHS ester at one end, while introducing a DBCO group at the other end, thus preparing for subsequent click chemical conjugation with any azide-bearing molecule or material .
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- HY-D1175
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- HY-W259542
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Biochemical Assay Reagents
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Others
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O-Proparagyl-N-Boc-ethanolamine is crosslinker consisting of a propargyl group and a t-Boc protected amine group. The propargyl group reacts with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry reactions. The t-Boc protected amine can be deprotected under mild acidic conditions.
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- HY-W598198
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Biochemical Assay Reagents
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Others
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Ethyl 3-azidopropanoate comprises an ethyl ester and a terminal azide group with a 2-carbon linker. The azide can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The methyl ester groups can be hydrolyzed, reduced, or substituted under different conditions.
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- HY-W007345
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4-Fluoro-2-hydroxyaniline
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Biochemical Assay Reagents
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Others
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2-Amino-5-fluorophenol is an isomer of aminofluorophenol and also a HONO generator. 2-Amino-5-fluorophenol reacts with nitrogen dioxide (NO2) via two pathways to form nitrous acid (HONO): hydrogen abstraction from the hydroxyl group and hydrogen abstraction from the amino group, with both the amino and hydroxyl groups participating in the reaction in the transition state .
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- HY-W190881
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Biochemical Assay Reagents
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Others
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N3-PEG11-CH2CH2Br is a PEG linker containing a bromine and an azide group. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The bromine (Br) is a very good leaving group for nucleophilic substitution reactions.
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- HY-W190926
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Biochemical Assay Reagents
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Others
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2,5 -Dioxo-1-pyrrolidinyl 11-azidoundecanoate is a linker containing an azide group and an NHS ester. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.
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- HY-174935C
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Biochemical Assay Reagents
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Others
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DBCO-PEG5000-NHS is a dibenzocyclooctyne-conjugated polyethylene glycol derivative bearing an NHS group. DBCO-PEG-NHS forms a stable covalent linkage with the amino group of target molecules via the NHS ester at one end, while introducing a DBCO group at the other end, thus preparing for subsequent click chemical conjugation with any azide-bearing molecule or material .
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- HY-W591975
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Biochemical Assay Reagents
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Others
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Alkyne maleimide is a bifunctional linker reagent with a terminal malimide group and a propargyl group. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The propargyl group can be linked to azide-containing biomolecules via Click Chemistry.
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- HY-W591969
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Biochemical Assay Reagents
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Others
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Benzyl (6-oxohexyl)carbamate is a linker containing an aldehyde group and a benzyl (Cbz) protecting group. The aldehyde can react with hydrazine or hydrazide to form a hydrolytic acyl hydrozone linkage. The benzyl protecting group can be removed via hydrogenolysis to form a free amine.
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- HY-W591964
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Biochemical Assay Reagents
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Others
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t-Boc-Aminooxy-pentane-azide is a linker containing an azide group and Boc-protected amino group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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- HY-W451433
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Biochemical Assay Reagents
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Others
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OTs-PEG1-NHCbz is a PEG linker containing a tosyl group and benzyl (Cbz) protecting group. The hydrophilic PEG spacer increases the water solubility of the compound in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The benzyl protecting group can be removed via hydrogenolysis to form a free amine.
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- HY-N16306
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Fluorescent Dye
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Others
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Lyso-laurdan, a derivative of Laurdan (HY-D0080), is a fluorescent probe. Lyso-Laurdan accumulates in the lysosome via a morpholine group that is entrapped in lysosome via protonation to its cationic form in the acidic compartment. Lyso-laurdan is localized to lysosomes, allowing for the study of lysosomal membranes .
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- HY-W591962
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1-Pentanol, 5-azido-
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Biochemical Assay Reagents
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Others
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5-Azidopentan-1-ol (1-Pentanol, 5-azido-) is a linker containing an azide group and a terminal hydroxyl group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.
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- HY-105549
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Antibiotic
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Infection
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Quinacillin is a compound that undergoes hydrolysis catalyzed by penicillinase. Quinacillin is irreversibly covalently bound to proteins via its β-lactam carboxyl group .
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- HY-W190786
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Biochemical Assay Reagents
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Others
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Bromoacetamido-PEG2-azide is a heterobifunctional PEG linker containing a reactive bromoacetamido and a terminal azide.The bromoacetamidogroup is a very reactive group for nucleophilic substitution. The azide group can react with alkyne, BCN, DBCO via Click Chemistry.
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- HY-W800657
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Biochemical Assay Reagents
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Others
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Azido-PEG1-hydrazide hydrochloride is a bifunctional PEG linker containing an azide group and a hydrazide group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. Hydrazine moiety reacts with an aldehyde to form semi-permanent hydrazone bonds.
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- HY-D2748
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Fluorescent Dye
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Others
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5-JOE azide is a fluorescent dye with the emission in yellow region of the spectrum. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.
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- HY-W800670
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Biochemical Assay Reagents
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Others
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Mal-amido-PEG5-alkyne is a PEG linker containing a maleimide group and an alkyne. The hydrophilic PEG spacer increases solubility in aqueous media. The alkyne group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
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- HY-W800671
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1,5-Pentane diazide
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Biochemical Assay Reagents
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Others
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1,5-Diazidopentane (1,5-Pentane diazide) is a linker with two azide groups which can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.
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- HY-174935B
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Biochemical Assay Reagents
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Others
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DBCO-PEG3400-NHS is a dibenzocyclooctyne-conjugated polyethylene glycol derivative bearing an NHS group. DBCO-PEG-NHS forms a stable covalent linkage with the amino group of target molecules via the NHS ester at one end, while introducing a DBCO group at the other end, thus preparing for subsequent click chemical conjugation with any azide-bearing molecule or material .
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- HY-174935D
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Biochemical Assay Reagents
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Others
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DBCO-PEG10000-NHS is a dibenzocyclooctyne-conjugated polyethylene glycol derivative bearing an NHS group. DBCO-PEG-NHS forms a stable covalent linkage with the amino group of target molecules via the NHS ester at one end, while introducing a DBCO group at the other end, thus preparing for subsequent click chemical conjugation with any azide-bearing molecule or material .
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- HY-W800687
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Biochemical Assay Reagents
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Others
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Tetra(3-methoxy-n-(prop-2-ynyl)propanamide) methane is a 4-branched molecule with propargyl groups that can be linked to azide-containing biomolecules via Click Chemistry.
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- HY-W190917
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Biochemical Assay Reagents
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Others
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N1, N4-Bisazidospermine bistosylate is a spermine linker containing two azide groups. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. Spermidine is a polyamine that modulates various cellular activities like cellular development and differentiation, stability of DNA, and apoptosis.
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- HY-W348348
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Biochemical Assay Reagents
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Others
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CbzNH-PEG3-CH2CH2NH2 is a PEG linker containing an amine group and a benzyl (Cbz) protecting group. The hydrophilic PEG spacer increases the water solubility of a compound in aqueous media. Amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc. The benzyl protecting group can be removed via hydrogenolysis to form a free amine.
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- HY-W403327
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Biochemical Assay Reagents
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Others
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CbzNH-PEG4-CH2COOH is a PEG linker containing an carboxylic acid (CO2H) group and a benzyl (Cbz) protecting group. The hydrophilic PEG spacer increases the water solubility of a compound in aqueous media. The terminal carboxylic acid is reactive with primary amine groups in the presence of activators (e.g. HATU) forming a stable amide bond. The benzyl protecting group can be removed via hydrogenolysis to form a free amine.
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- HY-W590545
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1-Azidooctane
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Biochemical Assay Reagents
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Others
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Octyl azide (1-Azidooctane) is a compound with an azide head and a 8-carbon tail. The azide (N3) group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.
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- HY-140895B
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Biotin-PEG10000-NH2
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Biochemical Assay Reagents
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Others
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Biotin-PEG10000-Amine (Biotin-PEG10000-NH2) is a biotin PEG polymer containing a free amine group (-NH2). The amine group is reactive with an activated NHS ester via formation of an amide bond. Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection .
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- HY-140895D
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Biotin-PEG40000-NH2
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Biochemical Assay Reagents
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Others
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Biotin-PEG40000-Amine (Biotin-PEG40000-NH2) is a biotin PEG polymer containing a free amine group (-NH2). The amine group is reactive with an activated NHS ester via formation of an amide bond. Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection .
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- HY-D2164
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Fluorescent Dye
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Others
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AF 430 alkyne is a derivative of the yellow fluorescent dye AF 430. AF430 has an excitation wavelength of 425 nm and an emission wavelength of 542 nm. AF 430 alkyne can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) via Alkyne groups and molecules containing Azide groups. To achieve specific coupling of dye labels and biomolecules .
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- HY-140895C
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Biotin-PEG20000-NH2
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Biochemical Assay Reagents
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Others
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Biotin-PEG20000-Amine (Biotin-PEG20000-NH2) is a biotin PEG polymer containing a free amine group (-NH2). The amine group is reactive with an activated NHS ester via formation of an amide bond. Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection .
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- HY-135414A
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Fluorescent Dye
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Others
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Cyanine5 NHS ester bromide is a active compound, can be used to label amino groups in peptides, proteins, and oligonucleotides. Cyanine5 NHS ester bromide is a cyanine dye, fluorescence-labeling neurotensin (8-13) via arginine residues .
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- HY-W800808
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Fluorescent Dye
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Others
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ROX azide, 5-isomer is a red-emitting rhodamine dye possessing high brightness and fluorescence quantum yield. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.
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- HY-W800717
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Biochemical Assay Reagents
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Others
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Tetra-(amido-PEG10-azide) is a branched PEG linker with four terminal azide groups. The azide groups enable PEGylation via Click Chemistry.
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- HY-W591376
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Biochemical Assay Reagents
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Others
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Azido-PEG19-azide is a click chemistry reagent with two terminal azide groups. The azide groups can react with alkyne, BCN, DBCO via Click Chemistry.
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- HY-W800716
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Biochemical Assay Reagents
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Others
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Tri(Azide-PEG10-NHCO-ethyloxyethyl)amine is a branched PEG linker with three terminal azide groups. The azide groups enable PEGylation via Click Chemistry.
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- HY-W840196
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Biochemical Assay Reagents
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Others
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Hex-5-ynehydrazide is a bifunctional linker reagent with a terminal hydrazide group and a propargyl group. The hydrazide group can react with an aldehyde to form a semi-permanent hydrozone bond. The propargyl group can be linked to azide-containing biomolecules via Click Chemistry.
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- HY-W591963
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Tos-pentane-azide
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Biochemical Assay Reagents
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Others
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5-Azidopentyl 4-methylbenzenesulfonate (Tos-pentane-azide) is a linker containing an azide group and a tosyl group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The tosyl group is a good leaving group for nucleophilic substitution reactions.
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- HY-W590574
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Biochemical Assay Reagents
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Others
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Propargyl-PEG4-Ms has an alkyne group and a mesylate group. The mesylate group is a sulfonate ester for nucleophilic substitution reactions (SN2). The alkyne group can react with azides via copper catalyzed Click Chemistry reactions. The PEG units help increase the solubility of the molecule in aqueous environments.
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- HY-W598191
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Biochemical Assay Reagents
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Others
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tert-Butyl (3-azidopropyl)carbamate is a reagent containing an azide group and Boc-protected amino group. It is reactive with alkyne, BCN, DBCO via Click Chemistry. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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- HY-W590592
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Biochemical Assay Reagents
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Others
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Azido-PEG12-azide is a monodisperse PEG linker containing two azide groups. The azide group can react with alkyne, BCN, or DBCO via Click Chemistry to yield a stable triazole linkage.
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- HY-W800681
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Biochemical Assay Reagents
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Others
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Benzyloxy carbonyl-PEG4-acid is a linker with a benzyl protecting group and a carboxylic acid. The carboxylic acid can undergo reactions with primary amines with the help of activators (EDC or HATU). The benzyl protecting group can be removed via hydrogenolysis.
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- HY-W415799
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Biochemical Assay Reagents
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Others
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(2S)-Ac4GalNAl can be used for the identification and characterization of specific surface groups of glycoproteins. The alkyne groups can react with azides via copper-catalyzed Click Chemistry. The acetyl groups on the glucose allow for easier penetration through the cell membrane.
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- HY-W598193
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Biochemical Assay Reagents
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Others
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[(5-Azidopentyl)oxy](tert-butyl)dimethylsilane is a silane compound with a terminal azide group. The trimethylsilane is commonly used for surface modifications. The terminal azide (N3) group can react with alkyne, BCN, DBCO via Click Chemistry.
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dimethylsilane](//file.medchemexpress.com/product_pic/hy-w598193.gif)
- HY-W454989
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Biochemical Assay Reagents
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Others
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Hept-6-yn-1-yl 4-methylbenzenesulfonate is a linker containing a tosyl group and a propargyl group. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage.
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- HY-172720
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Biochemical Assay Reagents
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Others
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Azide-PEG5-Ms serves as a PEG linker containing an azide that reacts with BCN, DBCO, alkyne via Click Chemistry and mesyl group that is a good leaving group for nucleophilic substitution reactions. The PEG spacer imparts water solubility.
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- HY-W598195
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Biochemical Assay Reagents
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Others
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11-Azido-1-undecanol is a compound with an azide head and a undecanol tail. The azide (N3) group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.
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- HY-W160298
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Biochemical Assay Reagents
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Others
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N-Cbz-7-Aminoheptanoic acid is a six carbon linker containing an carboxylic acid (CO2H) group and a benzyl (Cbz) protecting group. The terminal carboxylic acid is reactive with primary amine groups in the presence of activators (e.g. EDC, or HATU) forming a stable amide bond. The benzyl protecting group can be removed via hydrogenolysis to form a free amine.
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- HY-W800688
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Biochemical Assay Reagents
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Others
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Acid-PEG5-Amide-Tri(3-methoxypropanamide-PEG4-Azide) Methane is a branched PEG linker with a terminal carboxylic acid group and three terminal azides. The azide groups enables PEGylation via Click Chemistry.
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- HY-W590575
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Biochemical Assay Reagents
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Others
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Azido-PEG3-flouride is a PEG linker containing a fluorine atom and an azide group. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.
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- HY-W598194
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Biochemical Assay Reagents
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Others
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1-((4-Azidobutoxy)methyl)-4-methoxybenzene is a compound with a methyl phenol group and a butyl tail ending in a terminal azide. The azide (N3) group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.
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- HY-134107
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Biochemical Assay Reagents
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Others
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Azido-erythro-sphingosines is an intermidate for synthesis of lipid molecules with two hydroxyl groups and a terminal azide group. Azide (N3) group can react with alkyne, BCN, DBCO via Click Chemistry. The hydroxyl groups enable further derivatization or replacement with other reactive functional groups. Azido-erythro-sphingosine is a derivative of Sphingosine, which is a selective inhibitor of protein kinase C activity and phorbol dibutyrate binding in vitro in human platelets.
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- HY-W598192
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4-Azidobutyl benzoate
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Biochemical Assay Reagents
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Others
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1-Butanol, 4-azido-, 1-benzoate (4-Azidobutyl benzoate) is a compound with an ethyl benzoate head and a terminal azide group. The ethyl benzoate protected carboxyl group can be deprotected under acidic conditions. Azide (N3) group can react with alkyne, BCN, DBCO via Click Chemistry.
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- HY-W197430
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Biochemical Assay Reagents
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Others
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Ethyl 6-azidohexanoate comprises an ethyl ester and a terminal azide group with a 5-carbon linker. The azide can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The methyl ester groups can be hydrolyzed, reduced, or substituted under different conditions.
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- HY-W598199
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Biochemical Assay Reagents
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Others
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Ethyl 4-azidobutyrate comprises an ethyl ester and a terminal azide group with a 3-carbon linker. The azide can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The methyl ester groups can be hydrolyzed, reduced, or substituted under different conditions.
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- HY-W451460
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Biochemical Assay Reagents
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Others
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2,5-Dioxopyrrolidin-1-yl 2-(prop-2-yn-1-yloxy)acetate is a Click Chemistry reagent with a propargyl group and an NHS ester group. The propargyl group can react with biomolecules containing azide group via copper catalyzed Click Chemistry reaction. The NHS ester is an amine reactive group which can be used for derivatizing peptides, antibodies, amine coated surfaces, etc.
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- HY-W800664
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Biochemical Assay Reagents
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Others
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5-(Azido-PEG4)-pent-2-yn-1-Ol is a PEG linker containing an azide group and a terminal hydroxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.
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- HY-400849
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Drug Intermediate
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Others
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Losartan impurity 14 (Compound I) is a Losartan (HY-17512) impurity containing an azido group. Losartan impurity 14 can be converted into an amino compound via organophosphorus reagents .
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- HY-W591360
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Biochemical Assay Reagents
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Others
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Iodoacetamido-PEG6-azide is an aqueous soluble PEG linker containing an azide and a terminal Iodoacetamido group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The Iodoacetamido moiety is commonly used to bind covalently with the thiol group of cysteine so the protein cannot form disulfide bonds.
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-
- HY-W800807
-
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Fluorescent Dye
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Others
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R6G azide, 5-isomer is a xanthene dye with a terminal azide. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.
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- HY-W800706
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Biochemical Assay Reagents
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Others
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Azidobutanamide-tri-(carboxyethoxymethyl)-methane is a aqueous soluble PEG linker with an azide group with three terminal carboxylic acids. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
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-
- HY-200288B
-
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Biochemical Assay Reagents
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Others
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DMG-PEG3400-COOH is a conjugate composed of DMG, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DMG-PEG3400-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.
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- HY-W1052117A
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Biochemical Assay Reagents
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Others
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DMPE-PEG3400-COOH is a conjugate composed of DMPE, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DMPE-PEG3400-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.
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-
- HY-W1052873C
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Biochemical Assay Reagents
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Others
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DPPE-PEG1000-COOH is a conjugate composed of DPPE, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DPPE-PEG1000-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.
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-
- HY-W1052117
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Biochemical Assay Reagents
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Others
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DMPE-PEG2000-COOH is a conjugate composed of DMPE, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DMPE-PEG2000-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.
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-
- HY-183173B
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Biochemical Assay Reagents
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Others
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DSG-PEG3400-COOH is a conjugate composed of DSG, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DSG-PEG3400-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.
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-
- HY-183173
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Biochemical Assay Reagents
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Others
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DSG-PEG1000-COOH is a conjugate composed of DSG, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DSG-PEG1000-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.
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-
- HY-W1052873D
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Biochemical Assay Reagents
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Others
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DPPE-PEG10000-COOH is a conjugate composed of DPPE, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DPPE-PEG10000-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.
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-
- HY-200288
-
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Biochemical Assay Reagents
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Others
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|
DMG-PEG2000-COOH is a conjugate composed of DMG, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DMG-PEG2000-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.
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-
- HY-183173A
-
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Biochemical Assay Reagents
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Others
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|
DSG-PEG2000-COOH is a conjugate composed of DSG, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DSG-PEG2000-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.
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-
- HY-200288A
-
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Biochemical Assay Reagents
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Others
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|
DMG-PEG1000-COOH is a conjugate composed of DMG, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DMG-PEG1000-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.
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-
- HY-W1052873
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Biochemical Assay Reagents
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Others
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DPPE-PEG2000-COOH is a conjugate composed of DPPE, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DPPE-PEG2000-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.
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-
- HY-W1052117D
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Biochemical Assay Reagents
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Others
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DMPE-PEG1000-COOH is a conjugate composed of DMPE, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DMPE-PEG1000-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.
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-
- HY-183173D
-
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Biochemical Assay Reagents
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Others
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DSG-PEG10000-COOH is a conjugate composed of DSG, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DSG-PEG10000-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.
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-
- HY-200288D
-
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Biochemical Assay Reagents
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Others
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DMG-PEG10000-COOH is a conjugate composed of DMG, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DMG-PEG10000-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.
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-
- HY-W1052873B
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Biochemical Assay Reagents
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Others
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DPPE-PEG5000-COOH is a conjugate composed of DPPE, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DPPE-PEG5000-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.
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-
- HY-W1052873A
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Biochemical Assay Reagents
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Others
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DPPE-PEG3400-COOH is a conjugate composed of DPPE, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DPPE-PEG3400-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.
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-
- HY-W1052117C
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Biochemical Assay Reagents
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Others
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DMPE-PEG1000-COOH is a conjugate composed of DMPE, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DMPE-PEG1000-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.
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-
- HY-183173C
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Biochemical Assay Reagents
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Others
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DSG-PEG5000-COOH is a conjugate composed of DSG, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DSG-PEG5000-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.
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-
- HY-200288C
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Biochemical Assay Reagents
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Others
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DMG-PEG5000-COOH is a conjugate composed of DMG, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DMG-PEG5000-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.
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-
- HY-W1052117B
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Biochemical Assay Reagents
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Others
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|
DMPE-PEG5000-COOH is a conjugate composed of DMPE, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DMPE-PEG5000-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.
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-
- HY-W590544
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Biochemical Assay Reagents
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Others
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1-Azidodecane is a compound with an azide head and a 10-carbon tail. The azide (N3) group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.
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- HY-119015
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MCHR1 (GPR24)
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Metabolic Disease
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|
MCHR1 antagonist 6 is a melanin-concentrating hormone receptor 1 (MCHR1) antagonist. MCHR1 antagonist 6 interacts with receptor residue D123 via its central basic group, and forms hydrogen bonds with receptor residue Q127 via its 2-amino-quinoline portion. MCHR1 antagonist 6 can be used for the research of obesity .
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- HY-W837135
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Ligands for E3 Ligase
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Cancer
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5-Hydrazinyl thalidomide hydrochloride is a Thalidomide analogue featuring a hydrazine. PROTAC linkers are made to recruit E3 ligase for the ubiquitinylation of target proteins. The hydrazine may be used for further derivatization via reactions with various carbonyl groups.
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- HY-140895A
-
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Biotin-PEG5000-NH2
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Biochemical Assay Reagents
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Others
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Biotin-PEG5000-Amine (Biotin-PEG5000-NH2) is a biotin PEG polymer containing a free amine group (-NH2). The amine group is reactive with an activated NHS ester via formation of an amide bond. Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection .
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-
- HY-W800842
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Biochemical Assay Reagents
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Others
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1-Ethylnonyl 8-bromooctanoate is a lipid featuring a bromide along an octanoate chain linking to a C11 chain. 1-Ethylnonyl 8-bromooctanoate can be derivatized via substitution at the bromide leaving group.
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- HY-W451415
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Biochemical Assay Reagents
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Others
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NHS-PEG-NHS is a derivative of activated polyethylene glycol (PEG) that can modify functional groups on protein surfaces via covalent binding. NHS-PEG-NHS serves as a bioconjugation modification reagent for modifying proteins, enzymes, peptides and antibodies .
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- HY-P2801A
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Phosphatase
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Metabolic Disease
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Glucose-6-Phosphatase, Rabbit (EC 3.1.3.9) is an enzyme that hydrolyzes glucose-6-phosphate, resulting in the creation of a phosphate group and free glucose. Glucose is then exported from the cell via glucose transporter membrane proteins.
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-
- HY-183168B
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Biochemical Assay Reagents
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Others
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C18-PEG5000-COOH is a conjugate composed of an octadecyl group (C18 aliphatic chain), a PEG chain, and a carboxyl group (-COOH). C18-PEG5000-COOH combines the membrane compatibility of lipids with the carboxyl group, which can form amide bonds with primary amines via EDC/NHS activation, making it suitable for research in biomaterial construction and drug delivery.
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-
- HY-183168A
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Biochemical Assay Reagents
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Others
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|
C18-PEG3400-COOH is a conjugate composed of an octadecyl group (C18 aliphatic chain), a PEG chain, and a carboxyl group (-COOH). C18-PEG3400-COOH combines the membrane compatibility of lipids with the carboxyl group, which can form amide bonds with primary amines via EDC/NHS activation, making it suitable for research in biomaterial construction and drug delivery.
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-
- HY-183168
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Biochemical Assay Reagents
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Others
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|
C18-PEG2000-COOH is a conjugate composed of an octadecyl group (C18 aliphatic chain), a PEG chain, and a carboxyl group (-COOH). C18-PEG2000-COOH combines the membrane compatibility of lipids with the carboxyl group, which can form amide bonds with primary amines via EDC/NHS activation, making it suitable for research in biomaterial construction and drug delivery.
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-
- HY-W575291
-
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N-Boc-oct-7-yn-1-amine
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Biochemical Assay Reagents
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Others
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|
tert-Butyl oct-7-yn-1-ylcarbamate (N-Boc-oct-7-yn-1-amine) is crosslinker consisting of a propargyl group and a t-Boc protected amine group. The propargyl group reacts with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry reactions. The t-Boc protected amine can be deprotected under mild acidic conditions.
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- HY-133022
-
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(E)-2-Undecenoic acid; (E)-Undec-2-enoic acid
|
Drug Isomer
|
Metabolic Disease
|
|
trans-2-Undecenoic acid ((E)-2-Undecenoic acid) is an α,β-unsaturated carboxylic acid and is characterized by acid dimers. The corresponding dimers are connected via intermolecular hydrogen bonds of the carboxylic groups C=O···H-O .
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-
- HY-116018
-
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Phospholipase
|
Neurological Disease
Inflammation/Immunology
Cancer
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|
FKGK11 is a potent and selective inhibitor of GVIA iPLA2 (Group VIA calcium-independent phospholipase A2). FKGK11 can be used for the research of ovarian cancer and neurological disorders such as peripheral nerve injury and multiple sclerosis .
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-
- HY-D2151
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Fluorescent Dye
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Others
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|
AF 430 hydrazide is a derivative of the yellow fluorescent dye AF 430. AF430 has an excitation wavelength of 425 nm and an emission wavelength of 542 nm. AF 430 hydrazide can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) via the Azide group and molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups. To achieve specific coupling of dye labels and biomolecules .
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-
- HY-148835
-
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Fluorescent Dye
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Others
|
|
AzGGK is an unnatural amino acid. AzGGK is site-specifically incorporated into proteins via genetic-code expansion. AzGGK can be used as site-specific probe for ubiquitylation and SUMOylation . AzGGK is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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-
- HY-D2156
-
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Fluorescent Dye
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Others
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|
AF 430 azide is a derivative of the yellow fluorescent dye AF 430. AF430 has an excitation wavelength of 425 nm and an emission wavelength of 542 nm. AF 430 azide can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) via the azide group and molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. To achieve specific coupling of dye labels and biomolecules .
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-
- HY-D1320
-
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Fluorescent Dye
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Others
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|
Cyanine5 azide chloride is a potent fluorescent dye. Cyanine5 azide chloride can be reacted with terminal alkynes via a copper-catalyzed click reaction (CuAAC). (λex=646 nm, λem=662 nm) . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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-
- HY-132975
-
|
|
Bacterial
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Others
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|
PrDiAzK is a bifunctional amino acid. PrDiAzK can be site-selectively incorporated into proteins in both bacterial and mammalian cell culture. PrDiAzK can be used for proteome-wide incorporation via stochastic orthogonal recoding of translation (SORT) . PrDiAzK is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
- HY-D2167
-
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Fluorescent Dye
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Others
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|
AF 568 alkyne is a derivative of the orange fluorescent dye AF 568. AF 568 has an absorption wavelength of 590-720 nm (FRET) and an emission wavelength of 515-720 nm. AF 568 alkyne can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) via the Alkyne group and molecules containing Azide groups. To achieve specific coupling of dye labels and biomolecules .
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-
- HY-151742
-
|
|
ADC Linker
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Others
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|
Norbornene-methyl-NHS is a norbornene-based antibody-drug conjugate linker (ADC Linker) bearing methyl and NHS ester functional groups, which can be used for specific antibody conjugation. Norbornene-methyl-NHS is also a click chemistry reagent containing a TCO group, acting as a dienophile for conjugation via the Diels-Alder reaction, namely the copper-free click reaction with tetrazine .
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-
- HY-157181
-
|
|
Biochemical Assay Reagents
|
Inflammation/Immunology
|
|
Hal-HS, a happen, fully protects and highlights the main functional groups of the molecule, thereby completely exposing it to the immune system. Hal-HS can be covalently attached to BSA via the active ester method to obtain hapten–protein conjugates (Hal-BSA) as immunogen .
|
-
- HY-100216
-
SPDP
5 Publications Verification
SPDP Crosslinker; Py-ds-Prp-OSu
|
ADC Linker
|
Cancer
|
|
SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs) .
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-
- HY-W1048860B
-
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Biochemical Assay Reagents
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Others
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|
4-Arm PEG10000-alkyne is a multi-arm PEG derivative with alkynyl groups at each end of four arms attached to a pentaerythritol core. PEG alkyne can be used for PEGylation via copper-catalyzed click chemistry with azides .
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-
- HY-W1048860D
-
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Biochemical Assay Reagents
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Others
|
|
4-Arm PEG40000-alkyne is a multi-arm PEG derivative with alkynyl groups at each end of four arms attached to a pentaerythritol core. PEG alkyne can be used for PEGylation via copper-catalyzed click chemistry with azides .
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-
- HY-W1048860A
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Biochemical Assay Reagents
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Others
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|
4-Arm PEG5000-alkyne is a multi-arm PEG derivative with alkynyl groups at each end of four arms attached to a pentaerythritol core. PEG alkyne can be used for PEGylation via copper-catalyzed click chemistry with azides .
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-
- HY-B1176S
-
|
7-Dehydroestrone-d4
|
Isotope-Labeled Compounds
Estrogen Receptor/ERR
|
Endocrinology
|
|
Equilin-d4 is the deuterium labeled Equilin. Equilin (7-Dehydroestrone) is an important member of the large group of oestrogenic substances and is chemically related to menformon (oestrone). Equilin increases the growth of cortical neurons via an NMDA receptor-dependent mechanism .
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-
- HY-W1048860C
-
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Biochemical Assay Reagents
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Others
|
|
4-Arm PEG20000-alkyne is a multi-arm PEG derivative with alkynyl groups at each end of four arms attached to a pentaerythritol core. PEG alkyne can be used for PEGylation via copper-catalyzed click chemistry with azides .
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-
- HY-151730
-
|
|
ADC Linker
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Others
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|
(Me)Tz-butanoic acid is a click chemistry reagent containing an azide. (Me)Tz-butanoic acid is tetrazine linker for conjugation via Diels-Alder-reaction, i.e. copper-free Click reaction with dienophiles . (Me)Tz-butanoic acid is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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-
- HY-133492
-
|
|
Drug-Linker Conjugates for ADC
|
Cancer
|
|
DBCO-PEG4-MMAF is a agent-linker conjugate for ADC with potent antitumor activity by using the tubulin polymerization inhibitor, MMAF, linked via the linker DBCO-PEG4. DBCO-PEG4-MMAF is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
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-
- HY-W440896
-
|
|
Liposome
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Others
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|
DSPE-PEG2000-SH is an amphiphilic thiol-functionalized DSPE-PEG molecule. DSPE-PEG2000-SH inserts into extracellular vesicle (EV) bilayer membranes via hydrophobic interactions, displaying surface thiol groups to form EV-SH crosslinkers.DSPE-PEG2000-SH enables crosslinking of EV-SH with 8-arm PEG-norbornene via thiol-ene photochemistry to construct hydrogels, with hydrogel mechanical properties tunable via PEG segment molecular weight variation.DSPE-PEG2000-SH can be used to encapsulate agents for drug delivery system, such as mRNA vaccine .
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-
- HY-172270D
-
|
|
Liposome
|
Cancer
|
|
DSPE-PEG1000-PTP is synthesised by conjugating the amino group of plectin-1 peptide (PTP) with DSPE-PEG-NHS ester via amide bonds. DSPE-PEG1000-PTP can be used to construct drug delivery vectors .
|
-
- HY-172270C
-
|
|
Liposome
|
Cancer
|
|
DSPE-PEG1000-PTP is synthesised by conjugating the amino group of plectin-1 peptide (PTP) with DSPE-PEG-NHS ester via amide bonds. DSPE-PEG1000-PTP can be used to construct drug delivery vectors .
|
-
- HY-172270
-
|
|
Liposome
|
Cancer
|
|
DSPE-PEG1000-PTP is synthesised by conjugating the amino group of plectin-1 peptide (PTP) with DSPE-PEG-NHS ester via amide bonds. DSPE-PEG1000-PTP can be used to construct drug delivery vectors .
|
-
- HY-172270A
-
|
|
Liposome
|
Cancer
|
|
DSPE-PEG1000-PTP is synthesised by conjugating the amino group of plectin-1 peptide (PTP) with DSPE-PEG-NHS ester via amide bonds. DSPE-PEG1000-PTP can be used to construct drug delivery vectors .
|
-
- HY-D2168
-
|
|
Fluorescent Dye
|
Others
|
|
AF 568 azide is an azide derivative of the orange fluorescent dye AF 568. AF 568 has an absorption wavelength of 590-720 nm (FRET) and an emission wavelength of 515-720 nm. AF 568 alkyne can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) via the Azide group and molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups. To achieve specific coupling of dye labels and biomolecules .
|
-
- HY-148835A
-
|
|
Fluorescent Dye
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Others
|
|
AzGGK TFA is an unnatural amino acid. AzGGK TFA is site-specifically incorporated into proteins via genetic-code expansion. AzGGK TFA can be used as a site-specific probe for ubiquitylation and SUMOylation. AzGGK TFA is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups .
|
-
- HY-W800709
-
|
|
Biochemical Assay Reagents
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Others
|
|
N-(acid-PEG10)-N-bis(PEG10-azide) is a very popular PEG reagent containing a terminal carboxylic acid and two azide groups. The hydrophilic PEG spacer increases solubility in aqueous media. The azide groups can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
|
-
- HY-130296
-
|
PROTAC CDK6 ligand 1
|
Ligands for Target Protein for PROTAC
|
Cancer
|
|
Palbociclib-propargyl is a ligand for target protein CDK6 for PROTAC, and binds to CRBN ligand via a PEG linker to make a PROTAC CP-10. CP-10 shows a DC50 of 2.1 nM for CDK6 . Palbociclib-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-131642
-
|
H-Gla-OH
|
mGluR
|
Neurological Disease
|
|
L-γ-Carboxyglutamic acid (H-Gla-OH) is a mGluR2 antagonist with an IC50 of 102 μM. L-γ-Carboxyglutamic acid binds to the mGluR2 receptor site via the overlapping extended amino acid conformation of its amino and carboxyl groups with glutamic acid, and its additional acidic group locates in a restricted region, thereby blocking the full activation of the receptor. L-γ-Carboxyglutamic acid can be used for the research of neurological disorders .
|
-
- HY-133433
-
|
|
Drug-Linker Conjugates for ADC
|
Cancer
|
|
DBCO-PEG4-VA-PBD is a agent-linker conjugate for ADC by using the antitumor antibiotic, Pyrrolobenzodiazepine (PBD), linked via DBCO-PEG4-VA . DBCO-PEG4-VA-PBD is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
|
-
- HY-N0327
-
|
|
Apoptosis
Xanthine Oxidase
|
Metabolic Disease
|
|
Lobetyolin, a bioactive compound, is derived from Codonopsis pilosula. Lobetyolin has anti-inflammatory, anti-oxidative and xanthine oxidase inhibiting activities. Lobetyolin also induces the apoptosis via the inhibition of ASCT2-mediated glutamine metabolism . Lobetyolin is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-W012206
-
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SULT
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Neurological Disease
Cancer
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(Rac)-Metanephrine hydrochloride is a metabolite of epinephrine and a substrate of the sulfotransferase SULT1A3. (Rac)-Metanephrine hydrochloride undergoes sulfonation at its p-hydroxyl group via a reaction catalyzed by SULT1A3. (Rac)-Metanephrine hydrochloride is an isomer of Metanephrine (HY-113299) hydrochloride, and it is applicable to the research of pheochromocytoma .
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- HY-105129
-
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Biochemical Assay Reagents
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Cancer
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Pimonidazole is a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in tumor . Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after reduction of its nitro group, it can be used for qualitative and quantitative assessment of tumor hypoxia .
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- HY-404548
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Biochemical Assay Reagents
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Others
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Sulfo-TAG TFP ester disodium is a tetrafluorophenyl (TFP) ester that can be coupled to proteins via primary amine groups. Sulfo-TAG TFP ester disodium is more hydrophobic than NHS esters and exhibits higher hydrolytic stability in aqueous solutions. Sulfo-TAG TFP ester disodium can be used for antibody labeling.
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- HY-W015302
-
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Orthanilic acid; 2-Aminobenzenesulphonic acid
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Drug Intermediate
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Others
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2-Aminobenzenesulfonic acid is an anilinesulfonic acid and also the ortho-isomer of aminobenzenesulfonic acid. 2-Aminobenzenesulfonic acid can be used in the synthesis of other active compounds. 2-Aminobenzenesulfonic acid can coordinate via its -NH2 and -SO3 groups to form polymeric copper (II) complexes .
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- HY-105129A
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Biochemical Assay Reagents
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Cancer
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Pimonidazole is a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in tumor . Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after reduction of its nitro group, it can be used for qualitative and quantitative assessment of tumor hypoxia .
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- HY-B1176R
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7-Dehydroestrone (Standard)
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Reference Standards
Estrogen Receptor/ERR
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Endocrinology
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Equilin (Standard) is the analytical standard of Equilin. This product is intended for research and analytical applications. Equilin (7-Dehydroestrone) is an important member of the large group of oestrogenic substances and is chemically related to menformon (oestrone). Equilin increases the growth of cortical neurons via an NMDA receptor-dependent mechanism .
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- HY-W068119A
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2-Maleimidoethylamine hydrochloride
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Biochemical Assay Reagents
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Cancer
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N-(2-Aminoethyl)maleimide (2-Maleimidoethylamine) hydrochloride is a selective covalent binding agent for thiol groups (RSGs), covalently binding to thiols via an irreversible thioether bond to prepare MMP-2-sensitive nanosystems. Under near-neutral conditions, the maleimide group in N-(2-Aminoethyl)maleimide hydrochloride binds to thiol groups via a nucleophilic addition reaction, and can be used to modify polymers or biological interfaces, enhancing mucosal adhesion and regulating the surface charge of biological interfaces. N-(2-Aminoethyl)maleimide hydrochloride can optimize the adhesion performance of drug delivery carriers and cell interactions with biological interfaces, and is applied in transmucosal drug delivery systems (such as drug carriers for oral and bladder sites) and biomaterial surface engineering research, providing support for tissue implantation, regeneration, and related drug delivery .
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- HY-W1052510
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Biochemical Assay Reagents
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Others
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N3-PEG2-CH2CO2-NHS is a PEG derivative containing an azide group and an NHS ester. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.
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- HY-76222
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Drug Intermediate
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Others
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Isatoic anhydride is a single-adduct forming reagent and a monofunctional SHAPE reagent. Isatoic anhydride reacts with the 2'-hydroxyl group of RNA nucleotides via a single reactive group to form a single adduct, without forming cross-links between nucleotides. In SHAPE-JuMP experiments, Isatoic anhydride serves as a control reagent for single-adduct formation, which is used to distinguish true cross-links from single-adduct formation .
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- HY-13728
-
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ZD 9331; BGC9331
|
Thymidylate Synthase
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Cancer
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|
Plevitrexed (ZD 9331; BGC 9331) is an orally active and potent thymidylate synthase (TS) inhibitor with a Ki of 0.44 nM. Plevitrexed is taken up via the α-folate receptor as well as the reduced folate carrier. Plevitrexed is used for gastric cancer in clinical . Plevitrexed is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-181228
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Biochemical Assay Reagents
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Others
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DBCO-PEG10-Biotin is an azadibenzocyclooctyne-biotin derivative containing a biotin group and 10 PEGs. DBCO-PEG10-Biotin is a versatile biotinylation reagent used for the introduction of a biotin moiety to azide-labeled biomolecules via copper-free strain-promoted alkyne-azide click chemistry (SPAAC) reaction. DBCO-PEG10-Biotin is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups .
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- HY-130809
-
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Biochemical Assay Reagents
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Cancer
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DBCO-PEG4-Biotin is an azadibenzocyclooctyne-biotin derivative containing a biotin group and 4 PEGs. DBCO-PEG4-Biotin is a versatile biotinylation reagent used for the introduction of a biotin moiety to azide-labeled biomolecules via copper-free strain-promoted alkyne-azide click chemistry (SPAAC) reaction . DBCO-PEG4-Biotin is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
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- HY-183133B
-
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Biochemical Assay Reagents
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Others
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C16-PEG5000-COOH is a conjugate composed of a hexadecyl (C16 aliphatic chain), a PEG chain, and a carboxyl group (-COOH). C16-PEG5000-COOH combines the membrane compatibility of lipids with the carboxyl group, which can form amide bonds with primary amines via EDC/NHS activation, making it suitable for research in biomaterial construction and drug delivery.
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-
- HY-137397
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8-OH-EFV
|
Apoptosis
JNK
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Cancer
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|
8-Hydroxyefavirenz (8-OH-EFV) is a primary metabolite of (HY-10572). 8-Hydroxyefavirenz induces apoptosis via a JNK- and BimEL-dependent mechanism in primary human hepatocytes. 8-Hydroxyefavirenz can be used in research of cancer . 8-Hydroxyefavirenz is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-183133
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Biochemical Assay Reagents
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Others
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|
C16-PEG2000-COOH is a conjugate composed of a hexadecyl (C16 aliphatic chain), a PEG chain, and a carboxyl group (-COOH). C16-PEG2000-COOH combines the membrane compatibility of lipids with the carboxyl group, which can form amide bonds with primary amines via EDC/NHS activation, making it suitable for research in biomaterial construction and drug delivery.
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- HY-183133A
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Biochemical Assay Reagents
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Others
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C16-PEG3400-COOH is a conjugate composed of a hexadecyl (C16 aliphatic chain), a PEG chain, and a carboxyl group (-COOH). C16-PEG3400-COOH combines the membrane compatibility of lipids with the carboxyl group, which can form amide bonds with primary amines via EDC/NHS activation, making it suitable for research in biomaterial construction and drug delivery.
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-
- HY-W190951
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Biochemical Assay Reagents
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Others
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3-((2-(2,2,2-Trifluoroacetamido)ethyl)disulfanyl)propanoic acid is a cleavable linker containing a carboxylic acid. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The disulfide bond can be cleaved via reduction reactions.
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- HY-151859
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Biochemical Assay Reagents
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Others
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N3-Gly-Gly-Gly-OH is a click chemistry reagent containing an azide group. N3-Gly-Gly-OH undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing an alkyne group. N3-Gly-Gly-OH also undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups. N3-Gly-Gly-Gly-OH can be used to construct peptide-like ADC linkers via click chemistry .
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- HY-168940B
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Drug Intermediate
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Cancer
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NH2-PEG2000-COOH is a heterofunctional polyethylene glycol with one amino terminal group and one carboxyl terminal group. NH2-PEG2000-COOH reacts with N-succinimidyl-6-maleimidohexanoate to introduce a maleimide terminal group, followed by conjugation with thiolated RGD peptide via a thiol-maleimide coupling reaction to synthesize RGD-PEG-COOH. NH2-PEG2000-COOH can be used in cancer research .
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- HY-B1176S1
-
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7-Dehydroestrone-d2
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Isotope-Labeled Compounds
Estrogen Receptor/ERR
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Endocrinology
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|
Equilin-d2 (7-Dehydroestrone-d2) is deuterium labeled Equilin. Equilin (7-Dehydroestrone) is an important member of the large group of oestrogenic substances and is chemically related to menformon (oestrone). Equilin increases the growth of cortical neurons via an NMDA receptor-dependent mechanism .
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- HY-151691
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ADC Linker
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Others
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Trisulfo-Cy3 Methyltetrazine is a click chemistry reagent containing an methyltetrazine group. Methyltetrazine-activated Cy3 probe reacts with TCO-containing compounds via an Inverse-Electron-Demand Diels-Alder reaction to form a stable covalent bond and does not require Cu-catalyst or elevated temperatures .
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- HY-134723
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Drug-Linker Conjugates for ADC
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Cancer
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DBCO-PEG4-GGFG-Dxd is a agent-linker conjugate for ADC with potent antitumor activity by using Dxd (a DNA topoisomerase I inhibitor), linked via the cleavable ADC linker DBCO-PEG4-GGFG . DBCO-PEG4-GGFG-Dxd is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
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- HY-154992
-
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F2PhEtyCbl
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Others
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Others
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2,4-Difluorophenylethynylcobalamin is a potential B12 antivitamin via binding to human B12 -processing enzyme CblC with high affinity (KD=130 nm). 2,4-Difluorophenylethynylcobalamin withstood tailoring by CblC, and stabilizes the ternary complex with the cosubstrate glutathione (GSH) . 2,4-Difluorophenylethynylcobalamin is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-107442
-
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Epigenetic Reader Domain
Ligands for Target Protein for PROTAC
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Cancer
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|
PROTAC BRD4-binding moiety 1 is a ligand for BRD4. PROTAC BRD4-binding moiety 1 binds to cereblon ligand via a linker to form PROTAC to degrade BRD4 (HY-133136) . PROTAC BRD4-binding moiety 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-44103
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PROTAC BRD4-binding moiety 4
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Ligands for Target Protein for PROTAC
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Cancer
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|
Desmethyl-QCA276 (PROTAC BRD4-binding moiety 4), the QCA276-based moiety, binds to cereblon ligand via a linker to form PROTAC to degrade BET. QCA276 is a BET inhibitor with an IC50 of 10 nM, and with a Ki of 2.3 nM . Desmethyl-QCA276 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-W075836
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Biochemical Assay Reagents
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Others
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Ferrocenylmethyltrimethylammonium (iodide) is an organometallic salt consisting of a ferrocenyl group attached to a quaternary ammonium cation via a methylene bridge. Ferrocenylmethyltrimethylammonium (iodide) has been used as a catalyst and reagent in various organic reactions, including oxidation, reduction, and CH bond activation. In addition, it is also used as a precursor for the synthesis of other organometallic compounds and as a potential material for electrochemical applications.
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- HY-E71085
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Biochemical Assay Reagents
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Others
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(R)-2-Hydroxy-4-methylpentanoate CoA-transferase (EC 2.8.3.24) , characterized from the bacterium Peptoclostridium difficile, participates in an L-leucine fermentation pathway. The reaction proceeds via formation of a covalent anhydride intermediate between a conserved aspartate residue and the acyl group of the CoA thioester substrate.
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- HY-133513
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(±)-H3L28
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Drug Derivative
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Cancer
|
|
(±)-H3RESCA-TFP ((±)-H3L28) is a tetrafluorophenyl ester derivative of restrained complexing agent (RESCA). (±)-H3RESCA-TFP can be used to conjugate the chelator with a biomolecule via amine coupling (e.g., N terminus and/or the ε-amino groups of lysine) .
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- HY-151687
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ADC Linker
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Others
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Fmoc-L-Tyr(2-azidoethyl)-OH is a click chemistry reagent containing an azide group. Fmoc-L-Tyr(2-azidoethyl)-OH is unnatural Fmoc-protected Tyrosine derivative bears an azidoethyl substitution as reactive handle e.g. for biorthogonal conjugations, via a Cu(I)-catalyzed 1,3-dipolar Click cycloaddition with alkynes. And azido-UAAs can be employed as IR reporters . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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- HY-P0132A
-
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NO Synthase
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Cancer
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|
YIGSR-Lys(N3) is a peptide that can inhibit the tumour growth and metastasis of leukaemic cells. YIGSR blocks the cellular binding to laminin I via a 67-kDa laminin-binding protein, and inhibits shear-induced increase in eNOS expression of laminin cells . YIGSR-Lys(N3) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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- HY-151859A
-
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Biochemical Assay Reagents
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Others
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|
N3-Gly-Gly-OH DCHA is a click chemistry reagent containing an azide group. N3-Gly-Gly-OH DCHA undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing an alkyne group. N3-Gly-Gly-OH DCHA also undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups. N3-Gly-Gly-OH DCHA can be used to construct peptide-like ADC linkers via click chemistry .
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- HY-151782
-
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ADC Linker
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Others
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|
The azide function is widely used for coupling to alkyne-containing fragments via the renowned Click reaction. Polyglycine fragments containing up to 7 glycines are reported to bind to surfaces and have potential application in nanotechnology constructs: constructs of Gly7-NHCH2-fragment containing peptides bind on mica surface in aqueous solution . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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-
- HY-W457953
-
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Biochemical Assay Reagents
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Others
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|
tert-Butyl N-(4-azidobutyl)carbamate is N-Boc protected crosslinker. tert-Butyl N-(4-azidobutyl)carbamate can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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-
- HY-177344
-
|
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Biochemical Assay Reagents
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Cancer
|
|
IAJD-97 is a single-component ionizable amphiphilic Janus dendrimer carrier targeting mRNA delivery, which self-assembles into dendrimersomes (DNPs) via pH-responsive mechanisms to efficiently encapsulate and protect mRNA, while facilitating cellular uptake and endosomal escape through ionizable amine groups. IAJD-97 is promising for research of cancers .
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-
- HY-105129AS
-
|
|
Isotope-Labeled Compounds
|
Cancer
|
|
Pimonidazole-d10 is the deuterium labeled Pimonidazole. Pimonidazole is a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in tumor . Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after reduction of its nitro group, it can be used for qualitative and quantitative assessment of tumor hypoxia .
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-
- HY-146231A
-
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|
MAP4K
PROTACs
|
Inflammation/Immunology
Cancer
|
|
SS47 TFA, a PROTAC-based HPK1 degrader, exerts proteasome-mediated HPK1 degradation. The degradation of HPK1 via SS47 also significantly enhances the in vivo antitumor efficacy of BCMA CAR-T cell research. HPK1, an immunosuppressive regulatory kinase, is a promising target for cancer immunotherapies . SS47 (TFA) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
- HY-W800775
-
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Fluorescent Dye
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Others
|
|
BP Fluor 647 Alkyne is a bright green-fluorescent dye optimal for use with the 633, 650 nm Argon laser. The alkyne group can react with azides via copper catalyzed Click Chemistry reactions. The dye is water soluble and pH-insensitive from pH 4 to pH 10. The dye has 4 sulfonate groups which make it highly water soluble and cause less aggregation in the aqueous solution. BP Fluor 647 Alkyne is used for protein and antibody labeling, or nucleic acid applications with high labeling density.
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- HY-175424
-
|
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Others
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Others
|
|
N3-CMC is a click chemistry reagent. N3-CMC containing an azide group can undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups. N3-CMC can also undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. N3-CMC reacts specifically with the pseudouridine (Ψ)-containing RNA, and biotin is subsequently conjugated to the N3-CMC-Ψ RNA via click chemistry, quantitatively analyzing the dynamic changes of Ψ .
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- HY-W1048558A
-
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mPEG2000-COOH
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Biochemical Assay Reagents
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Others
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|
mPEG2000-CM (mPEG2000-COOH) is a carboxyl-terminated monomethoxy polyethylene glycol. mPEG2000-CM bears a reactive carboxyl group (-COOH) at its structural terminal site, which can form stable amide bonds with amino groups and ester bonds with hydroxyl groups. mPEG2000-CM binds to PCA-g-PCL copolymers via electrostatic interaction to form polyion complex micelles with a hydrophilic PEG surface, which enhances the stability of micelles in aqueous media. mPEG2000-CM can be used for drug delivery .
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-
- HY-D1993
-
|
|
Fluorescent Dye
HIV
|
Infection
|
|
ATTO 647 NHS ester is a fluorescent label targeting free amino groups. ATTO 647 NHS ester can undergo a nucleophilic reaction with the free amino groups of EF-C peptide via its activated carboxylic acid group to form a stable covalent conjugate. ATTO 647 NHS ester-labeled nanofibers not only retain retroviral transduction-enhancing activity but also maintain stable fluorescent signals in both buffer and cell culture systems. ATTO 647 NHS ester is suitable for detection applications including fluorescence spectroscopy, microscopy and flow cytometry. ATTO 647 NHS ester has been used in studies related to HIV-1 infection .
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-
- HY-W591390
-
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Biochemical Assay Reagents
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Others
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|
6-Azidohexanoic Acid STP Ester is an amine-reactive, water-soluble labeling reagent with an azide group and a terminal 4-Sulfo-2,3,5,6-tetrafluorophenyl (STP) group. 6-Azidohexanoic Acid STP Ester is used to modify proteins, antibodies, and other amine-containing biopolymers in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. STP esters can react with primary amines, forming covalent amide bonds, and typically display much better stability toward hydrolysis in aqueous media, resulting in more efficiency and better reproducible labeling of biopolymers.
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-
- HY-100216R
-
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SPDP Crosslinker (Standard); Py-ds-Prp-OSu (Standard)
|
ADC Linker
Reference Standards
|
Cancer
|
|
SPDP (Standard) is the analytical standard of SPDP (HY-100216). This product is intended for research and analytical applications. SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs) .
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-
- HY-34502
-
|
6-Indolecarbonitrile
|
Biochemical Assay Reagents
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Others
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|
6-Cyanoindole is a biochemical reagent that can be used as a biological material or organic compound for life science related research. 6-Cyanoindole is a significant indole derivative for the electron-withdrawing -C≡N group. 6-Cyanoindole can be used to generate a copolymer P(6CNIn-co-EDOT) via electrocopolymerization with EDOT .
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- HY-151829
-
|
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ADC Linker
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Others
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Fmoc-L-Asn(EDA-N3)-OH is a click chemistry reagent containing an azide group. This building block is reported in literature for the modification of Amanitin via Click Chemistry. Alpha-Amanitin is the deadliest member of the amatoxin peptide family produced by the death-cap mushroom A. phalloides. It is an orally available, rigid, bicyclic octapeptide and one of the most lethal known natural products (LD50 = 50-100 μg/kg) acting as highly selective allosteric inhibitor of the RNA polymerase II . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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-
- HY-134222A
-
|
N-Acetyl-L-serine
|
Endogenous Metabolite
Complement System
|
Others
|
|
N-Acetylserine (N-Acetyl-L-serine) is a complement pathway modulator targeting activated third complement protein (C3b) and an amino-terminal residue (an N-terminal acetylation modification group). N-Acetylserine reacts with the exposed thioester group of C3b via its hydroxyl group, thereby blocking the covalent binding of glycerol to this thioester group. N-Acetylserine widely exists in soluble proteins of mammalian cells (accounting for approximately 80% of such proteins). N-Acetylserine has a blocking property that prevents direct Edman sequencing of proteins; deblocking is achievable through trifluoroacetic acid-catalyzed N→O acetyl migration followed by β-elimination. N-Acetylserine is suitable for sequencing of proteins with N-terminal acetylserine modification .
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-
- HY-174929
-
|
DBCO-PEG3400-NH2
|
Biochemical Assay Reagents
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Others
|
|
DBCO-PEG3400-Amine (DBCO-PEG3400-NH2) is a polyethylene glycol derivative containing dibenzocyclooctyne. DBCO-PEG-Amine is a universal, modular "bridge molecule": it forms stable covalent linkage with target materials (e.g., MSN or polymers) via the amino group at one end, while the DBCO group at the other end enables efficient, specific, and biocompatible click chemical conjugation with any azide-bearing biological entities (e.g., bacteria, cells) in subsequent steps .
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-
- HY-116423A
-
|
|
NEKs
|
Cancer
|
|
JH295 hydrate is a potent, irreversible and selective NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 770 nM. JH295 hydrate inhibits cellular Nek2 via alkylation of Cys22. JH295 hydrate is inactive against the mitotic kinases, Cdk1, Aurora B or Plk1, and does not perturb bipolar spindle assembly or the spindle assembly checkpoint . JH295 (hydrate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
- HY-182784
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 336 is an antibacterical agent with broad-spectrum inhibitory activity against Gram-negative and Gram-positive bacteria. Antibacterial agent 336 binds tightly via its pyridine group to the carboxyl group, Lys-465 residue, and Leu-480 residue of the MsbA protein, interfering with bacterial outer membrane synthesis, and exerts concentration-dependent bactericidal activity against bacterial. Antibacterial agent 336 has low cytotoxicity to normal human liver cells. Antibacterial agent 336 can be used for the research of bacterial infections .
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-
- HY-140678
-
|
mPEG10000-NH2
|
PROTAC Linkers
|
Cancer
|
|
DBCO-PEG10000-Amine (DBCO-PEG10000-NH2) is a polyethylene glycol derivative containing dibenzocyclooctyne. DBCO-PEG-Amine is a universal, modular "bridge molecule": it forms stable covalent linkage with target materials (e.g., MSN or polymers) via the amino group at one end, while the DBCO group at the other end enables efficient, specific, and biocompatible click chemical conjugation with any azide-bearing biological entities (e.g., bacteria, cells) in subsequent steps .
|
-
- HY-107453
-
|
PROTAC Sirt2-binding moiety 1
|
Ligands for Target Protein for PROTAC
|
Cancer
|
|
SirReal1-O-propargyl is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC50 of 2.4 μM. SirReal1-O-propargyl, the SirReal1-based moiety, binds to the cereblon ligand via a linker to form PROTAC to degrade Sirt2 . SirReal1-O-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-174929A
-
|
DBCO-PEG5000-NH2
|
Biochemical Assay Reagents
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Others
|
|
DBCO-PEG5000-Amine (DBCO-PEG5000-NH2) is a polyethylene glycol derivative containing dibenzocyclooctyne. DBCO-PEG-Amine is a universal, modular "bridge molecule": it forms stable covalent linkage with target materials (e.g., MSN or polymers) via the amino group at one end, while the DBCO group at the other end enables efficient, specific, and biocompatible click chemical conjugation with any azide-bearing biological entities (e.g., bacteria, cells) in subsequent steps .
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-
- HY-116423
-
|
|
NEKs
|
Cancer
|
|
JH295 is a potent, irreversible and selective NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 770 nM. JH295 inhibits cellular Nek2 via alkylation of Cys22. JH295 is inactive against the mitotic kinases, Cdk1, Aurora B or Plk1, and does not perturb bipolar spindle assembly or the spindle assembly checkpoint . JH295 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
- HY-D3325
-
|
|
Fluorescent Dye
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Others
|
|
AF 700 NHS ester is a fluorescent dye AF 700 derivative exhibits high fluorescence quantum yield and high photostability. AF 700 NHS ester can form an ester bond with ammonia via the NHS group, and can be used to label proteins, amine-modified oligonucleotides, and other primary amines (R-NH2) containing amine molecules (Ex/Em = 702/723 nm).
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-
- HY-D3257
-
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Fluorescent Dye
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Others
|
|
AF 546 NHS ester is a fluorescent dye AF 546 derivative exhibits high fluorescence quantum yield and high photostability. AF 546 NHS ester can form an ester bond with ammonia via the NHS group, and can be used to label proteins, amine-modified oligonucleotides, and other primary amines (R-NH2) containing amine molecules (Ex/Em = 554/570 nm).
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-
- HY-105129R
-
|
|
Reference Standards
Others
|
Cancer
|
|
Pimonidazole (hydrochloride) (Standard) is the analytical standard of Pimonidazole (hydrochloride). This product is intended for research and analytical applications. Pimonidazole is a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in tumor . Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after reduction of its nitro group, it can be used for qualitative and quantitative assessment of tumor hypoxia .
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-
- HY-105129AR
-
|
|
Reference Standards
Others
|
Cancer
|
|
Pimonidazole (Standard) is the analytical standard of Pimonidazole. This product is intended for research and analytical applications. Pimonidazole is a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in tumor . Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after reduction of its nitro group, it can be used for qualitative and quantitative assessment of tumor hypoxia .
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-
- HY-D3259
-
|
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Fluorescent Dye
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Others
|
|
AF 680 NHS ester is a fluorescent dye AF 680 derivative exhibits high fluorescence quantum yield and high photostability. AF 680 NHS ester can form an ester bond with ammonia via the NHS group, and can be used to label proteins, amine-modified oligonucleotides, and other primary amines (R-NH2) containing amine molecules (Ex/Em = 684/707 nm).
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-
- HY-D3326
-
|
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Fluorescent Dye
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Others
|
|
AF 750 NHS ester is a fluorescent dye AF 750 derivative exhibits high fluorescence quantum yield and high photostability. AF 750 NHS ester can form an ester bond with ammonia via the NHS group, and can be used to label proteins, amine-modified oligonucleotides, and other primary amines (R-NH2) containing amine molecules (Ex/Em = 753/782 nm).
|
-
- HY-W165085
-
|
Decamethylenebispyridinium dibromide
|
Cholinesterase (ChE)
|
Neurological Disease
|
|
1,10-Bis(pyridinium)decane (Decamethylenebispyridinium dibromide) is an acetylcholinesterase (AChE) inhibitor with an IC50 of 25.8 nM. 1,10-Bis(pyridinium)decane acts as a bis-quaternary ligand that bridges the enzyme's catalytic site and peripheral site via its two pyridinium groups. 1,10-Bis(pyridinium)decane can be used for the research of alzheimer's disease .
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-
- HY-D3323
-
|
|
Fluorescent Dye
|
Others
|
|
AF 350 NHS ester is a fluorescent dye AF 350 derivative exhibits high fluorescence quantum yield and high photostability. AF 350 NHS ester can form an ester bond with ammonia via the NHS group, and can be used to label proteins, amine-modified oligonucleotides, and other primary amines (R-NH2) containing amine molecules (Ex/Em = 346/445 nm) .
|
-
- HY-D3258
-
|
|
Fluorescent Dye
|
Others
|
|
AF 660 NHS ester is a fluorescent dye AF 660 derivative exhibits high fluorescence quantum yield and high photostability. AF 660 NHS ester can form an ester bond with ammonia via the NHS group, and can be used to label proteins, amine-modified oligonucleotides, and other primary amines (R-NH2) containing amine molecules (Ex/Em = 668/698 nm).
|
-
- HY-D3256
-
|
|
Fluorescent Dye
|
Others
|
|
AF 532 NHS ester is a fluorescent dye AF 532 derivative exhibits high fluorescence quantum yield and high photostability. AF 532 NHS ester can form an ester bond with ammonia via the NHS group, and can be used to label proteins, amine-modified oligonucleotides, and other primary amines (R-NH2) containing amine molecules (Ex/Em = 530/555 nm).
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-
- HY-125986
-
|
|
Phospholipase
|
Neurological Disease
|
GK187 is a potent and selective Group VIA calcium-independent phospholipase A2 (GVIA iPLA2) inhibitor with an XI(50) value of 0.0001. GK187 can be used for researching various neurological disorders .
[The XI(50) is the mole fraction of the inhibitor in the total substrate interface required to inhibit the enzyme by 50%.]
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-
- HY-W190943
-
|
|
Drug-Linker Conjugates for ADC
|
Cancer
|
|
Azido-PEG4-Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the cleavable linker Azido-PEG4-Val-Cit-PAB-OH . Azido-PEG4-Val-Cit-PAB-MMAE is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-130086
-
|
|
ADC Linker
|
Cancer
|
|
Bis-PEG4-NHS ester is a crosslinking reagent and amine-reactive modulator .Bis-PEG4-NHS ester reacts with primary amine groups on liposome surfaces via amide bond formation to covalently attach dibenzylcyclooctyne groups, with a hydrophilic PEG4 spacer reducing steric hindrance for subsequent click chemistry .Bis-PEG4-NHS ester enables site-specific antibody coupling to liposome surfaces via copper-free strain-promoted alkyne-azide cycloaddition click chemistry without disrupting liposome structure in minimal organic solvent volumes .Bis-PEG4-NHS ester undergoes hydrolysis during annealing to form -COOH groups that interact with PbI and FAI to enhance perovskite structural integrity, passivate defects, and modulate nucleation kinetics to regulate crystal growth .Bis-PEG4-NHS ester enhances device efficiency and long-term stability when used as an antisolvent additive for p-i-n perovskite solar cells .
|
-
- HY-P2770B
-
|
|
Biochemical Assay Reagents
|
Metabolic Disease
|
|
β-Amylase, Barley (EC 3.2.1.2) hydrolyzes the α-(1,4) glucan bonds in polysaccharides composed of three or more α-(1,4)-linked D-glucan units. In the absence of a reducing agent, β-Amylase, Barley (EC 3.2.1.2) rapidly polymerizes via thiol groups.
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-
- HY-P10646
-
|
|
Biochemical Assay Reagents
|
Neurological Disease
|
|
Muscle homing peptide M12 can preferentially bind to surface protein of muscle cells. Muscle homing peptide M12 mediates enhanced cellular uptake of nanoparticles (NPs) in myoblasts in vitro. Muscle homing peptide M12 is covalently conjugated to PLGA-PEG NPs via the N-terminal α-amino groups of peptides using the N-hydroxysuccinimide ester reaction .
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-
- HY-D2165
-
|
|
Fluorescent Dye
|
Others
|
|
AF 594 streptavidin is a bioconjugating agent. It consists of AF 594 and streptomycin, a streptomycin derivative of the red fluorescent dye AF 594. AF 594 has high fluorescence quantum yield and high photostability (Ex=594 nm, Em=615 nm). AF 594 streptavidin can be selectively conjugated to streptavidin-modified molecules via a streptomycin-modifying group for fluorescent labeling and spectroscopic analysis .
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-
- HY-160258
-
|
GDP-Fucose-Am-Tz
|
Biochemical Assay Reagents
|
Others
|
|
GDP-Fucose-Tz (GDP-Fucose-Am-Tz) is a non-natural GDP-fucose analog bearing a Tetrazine group. As a precursor, GDP-Fucose-Tz enables the synthesis of GDP-fucose-ssDNA probes via inverse electron demand Diels-Alder reaction. GDP-Fucose-Tz participates in chemoenzymatic reactions to prepare GDP-fucose-Herceptin derivatives through conjugation with TCO-Herceptin .
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-
- HY-D2381
-
|
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Fluorescent Dye
|
Others
|
|
AF 488 maleimide is a thiol-reactive dye used to label SH groups of proteins, which can attach the AF 488 fluorophore to cysteine residue-containing proteins and peptides as well as other thiolated molecules. AF 488 maleimide enables real-time visualization of dynamic pilus extension and retraction in live bacterial cells via epifluorescence microscopy (Ex/Em = 470/520 nm) .
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-
- HY-151679
-
|
|
ADC Linker
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Others
|
|
Fmoc-L-Lys(4-N3-Z)-OH is a click chemistry reagent containing an azide group. Fmoc-L-Lys(4-N3-Z)-OH acts as Lysine building-block for SPPS containing an Azide moiety as a bioorthogonal ligation handle, an infrared probe and a photo-affinity reagent. It can be decaged by trans-cyclooctenols via a strain-promoted 1,3-dipolar cycloaddition . Fmoc-L-Lys(4-N3-Z)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-32933
-
|
|
Carbonic Anhydrase
|
Metabolic Disease
|
|
4-Acetylphenylboronic acid is a potent inhibitor of carbonic anhydrases II(CA II), with IC50s of 246 μM and 281.40 μM for bovine CA II (bCA II) and human CA II (hCA II). 4-Acetylphenylboronic acid can be obtained via mechanochemistry and solvent evaporation. 4-Acetylphenylboronic acid has a loss of the carbonyl group at 500-550 K .
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-
- HY-P2975
-
|
Mouse laminin (Engelbreth-Holm-Swarm murine sarcoma basement membrane)
|
Endogenous Metabolite
Biochemical Assay Reagents
|
Neurological Disease
|
|
Laminin (Engelbreth-Holm-Swarm murine sarcoma basement membrane) is a crucial structural element in animal tissues, forming part of the scaffolding that supports tissue architecture. It interacts with type IV collagen through entactin and perlecan, connects to cell membranes via integrin receptors, dystroglycan complexes, and Lutheran blood group glycoproteins, and contains functional domains that facilitate collagen binding, cell adhesion, heparin interaction, and promote neurite outgrowth.
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-
- HY-165427
-
|
|
Liposome
|
Cancer
|
|
Lipid 11 (Compound Lipid 1) is a cationic lipid for nucleic acid delivery. Lipid 11 forms lipid nanoparticles (LNPs) through electrostatic binding with nucleic acids (such as ceDNA). Lipid 11 forms complexes with negatively charged nucleic acids via cationic amine groups, which can be endocytosed by cells to release nucleic acids for activity. Lipid 11 is promising for research of gene therapy drug delivery systems .
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-
- HY-147168
-
|
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Biochemical Assay Reagents
|
Others
|
|
Biocytin hydrazide is a long-chain biotin-containing hydrazide, serving as a biotin-derived active coupling reagent, selective labeling agent and biotinylating reagent. Biocytin hydrazide targets aldehyde, carboxyl, amino and guanidino groups to biotinylate glycoconjugates, K99 lectin, peptides and proteins through its hydrazide moiety, and achieves nonradioactive detection of sialic acid- and galactose-containing glycoconjugates via the avidin–biotin system .
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-
- HY-151704
-
|
|
Fluorescent Dye
|
Cancer
|
|
ICG-alkyne is a short-wave infrared (SWIR)-emitting cyanine fluorescent probe based on alkyne-derivatized indocyanine green. ICG-alkyne can undergo click chemistry reaction to conjugate with antibody molecules via binding to the azide groups introduced into antibodies. ICG-alkyne enables SWIR fluorescent molecular imaging of breast tumors in living mice. ICG-alkyne can be used in breast cancer-related research .
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-
- HY-133022R
-
|
(E)-2-Undecenoic acid (Standard); (E)-Undec-2-enoic acid (Standard)
|
Reference Standards
Drug Isomer
|
Metabolic Disease
|
|
trans-2-Undecenoic acid (Standard) is the analytical standard of trans-2-Undecenoic acid. This product is intended for research and analytical applications. trans-2-Undecenoic acid ((E)-2-Undecenoic acid) is an α,β-unsaturated carboxylic acid and is characterized by acid dimers. The corresponding dimers are connected via intermolecular hydrogen bonds of the carboxylic groups C=O···H-O[1].
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-
- HY-131088
-
|
|
Drug-Linker Conjugates for ADC
EGFR
|
Cancer
|
|
N3-PEG8-Phe-Lys-PABC-Gefitinib is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-tumor agent, Gefitinib (HY-50895) (orally active EGFR tyrosine kinase inhibitor), linked via the cleavable linker N3-PEG8-Phe-Lys-PABC. N3-PEG8-Phe-Lys-PABC-Gefitinib is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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-
- HY-W800703
-
|
|
Fluorescent Dye
|
Others
|
|
Alexa Fluor 594 azide is an azide-modified fluorescent dye and also a FRET acceptor reactant. Owing to its negligible direct absorption under 488 nm excitation light, excellent photostability, and the ability of its azide group to participate in the CuAAC reaction, Alexa Fluor 594 azide can be paired with a donor dye for single-molecule imaging via TIRFM, thereby enabling the visual monitoring of CuNP-catalyzed click reactions .
|
-
- HY-116879
-
|
(2E)-4-Oxo-2-nonen-8-ynal; alkynyl-4-ONE
|
Exosomes
Others
|
Cancer
|
|
4-Oxo-2-Nonenal Alkyne ((2E)-4-Oxo-2-nonen-8-ynal; alkynyl-4-ONE) is a functionalized lipid electrophile that conjugated to the exosomes via the reaction of amino and aldehyde groups. 4-Oxo-2-Nonenal Alkyne can be used in tumor exosomes determination .
|
-
- HY-W800618
-
|
|
ADC Linker
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Others
|
|
NH2-PEG3-Val-Cit-PAB-OH is a cleavable ADC linker featuring a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The primary amine is free to perform a wide variety of reactions such as coupling with carboxylic acids, reductive aminations with ketones or aldehydes, or other more specialized uses such as in SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery via an elimination mechanism within the PAB structure.
|
-
- HY-W800617
-
|
|
ADC Linker
|
Cancer
|
|
NH2-PEG1-Val-Cit-PAB-OH is a cleavable ADC linker intermediate featuring a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The primary amine is free to perform a wide variety of reactions such as coupling with carboxylic acids, reductive aminations with ketones or aldehydes, or other more specialized uses such as in SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery via an elimination mechanism within the PAB structure.
|
-
- HY-W800619
-
|
|
ADC Linker
|
Others
|
|
NH2-PEG4-Val-Cit-PAB-OH is a cleavable ADC linker featuring a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The primary amine is free to perform a wide variety of reactions such as coupling with carboxylic acids, reductive aminations with ketones or aldehydes, or other more specialized uses such as in SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery via an elimination mechanism within the PAB structure.
|
-
- HY-W800620
-
|
|
ADC Linker
|
Others
|
|
NH2-PEG6-Val-Cit-PAB-OH is a cleavable ADC linker featuring a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The primary amine is free to perform a wide variety of reactions such as coupling with carboxylic acids, reductive aminations with ketones or aldehydes, or other more specialized uses such as in SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery via an elimination mechanism within the PAB structure.
|
-
- HY-W024881
-
|
2,3,3-Trimethylindolenine-5-sulfonic acid potassium salt
|
Drug Intermediate
|
Others
|
|
Potassium 2,3,3-trimethylindole-5-sulfonate (2,3,3-Trimethylindolenine-5-sulfonic acid potassium salt) is an indole derivative containing a sodium sulfonate group and is commonly used as a key intermediate in dye synthesis. Potassium 2,3,3-trimethylindole-5-sulfonate can be coupled to peptides, proteins, nucleic acids, RNA, DNA, carbohydrates, polymers, and small molecules via the sulfonyl substituent .
|
-
- HY-131088A
-
|
|
Drug-Linker Conjugates for ADC
EGFR
|
Cancer
|
|
N3-PEG8-Phe-Lys-PABC-Gefitinib TFA is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-tumor agent, Gefitinib (HY-50895) (orally active EGFR tyrosine kinase inhibitor), linked via the cleavable linker N3-PEG8-Phe-Lys-PABC. N3-PEG8-Phe-Lys-PABC-Gefitinib TFA is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-W012166
-
|
NHS-Bromoacetate
|
Biochemical Assay Reagents
|
Infection
|
|
N-Succinimidyl bromoacetate (NHS-Bromoacetate) is a heterobifunctional crosslinking reagent, mainly used to modify the ɛ-amino group of lysine side chains. By covalently linking its bromoacetyl moiety to the ɛ-amino group of lysine in peptidomimetics, N-Succinimidyl bromoacetate enables their conjugation with thiol-modified nanoparticles via thioether bonds. N-Succinimidyl bromoacetate also performs bromoacetylation modification on carrier proteins, which then forms stable thioether bonds with the thiol groups of cysteine in peptides, thus efficiently preparing soluble peptide-protein conjugates with high substitution ratios. N-Succinimidyl bromoacetate can be used to prepare activated Sepharose derivatives for affinity chromatography, protein affinity labeling reagents, and peptide-protein immunogen conjugates with non-immunogenic linkages. N-Succinimidyl bromoacetate is applicable to studies related to HIV-1 infection and glioblastoma multiforme .
|
-
- HY-176241
-
|
|
Others
|
Cardiovascular Disease
|
|
DC-174 is an orally active inhibitor of snake venom metalloproteinases (SVMP) with a broad spectrum of inhibitory activity against a variety of snake venom SVMPs. DC-174 acts directly on the active site of SVMPs via zinc-binding groups, inhibiting their enzymatic activity and procoagulant toxicity. DC-174 can significantly prolong the survival time of mice attacked by snake venom. DC-174 can be used in the study of first aid for snake bites .
|
-
- HY-W1048851B
-
|
4-Arm-PEG10000-Mal
|
Biochemical Assay Reagents
|
Others
|
|
4-Arm-PEG10000-Maleimide (4-Arm-PEG10000-Mal) is a four-arm star-shaped multifunctional PEG crosslinker with an average molecular weight of 10 kDa and maleimide terminal groups. 4-Arm-PEG10000-Maleimide efficiently conjugates biomolecules via thiol-Michael reaction, and is widely used in protein modification, antibody-drug conjugation and biomaterial preparation .
|
-
- HY-B0952
-
|
Tuaminoheptane
|
Adrenergic Receptor
|
Neurological Disease
|
|
2-Aminoheptane (Tuaminoheptane) is a norepinephrine transporter inhibitor. 2-Aminoheptane binds to norepinephrine transporter via ionic and hydrophobic interactions to block norepinephrine uptake. 2-Aminoheptane deactivates ω-TAmla enzyme, reduces recombinant whole cell stability, and acts as an amino group donor substrate for ω-TA and ω-TAmla enzymes. 2-Aminoheptane can be used in research on depression and Alzheimer's disease .
|
-
- HY-P11781A
-
|
|
Drug Derivative
|
Cancer
|
|
Cys-HW12 is a random peptide containing an N-terminal cysteine. Cys-HW12 can be coupled via the thiol group of Cys. Cys-HW12 can serve as a control for GE11 (HY-P10128)-conjugated mixed micelles targeting EGFR, and also functions as a cytotoxic agent, cellular uptake inhibitor, and tumor growth inhibitor. Cys-HW12 is applicable to pancreatic cancer-related research .
|
-
- HY-P5057B
-
|
|
Fluorescent Dye
Bacterial
|
Infection
|
|
5-FAM-Ahx-LL-37 TFA is a 5-FAM (HY-66022) labeled LL-37, human (HY-P1222). The carboxyfluorescein group is attached via a 6-carbon spacer, 6-Aminohexanoic acid (Ahx, HY-B0236). LL-37, human is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity .
|
-
- HY-101532
-
|
β-CDN3; 6A-deoxy-6A-azido-β-cyclodextrin
|
Biochemical Assay Reagents
|
Others
|
|
6A-Azido-6A-deoxy-β-cyclodextrin (β-CDN3) is a site-specifically modified β-cyclodextrin with a single azido group replacing the hydroxyl group at the C6 position. 6A-Azido-6A-deoxy-β-cyclodextrin forms a host-guest inclusion complex with Dexamethasone (HY-14648), localizing the drug within its hydrophobic cavity, which restricts the rotational mobility of the drug and places Dexamethasone in a less polar environment. 6A-Azido-6A-deoxy-β-cyclodextrin acts as a coupling agent to graft β-cyclodextrin onto thermosensitive nanogels via strain-promoted alkyne-azide cycloaddition (SPAAC). 6A-Azido-6A-deoxy-β-cyclodextrin also serves as a click chemistry reagent. It contains an azide group and undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules bearing an alkyne group. It also undergoes strain-driven alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups .
|
-
- HY-107442R
-
|
|
Reference Standards
Epigenetic Reader Domain
Ligands for Target Protein for PROTAC
|
Cancer
|
|
PROTAC BRD4-binding moiety 1 (Standard) is the analytical standard of PROTAC BRD4-binding moiety 1 (HY-107442). This product is intended for research and analytical applications. PROTAC BRD4-binding moiety 1 is a ligand for BRD4. PROTAC BRD4-binding moiety 1 binds to cereblon ligand via a linker to form PROTAC to degrade BRD4 (HY-133136) . PROTAC BRD4-binding moiety 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-P11772
-
|
|
Bacterial
|
Infection
|
|
LBP-14, a peptide, is a synthetic fragment of the LPS (HY-D1056) binding protein (LBP) and is a LPS antagonist. LBP-14 interacts with LPS via electrostatic contacts between arginine/lysine residues and LPS phosphate groups, and hydrophobic contacts between aromatic/aliphatic residues and LPS acyl chains, blocking LPS binding to LBP. LBP-14 moderately inhibits LPS-induced TNF-α formation. LBP-14 can be used for the research of gram-negative sepsis .
|
-
- HY-150726
-
|
|
Toll-like Receptor (TLR)
Bacterial
|
Infection
Neurological Disease
Inflammation/Immunology
|
|
ODN 1668, a class B CpG ODN (oligodeoxynucleotide), is a TLR-9 agonist. ODN 1668 has strong immune regulatory properties, can enhance the level of antibody IgG2 subtype, promote the immune response of T cells and B cells, and can be used in the study of vaccine adjuvants. In addition, CpG ODN 1668 induces an antimicrobial immune response via a CaTLR9 dependent pathway in groupers. Sequence: 5'-tccatgacgttcctgatgct-3’ .
|
-
- HY-W1119956
-
|
5'(E)-VP-2'-OMe-iBu-G
Phosphoramidite
|
Nucleoside Antimetabolite/Analog
DNA/RNA Synthesis
|
Infection
|
|
5'-(E)-VPG Phosphoramidite (5'(E)-VP-2'-OMe-iBu-GPhosphoramidite) is a structurally modified phosphoramidite reagent used to synthesize biologically stable oligonucleotides. 5'-(E)-VPG Phosphoramidite (POM) carries a VP protecting group and can be coupled to the target oligonucleotide at the 5' end via solid-phase synthesis. The modified oligonucleotide is then constructed through oxidation and deprotection steps. 5'-(E)-VPG Phosphoramidite is suitable for RNAi and viral replication research .
|
-
- HY-186088
-
|
|
Drug Intermediate
|
Others
|
|
DOTA-tris (t-Bu) ester-PEG3-C2-amine (Compound 9) is a conjugate of DOTA-based chelator and linker, bearing tris (t-Bu) ester and PEG3-C2-amine functional groups. DOTA-tris (t-Bu) ester-PEG3-C2-amine can be conjugated to payloads via bioorthogonal click chemistry for targeted delivery .
|
-
- HY-W016586R
-
|
AT-125 (Standard); U-42126 (Standard)
|
Reference Standards
Parasite
γ-Glutamyl Transferase (GGT)
|
Infection
Cancer
|
|
Articaine (Standard) is the analytical standard of Articaine. This product is intended for research and analytical applications. Articaine (Hoe-045 free base) is an amide agent that can suppress or relieve pain. containing an ester group, reversibly binding to the α-subunit of the voltage-gated sodium channels within the inner cavity of the nerve, can provide effective pain relief. Articaine ameliorates LPS-induced acute kidney injury via inhibition of NF-κB activation and the NLRP3 inflammasome pathway .
|
-
- HY-150726C
-
|
|
Toll-like Receptor (TLR)
Bacterial
|
Infection
Neurological Disease
Inflammation/Immunology
|
|
ODN 1668 sodium, a class B CpG ODN (oligodeoxynucleotide), is a TLR-9 agonist. ODN 1668 sodium has strong immune regulatory properties, can enhance the level of antibody IgG2 subtype, promote the immune response of T cells and B cells, and can be used in the study of vaccine adjuvants. In addition, CpG ODN 1668 sodium induces an antimicrobial immune response via a CaTLR9 dependent pathway in groupers. Sequence: 5'-tccatgacgttcctgatgct-3’ .
|
-
- HY-N3018
-
|
6-O-α-D-Glucopyranosyl-D-glucose; D-Isomaltose
|
Endogenous Metabolite
Parasite
|
Infection
Metabolic Disease
|
|
Isomaltose (6-O-α-D-Glucopyranosyl-D-glucose) is a glucose disaccharide. Isomaltose induces G-CSF secretion via heat-induced oxidative polymerization of glucose groups into high-molecular-weight compounds. Isomaltose modulates cecal bacterial cluster structure in mice. Isomaltose exhibits low glycemic index, slow hydrolysis, and prebiotic properties. Isomaltose reduces in vivo Cryptosporidium parvum colonization in neonatal mice. Isomaltose can be used for the research of Cryptosporidium parvum infection .
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-
- HY-182754
-
|
|
SARS-CoV
Virus Protease
|
Infection
|
|
SARS-CoV-2 Mpro-IN-57 is an irreversible SARS-CoV-2 main protease inhibitor with an IC50 of 0.41 μM and a Kd of 247.37 nM. SARS-CoV-2 Mpro-IN-57 forms a covalent bond with the key amino acid residue Cys145 in SARS-CoV-2 main protease via its -CN group. SARS-CoV-2 Mpro-IN-57 can be used for the research of COVID-19 .
|
-
- HY-D0874
-
|
|
Biochemical Assay Reagents
|
Others
|
|
HEPPSO is a zwitterionic Good's buffer suitable for physiological pH conditions. HEPPSO forms high-order oligomers in aqueous solutions and can form a 1:1 complex with Cu 2+ via its hydroxyalkyl and tertiary amine groups. However, HEPPSO contains a structurally similar trace impurity lacking an alkanesulfonic acid side chain. The complex formed by this impurity and Cu 2+ has a very low Ka; therefore, HEPPSO may interfere with studies on copper speciation analysis in natural water bodies .
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-
- HY-W090309
-
|
|
Biochemical Assay Reagents
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Others
|
|
Monosodium 2-sulfoterephthalate is an oxygen-containing organic linker and coordination ligand. Under hydrothermal conditions, Monosodium 2-sulfoterephthalate binds to Cr 3+ ions via deprotonated carboxyl groups to form the MIL-101 (Cr)-SO3H metal-organic framework. Monosodium 2-sulfoterephthalate also adopts monodentate and hexadentate linkage modes with Er III ions, respectively, thereby forming monomeric and polymeric Er III compounds .
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-
- HY-135699
-
TD52
2 Publications Verification
|
Apoptosis
Phosphatase
Akt
|
Cancer
|
|
TD52, an Erlotinib (HY-50896) derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor. TD52 mediates the apoptotic effect in triple-negative breast cancer (TNBC) cells via regulating the CIP2A/PP2A/p-Akt signalling pathway. TD52 indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter. TD52 has less p-EGFR inhibition and has potent anti-cancer activity . TD52 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
- HY-135699A
-
|
|
Akt
Phosphatase
Apoptosis
|
Cancer
|
|
TD52 dihydrochloride, an Erlotinib (HY-50896) derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor. TD52 dihydrochloride mediates the apoptotic effect in triple-negative breast cancer (TNBC) cells via regulating the CIP2A/PP2A/p-Akt signalling pathway. TD52 dihydrochloride indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter. TD52 dihydrochloride has less p-EGFR inhibition and has potent anti-cancer activity . TD52 (dihydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
- HY-149449
-
|
|
Amino Acid Derivatives
|
Cancer
|
|
Poly-L-γ-glutamic acid sodium is a macromolecular polymer formed by the linkage of glutamic acid residues via peptide bonds between γ-amino and carboxyl groups. Poly-L-γ-glutamic acid sodium plays an important role as a carrier material in compound delivery systems. Poly-L-γ-glutamic acid sodium can deliver Paclitaxel (HY-B0015) to colon cancer cells, reduce cell viability and inhibit the growth of colon cancer spheroids. Poly-L-γ-glutamic acid sodium can be used as a carrier material and in studies related to colon cancer in mice .
|
-
- HY-N19808
-
|
|
Drug Derivative
|
Cancer
|
|
2-Deacetyl-4-tigloylchamissionolide is a heliangolide-type sesquiterpene lactone, a derivative of Chamissonolide (HY-N19727), and a cytotoxic agent. 2-Deacetyl-4-tigloylchamissionolide exerts cytotoxicity via alkylating biological nucleophiles, targeting free thiol groups in proteins to interfere with their functions. 2-Deacetyl-4-tigloylchamissionolide exhibits different chromatographic behaviors in TLC and HPLC. 2-Deacetyl-4-tigloylchamissionolide can be used for the research of Ehrlich ascites carcinoma .
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-
- HY-N3018R
-
|
6-O-α-D-Glucopyranosyl-D-glucose (Standard); D-Isomaltose (Standard)
|
Reference Standards
Endogenous Metabolite
Parasite
|
Infection
Metabolic Disease
|
|
Isomaltose (Standard) is the analytical standard of Isomaltose (HY-N3018). This product is intended for research and analytical applications. Isomaltose induces G-CSF secretion via heat-induced oxidative polymerization of glucose groups into high-molecular-weight compounds. Isomaltose modulates cecal bacterial cluster structure in mice. Isomaltose exhibits low glycemic index, slow hydrolysis, and prebiotic properties. Isomaltose reduces in vivo Cryptosporidium parvum colonization in neonatal mice. Isomaltose can be used for the research of Cryptosporidium parvum infection .
|
-
- HY-101530B
-
|
PEG 40 stearate
|
Biochemical Assay Reagents
|
Others
|
|
Polyoxyl 40 stearate (PEG 40 stearate) is a nonionic surfactant formed by the esterification of stearic acid with polyethylene glycol (PEG) containing approximately 40 ethoxy units, it is widely used in pharmaceutical preparations, nanodrug carriers, emulsification systems and biomedical materials. Polyoxyl 40 stearate can serve as a matrix component of solid lipid nanoparticles to achieve controlled release of encapsulated antifungal drugs; it can also act as a base material for solid lipid nanoparticles for vaginal administration, and polymerizable groups can be introduced via modification with acryloyl chloride .
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-
- HY-D3277
-
|
|
Fluorescent Dye
|
Others
|
|
PE-VF594 is a high-brightness fluorescent dye used in flow cytometry, primarily for labeling antibodies or streptavidin to help identify specific cell subpopulations. PE-VF594 is a tandem dye composed of two covalently linked fluorescent groups: one is phycoerythrin (PE), responsible for absorbing laser energy; the other is the receptor molecule VF594. Energy is transferred from PE to VF594 via fluorescence resonance energy transfer (FRET) mechanism (Ex/Em = 450-500 nm/614 nm) .
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-
- HY-185273
-
|
|
DNA/RNA Synthesis
|
Others
|
|
3'-O-(2-Nitrobenzyl)-dGTP is a reversible terminator. 3'-O-(2-Nitrobenzyl)-dGTP can be recognized and incorporated by DNA polymerases, thereby temporarily terminating DNA primer extension; after the 2-nitrobenzyl blocking group is removed via laser irradiation, a free 3'-OH can be regenerated to allow subsequent polymerase-mediated extension. 3'-O-(2-Nitrobenzyl)-dGTP can be used in DNA sequencing studies .
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-
- HY-149203A
-
|
|
Fluorescent Dye
|
Others
|
|
MQA-P is a multifunctional near-infrared (NIR) fluorescent probe that simultaneously detects ONOO -, viscosity, and polarity within mitochondria. MQA-P exhibits significant response to ONOO -, λem=645 nm; and NIR channel at λem>704 nm Medium is highly sensitive to viscosity/polarity. MQA-P possesses excited-state intramolecular charge transfer (ESICT) properties that are highly sensitive to polarity by designing the N,N-dimethylamino group as the electron donor and the quinoline cation unit as the electron acceptor. MQA-P is used for ferroptosis or cancer diagnosis in vitro and in vivo via dual-channel images .
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-
- HY-B0368B
-
|
|
Beta-lactamase
Antibiotic
Bacterial
|
Infection
Inflammation/Immunology
|
|
D-Captopril is a NDM-1 inhibitor and a competitive BlaB inhibitor, with an IC50 value of 21.8 µM against NDM-1 and a Ki of 70-100 µM against BlaB. D-Captopril synergistically reduces the minimum inhibitory concentration of Meropenem (HY-13678) against NDM-1-expressing bacteria. D-Captopril binds to BcII via its thiolate sulfur atom and carboxylate group, altering metal ion occupancy and modulating Cd 2+ binding affinity. D-Captopril can be used in the research of neonatal meningitis, sepsis and bacterial infections .
|
-
- HY-D3210
-
|
|
Fluorescent Dye
|
Inflammation/Immunology
|
|
DCM-KPV is a fluorescent probe targeting the human intestinal oligopeptide transporter PEPT1/SLC15A1 receptor (λex=480 nm, λem=620-670 nm). DCM-KPV specifically binds to PepT1 via its KPV domain and mediates receptor-targeted internalization, thus effectively accumulating in the cytoplasm and nucleus of cells overexpressing this receptor. DCM-KPV has the advantages of long emission wavelength, high emission efficiency, low photobleaching, and negligible cytotoxicity. DCM-KPV maintains stable fluorescence intensity under continuous illumination, exhibiting extremely high live cell compatibility. DCM-KPV can specifically accumulate at colonic inflammatory sites through the intestinal mucosa, enabling direct non-invasive visual differentiation between chronic and acute ulcerative colitis groups and the normal group .
|
-
- HY-B1829
-
|
Dexamethasone 21-phosphate
|
Glucocorticoid Receptor
TGF-β Receptor
Interleukin Related
|
Neurological Disease
Inflammation/Immunology
|
|
Dexamethasone phosphate (Dexamethasone 21-phosphate) is a prodrug form of the glucocorticoid Dexamethasone (HY-14648). Dexamethasone phosphate is prepared by introducing a phosphate ester group to the hydroxyl group at position 21 of the Dexamethasone molecule. Dexamethasone phosphate inhibits LPS (HY-D1056)-induced degradation of IRAK-1 and IRAK-4, and blocks LPS-induced activation of TRAF6, p-TAK1 and p-JNK. Dexamethasone phosphate inhibits the secretion of RANTES, TGF-β1 and NO, promotes the production of MIP-1α and IL-10, and blocks microglial migration. Dexamethasone phosphate is almost completely converted to Dexamethasone in rat blood, and supports transdermal delivery via iontophoresis. Dexamethasone phosphate can be used in research related to steroid-dependent ulcerative colitis, chemotherapy-induced vomiting, allergic asthma and acute colitis (inflammatory bowel disease) .
|
-
- HY-W020780
-
|
mPEG5000-Maleimide
|
Biochemical Assay Reagents
|
Cancer
|
|
mPEG5000-Mal (mPEG5000-Maleimide) is a PEG-derived selective covalent binding agent for sulfhydryl groups (RSGs), which can form irreversible thioether bonds with sulfhydryl groups under near-neutral conditions via the maleimide group. The mechanism of action of mPEG5000-Mal can be divided into two categories: firstly, as an enzyme modifier, it binds to target proteins through hydrophobic interactions, hydrogen bonds, and van der Waals forces, altering the protein's secondary structure; secondly, as a nanoparticle surface modifier, it covalently binds to sulfhydryl groups on the surface of red blood cells, changing the surface properties and morphology of the red blood cells, leading to their phagocytosis by macrophages of the reticuloendothelial system. mPEG5000-Mal can react with free cysteine in proteins, increasing the apparent molecular weight of the modified protein by 10-15 kDa for detection purposes. mPEG5000-Mal can enhance the thermal stability and catalytic activity of enzymes, and improve the macrophage targeting of nanoparticles, enabling targeted drug delivery. mPEG5000-Mal can be applied in enzyme engineering research in the food industry and in oncology, assisting radiotherapy by inhibiting tumor-associated macrophage infiltration and enhancing anti-tumor immune responses .
|
-
- HY-177901
-
|
|
DNA/RNA Synthesis
|
Others
|
|
3'-O-(2-Nitrobenzyl)-dATP is a reversible and photolabile DNA synthesis terminator. 3'-O-(2-Nitrobenzyl)-dATP incorporates into growing DNA strands to terminate synthesis in a base-specific manner. 3'-O-(2-Nitrobenzyl)-dATP undergoes efficient photolytic removal of its 3'-protecting group upon UV exposure to enable reinitiation of DNA synthesis. 3'-O-(2-Nitrobenzyl)-dATP supports development of the Base Addition Sequencing Scheme (BASS) via a complete stop-start DNA synthesis cycle .
|
-
- HY-Y0425
-
|
|
Drug Intermediate
Biochemical Assay Reagents
|
Others
|
|
Terephthalaldehyde is a crosslinking agent. Terephthalaldehyde forms a crosslinked structure inside the gelatin matrix by forming Schiff base imines with the amino groups of gelatin, thereby constructing a three-dimensional network. Terephthalaldehyde improves the hydrophobicity of the gelatin matrix, delays water vapor penetration and enhances the liquid water resistance of gelatin films. Terephthalaldehyde can be used as a crosslinking agent to prepare crosslinked chitosan hydrogel (CAAT) via ultrasound-induced synthesis. Terephthalaldehyde helps CAAT hydrogels selectively adsorb anionic dyes from aqueous media, including multi-component systems containing cationic dyes. Terephthalaldehyde serves as a starting material for the synthesis of bis-heterocyclic compounds (including bis-thiazole and bis-triazolopyrimidine compounds) .
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-
- HY-D1078
-
|
|
Fluorescent Dye
Reactive Oxygen Species (ROS)
P-glycoprotein
|
Others
|
|
5 (6)-Carboxy-2',7'-dichlorofluorescein diacetate is a fluorescein-based reactive oxygen species (ROS) probe and also a MRP2 substrate. 5 (6)-Carboxy-2',7'-dichlorofluorescein diacetate serves as a substrate for intracellular esterases, which cleave its acetate groups to generate a fluorescent product capable of detecting intracellular ROS. 5 (6)-Carboxy-2',7'-dichlorofluorescein diacetate is ATP-dependent and is transported via a single MRP2 binding site; it competes with LTC4 for MRP2 binding sites and inhibits MRP2-mediated LTC4 transport (Ex/Em = 496/525 nm) .
|
-
- HY-183038
-
|
|
Biochemical Assay Reagents
|
Others
|
|
2-Phenyl-1-octen-7-yn-1-one is an alkyne-functionalized enone with site-selective reactivity toward the N-terminal α-amino group of peptides and proteins. 2-Phenyl-1-octen-7-yn-1-one can undergo click chemistry with azides via its alkyne moiety to enable further protein functionalization. 2-Phenyl-1-octen-7-yn-1-one modifies unprotected peptide libraries as well as proteins including insulin, lysozyme, RNaseA and BCArg .
|
-
- HY-126192
-
|
PiB; 6-OH-BTA-1
|
Amyloid-β
|
Neurological Disease
|
|
Pittsburgh Compound B (PiB) is a blood-brain barrier-permeable, specific Aβ deposition PET tracer that binds to Aβ(1-40) fibrils with a Ki value of 678.4 nM. Through click chemical modification (a clickable Pittsburgh Compound B derivative is prepared by introducing a PEG3 linker and an alkynyl group at the 6-hydroxy site of Pittsburgh Compound B, followed by covalent conjugation with azide-labeled fluorescent dyes or affinity tags via copper-catalyzed azide-alkyne cycloaddition (CuAAC)), Pittsburgh Compound B and its conjugates can be used for fluorescence imaging, ultrastructural studies, and enrichment and characterization of Aβ complexes. Pittsburgh Compound B is applicable to Alzheimer's disease research .
|
-
- HY-B1829R
-
|
Dexamethasone 21-phosphate (Standard)
|
Glucocorticoid Receptor
Reference Standards
TGF-β Receptor
Interleukin Related
|
Neurological Disease
Inflammation/Immunology
|
|
Dexamethasone phosphate (Standard) (Dexamethasone 21-phosphate (Standard)) is the analytical standard of Dexamethasone phosphate (HY-B1829). This product is intended for research and analytical applications. Dexamethasone phosphate (Dexamethasone 21-phosphate) is a prodrug form of the glucocorticoid Dexamethasone (HY-14648). Dexamethasone phosphate is prepared by introducing a phosphate ester group to the hydroxyl group at position 21 of the Dexamethasone molecule. Dexamethasone phosphate inhibits LPS (HY-D1056)-induced degradation of IRAK-1 and IRAK-4, and blocks LPS-induced activation of TRAF6, p-TAK1 and p-JNK. Dexamethasone phosphate inhibits the secretion of RANTES, TGF-β1 and NO, promotes the production of MIP-1α and IL-10, and blocks microglial migration. Dexamethasone phosphate is almost completely converted to Dexamethasone in rat blood, and supports transdermal delivery via iontophoresis. Dexamethasone phosphate can be used in research related to steroid-dependent ulcerative colitis, chemotherapy-induced vomiting, allergic asthma and acute colitis (inflammatory bowel disease).
|
-
- HY-76440
-
|
Oxetan-3-one
|
Biochemical Assay Reagents
|
Others
|
|
3-Oxetanone (Oxetan-3-one) is a four-membered cyclic ketone and strained cyclic ether derivative with measurable molecular g-value, magnetic susceptibility anisotropy and molecular quadrupole moment. 3-Oxetanone acts not only as a hydrogen bond acceptor, a tetrel donor and a weak hydrogen bond acceptor, but also forms a classic O-H···O hydrogen bond with H2O via the ether oxygen atom. Alternatively, it forms a C···O tetrel bond with formaldehyde using its carbonyl group as a tetrel donor, while acting as a proton acceptor to form a C-H···O weak hydrogen bond with formaldehyde. 3-Oxetanone can be used to prepare various oxetanes .
|
-
- HY-114354
-
|
BOD FL alkyne
|
Fluorescent Dye
|
Inflammation/Immunology
|
|
BODIPY (BOD) FL alkyne is an alkyne-containing BODIPY fluorophore derivative. BODIPY FL alkyne is a bioorthogonal labeling reagent with low toxicity and extremely low non-specific reactivity, and it is widely used in fluorescent bioimaging. BODIPY FL alkyne specifically labels azide groups on intracellular glycoconjugates mainly via strain-promoted azide-alkyne cycloaddition (SPAAC), or mediates site-specific conjugation with proteins such as IL-33, and supports positive cross-linking with other probes (e.g., DBCO-SCy5) for dual labeling. With the advantages of high specificity and low background interference, BODIPY FL alkyne can be used in the research of related diseases such as asthma, atopic dermatitis and inflammatory bowel disease .
|
-
- HY-79587
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Benzil is a 1,2-diketone compound with multiple functions including photo-peroxidation initiator, crosslinking initiator and pattern-forming agent, and is commonly used as a precursor for photodegradable network crosslinkers. In oxygen-purged polymer films or glassy matrices, Benzil reacts with molecular oxygen under illumination at wavelengths greater than 370 nm or 400 nm, and converts to benzoyl peroxide in nearly quantitative yield. Subsequently, the generated benzoyl peroxide groups produce free radicals via thermal or photochemical decomposition, thereby enabling crosslinking of polymer chains, grafting of new monomers, and preparation of patterned polymers on solid surfaces using mask irradiation. Benzil also induces crosslinking of photodegradable poly (phenyl vinyl ketone) to form a stable photodegradable polymer network .
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-
- HY-D3181
-
|
|
Fluorescent Dye
Caspase
|
Cancer
|
|
CyGbPF is a granzyme B-specific near-infrared fluorescent probe. CyGbPF can be cleaved by granzyme B to remove the peptide cage group, restoring near-infrared fluorescence. CyGbPF passively accumulates in mouse tumors, and its activated fluorescence correlates with granzyme B expression, CD8 + cytotoxic T lymphocyte populations, and CD4 + helper T lymphocyte populations in tumor tissues. CyGbPF is efficiently cleared by the kidneys, enabling the assessment of immune activation via optical urine analysis. CyGbPF allows real-time non-invasive evaluation of cancer immunotherapeutic efficacy in living animals. CyGbPF can be used in research on cancers such as breast cancer. Excitation wavelength/emission wavelength: approximately 658 nm/approximately 717 nm .
|
-
- HY-156041
-
|
Lyso-PE (egg); LPE (egg); L-α-lysophosphatidylethanolamine
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Lysophosphatidylethanolamine (LPE) is a naturally-occurring lysophospholipid that can be generated via deacylation of phosphatidylethanolamine by phospholipase A2 (PLA2). It increases the phosphorylation of ERK1/2 in PC12 cells, an effect that can be blocked by the MEK inhibitors U-0126 (HY-12031A) and PD 98059 (HY-12028) and the EGFR inhibitor AG-1478 (HY-13524).1 LPE also increases neurite outgrowth and expression of neurofilament M in PC12 cells. LPE inhibits the activity of phospholipase D (PLD) partially purified from cabbage.3 This product contains lysophosphatidylethanolamine molecular species with variable fatty acyl chain lengths at the sn-1 position and a hydroxy group at the sn-2 position.
|
-
- HY-W996116
-
|
|
Glutathione Peroxidase
|
Cardiovascular Disease
Neurological Disease
Inflammation/Immunology
|
AZM198 is an orally active myeloperoxidase (MPO) inhibitor. AZM198 irreversibly inactivates MPO (IC50=0.015 μM) via covalent binding to the heme prosthetic group, preferentially targets extracellular MPO activity, and reduces neutrophil extracellular trap formation, reactive oxygen species production and degranulation. AZM198 increases the fibrous cap thickness of atherosclerotic plaques, reduces lesion area, ameliorates hepatic steatosis and fibrosis in non-alcoholic steatohepatitis, and alleviates proteinuria and inflammatory infiltration associated with glomerulonephritis. AZM198 also decreases circulating levels of high-sensitivity Cardiac Troponin I and IL-1β, and mitigates endothelial cell injury. Therefore, AZM198 is suitable for research on various MPO-related diseases, including atherosclerotic cardiovascular disease, myocardial infarction, ischemic stroke, non-alcoholic steatohepatitis and crescentic glomerulonephritis .
|
-
- HY-P2866
-
|
|
Endogenous Metabolite
Bacterial
|
Infection
Inflammation/Immunology
|
|
β-N-Acetylhexosaminidase, Streptococcus pneumoniae is a cell surface virulence factor of Streptococcus pneumoniae, which contains two synergistically acting GH20 domains (with higher activity in GH20-2). β-N-Acetylhexosaminidase, Streptococcus pneumoniae specifically recognizes and hydrolyzes substrates with β(1,2) glycosidic bonds via Trp-443 and Tyr-482 residues. β-N-Acetylhexosaminidase, Streptococcus pneumoniae catalyzes the hydrolysis of β(1,2)-linked N-acetylglucosamine groups and related disaccharides, and promotes persistent colonization of bacteria in the airway by modifying host defense molecules and releasing monosaccharides for bacterial growth. β-N-Acetylhexosaminidase, Streptococcus pneumoniae can be used in studies related to Streptococcus pneumoniae infection, acute pneumonia, otitis media and meningitis .
|
-
- HY-B1829A
-
|
Dexamethasone 21-phosphate disodium
|
Glucocorticoid Receptor
TGF-β Receptor
Interleukin Related
|
Neurological Disease
Inflammation/Immunology
|
|
Dexamethasone phosphate (Dexamethasone 21-phosphate) disodium is a prodrug form of the glucocorticoid Dexamethasone (HY-14648). Dexamethasone phosphate disodium is produced by introducing a phosphate ester group at the 21-position of the Dexamethasone molecule, forming a salt with sodium ions, thereby significantly improving water solubility. Dexamethasone phosphate disodium inhibits LPS (HY-D1056)-induced degradation of IRAK-1 and IRAK-4, and blocks LPS-induced activation of TRAF6, p-TAK1 and p-JNK. Dexamethasone phosphate disodium inhibits the secretion of RANTES, TGF-β1 and NO, promotes the production of MIP-1α and IL-10, and blocks microglial migration. Dexamethasone phosphate disodium is almost completely converted to Dexamethasone in rat blood, and supports transdermal delivery via iontophoresis. Dexamethasone phosphate disodium can be used in research related to steroid-dependent ulcerative colitis, chemotherapy-induced vomiting, allergic asthma and acute colitis (inflammatory bowel disease) .
|
-
- HY-W039897
-
|
α-Methyl-D-mannoside
|
Environmental Pollutants
Bacterial
|
Infection
|
|
Methyl α-D-mannopyranoside (α-Methyl-D-mannoside) is a methyl glycoside derivative and conformational stabilizer of α-D-mannopyranose. The glycosidic bond conformation of Methyl α-D-mannopyranoside is significantly affected by the environment. In aqueous solution, Methyl α-D-mannopyranoside stabilizes into a trans conformation via intermolecular hydrogen bonds; in the gas phase, however, steric interactions drive Methyl α-D-mannopyranoside to prefer a clockwise gauche conformation. Methyl α-D-mannopyranoside also serves as a major component of secondary cell wall polymers in some bacteria and an active precursor site for virus-targeted glycoproteins. Methyl α-D-mannopyranoside acts as an acceptor substrate for alternansucrase, mediating the transfer of D-glucopyranosyl groups to generate a variety of glycosylated oligosaccharide products, with methyl α-D-glucopyranosyl-(1→6)-α-D-mannopyranoside as the main component. Methyl α-D-mannopyranoside is applicable to studies on bacterial pathogenic mechanisms associated with mannose-specific fimbrial lectins .
|
-
- HY-B1829AR
-
|
Dexamethasone 21-phosphate disodium (Standard)
|
Glucocorticoid Receptor
Reference Standards
Interleukin Related
TGF-β Receptor
|
Neurological Disease
Metabolic Disease
Inflammation/Immunology
|
|
Dexamethasone phosphate (Dexamethasone 21-phosphate) disodium (Standard) is the analytical standard of Dexamethasone phosphate disodium (HY-B1829A). This product is intended for research and analytical applications. Dexamethasone phosphate (Dexamethasone 21-phosphate) disodium is a prodrug form of the glucocorticoid Dexamethasone (HY-14648). Dexamethasone phosphate disodium is produced by introducing a phosphate ester group at the 21-position of the Dexamethasone molecule, forming a salt with sodium ions, thereby significantly improving water solubility. Dexamethasone phosphate disodium inhibits LPS (HY-D1056)-induced degradation of IRAK-1 and IRAK-4, and blocks LPS-induced activation of TRAF6, p-TAK1 and p-JNK. Dexamethasone phosphate disodium inhibits the secretion of RANTES, TGF-β1 and NO, promotes the production of MIP-1α and IL-10, and blocks microglial migration. Dexamethasone phosphate disodium is almost completely converted to Dexamethasone in rat blood, and supports transdermal delivery via iontophoresis. Dexamethasone phosphate disodium can be used in research related to steroid-dependent ulcerative colitis, chemotherapy-induced vomiting, allergic asthma and acute colitis (inflammatory bowel disease).
|
-
-
-
HY-L042
-
|
|
894 compounds
|
|
Glycosides are compounds in which a sugar group is bonded through its anomeric carbon to another group via a glycosidic bond. Many biologically active compounds are glycosides. Glycosides comprise several important classes of compounds such as hormones, sweeteners, alkaloids, flavonoids, antibiotics, etc. The glycosidic residue can be crucial for their activity or can only improve pharmacokinetic parameters. Glycosides, which exhibit anti-inflammatory, anti-infection, anti-cancer and anti-oxidative properties, play numerous important roles in living organisms, such as streptomycin, as an aminoglycoside antibiotic, has anti-infection activity. Anthracyclines possess good antibacterial and anti-cancer activities.
MCE Glycoside Compound Library contains a unique collection of 894 glycoside compounds and is a useful tool to discovery glycoside drugs.
|
-
-
HY-L907
-
|
|
12,412 compounds
|
|
The most prominent mechanism of action of kinase inhibitors is their competition with ATP by binding to the hinge region of the kinase protein. Once the kinase is blocked by an inhibitor, it loses the ability to transfer phosphate groups from ATP to other molecules, resulting in the loss of kinase activity.
The hinge-binding region of kinase inhibitors mimics the interaction pattern between the ATP nucleobase and the kinase. MCE extracted thousands of kinase inhibitors from the ChEMBL database and isolated their molecular fragments. In certain cases, the amino and amide groups on the molecular fragments are crucial for binding in the hinge region. Therefore, we enhanced the diversity of the collected results by adding these two groups to unoccupied positions on the ring system. Subsequently, the fragments were assessed for their hinge region binding ability via docking at distinct kinases, we also applied pharmacophore constraints to ensure interactions with key amino acids in the kinase hinge region, ultimately obtaining kinase-related molecular fragments.
MCE provides over 12,412 kinase fragment molecules that meet the above requirements and are available off the shelf, serving as an effective tool for screening and developing drugs targeting kinases.
|
| Cat. No. |
Product Name |
Type |
-
- HY-D2381
-
|
|
Fluorescent Dyes
|
|
AF 488 maleimide is a thiol-reactive dye used to label SH groups of proteins, which can attach the AF 488 fluorophore to cysteine residue-containing proteins and peptides as well as other thiolated molecules. AF 488 maleimide enables real-time visualization of dynamic pilus extension and retraction in live bacterial cells via epifluorescence microscopy (Ex/Em = 470/520 nm) .
|
-
- HY-D1078
-
|
|
Fluorescent Dyes
|
|
5 (6)-Carboxy-2',7'-dichlorofluorescein diacetate is a fluorescein-based reactive oxygen species (ROS) probe and also a MRP2 substrate. 5 (6)-Carboxy-2',7'-dichlorofluorescein diacetate serves as a substrate for intracellular esterases, which cleave its acetate groups to generate a fluorescent product capable of detecting intracellular ROS. 5 (6)-Carboxy-2',7'-dichlorofluorescein diacetate is ATP-dependent and is transported via a single MRP2 binding site; it competes with LTC4 for MRP2 binding sites and inhibits MRP2-mediated LTC4 transport (Ex/Em = 496/525 nm) .
|
-
- HY-D1320
-
|
|
Fluorescent Dyes
|
|
Cyanine5 azide chloride is a potent fluorescent dye. Cyanine5 azide chloride can be reacted with terminal alkynes via a copper-catalyzed click reaction (CuAAC). (λex=646 nm, λem=662 nm) . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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-
- HY-114354
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BOD FL alkyne
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Fluorescent Dyes
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BODIPY (BOD) FL alkyne is an alkyne-containing BODIPY fluorophore derivative. BODIPY FL alkyne is a bioorthogonal labeling reagent with low toxicity and extremely low non-specific reactivity, and it is widely used in fluorescent bioimaging. BODIPY FL alkyne specifically labels azide groups on intracellular glycoconjugates mainly via strain-promoted azide-alkyne cycloaddition (SPAAC), or mediates site-specific conjugation with proteins such as IL-33, and supports positive cross-linking with other probes (e.g., DBCO-SCy5) for dual labeling. With the advantages of high specificity and low background interference, BODIPY FL alkyne can be used in the research of related diseases such as asthma, atopic dermatitis and inflammatory bowel disease .
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- HY-D1175
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Fluorescent Dyes
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Alizarin cyanin green F is an alizarin dye that reacts with calcium possibly via sulfonic acid and/or OH groups.
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- HY-D2167
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Fluorescent Dyes
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AF 568 alkyne is a derivative of the orange fluorescent dye AF 568. AF 568 has an absorption wavelength of 590-720 nm (FRET) and an emission wavelength of 515-720 nm. AF 568 alkyne can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) via the Alkyne group and molecules containing Azide groups. To achieve specific coupling of dye labels and biomolecules .
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- HY-D1993
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Fluorescent Dyes
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ATTO 647 NHS ester is a fluorescent label targeting free amino groups. ATTO 647 NHS ester can undergo a nucleophilic reaction with the free amino groups of EF-C peptide via its activated carboxylic acid group to form a stable covalent conjugate. ATTO 647 NHS ester-labeled nanofibers not only retain retroviral transduction-enhancing activity but also maintain stable fluorescent signals in both buffer and cell culture systems. ATTO 647 NHS ester is suitable for detection applications including fluorescence spectroscopy, microscopy and flow cytometry. ATTO 647 NHS ester has been used in studies related to HIV-1 infection .
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- HY-151704
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Fluorescent Dyes
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ICG-alkyne is a short-wave infrared (SWIR)-emitting cyanine fluorescent probe based on alkyne-derivatized indocyanine green. ICG-alkyne can undergo click chemistry reaction to conjugate with antibody molecules via binding to the azide groups introduced into antibodies. ICG-alkyne enables SWIR fluorescent molecular imaging of breast tumors in living mice. ICG-alkyne can be used in breast cancer-related research .
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- HY-D2748
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Fluorescent Dyes
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5-JOE azide is a fluorescent dye with the emission in yellow region of the spectrum. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.
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- HY-D2164
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Fluorescent Dyes
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AF 430 alkyne is a derivative of the yellow fluorescent dye AF 430. AF430 has an excitation wavelength of 425 nm and an emission wavelength of 542 nm. AF 430 alkyne can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) via Alkyne groups and molecules containing Azide groups. To achieve specific coupling of dye labels and biomolecules .
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- HY-135414A
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Fluorescent Dyes
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Cyanine5 NHS ester bromide is a active compound, can be used to label amino groups in peptides, proteins, and oligonucleotides. Cyanine5 NHS ester bromide is a cyanine dye, fluorescence-labeling neurotensin (8-13) via arginine residues .
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- HY-W800808
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Fluorescent Dyes
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ROX azide, 5-isomer is a red-emitting rhodamine dye possessing high brightness and fluorescence quantum yield. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.
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- HY-D2151
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Fluorescent Dyes
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AF 430 hydrazide is a derivative of the yellow fluorescent dye AF 430. AF430 has an excitation wavelength of 425 nm and an emission wavelength of 542 nm. AF 430 hydrazide can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) via the Azide group and molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups. To achieve specific coupling of dye labels and biomolecules .
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- HY-D2156
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Fluorescent Dyes
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AF 430 azide is a derivative of the yellow fluorescent dye AF 430. AF430 has an excitation wavelength of 425 nm and an emission wavelength of 542 nm. AF 430 azide can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) via the azide group and molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. To achieve specific coupling of dye labels and biomolecules .
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- HY-D2168
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Fluorescent Dyes
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AF 568 azide is an azide derivative of the orange fluorescent dye AF 568. AF 568 has an absorption wavelength of 590-720 nm (FRET) and an emission wavelength of 515-720 nm. AF 568 alkyne can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) via the Azide group and molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups. To achieve specific coupling of dye labels and biomolecules .
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- HY-W800775
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Fluorescent Dyes
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BP Fluor 647 Alkyne is a bright green-fluorescent dye optimal for use with the 633, 650 nm Argon laser. The alkyne group can react with azides via copper catalyzed Click Chemistry reactions. The dye is water soluble and pH-insensitive from pH 4 to pH 10. The dye has 4 sulfonate groups which make it highly water soluble and cause less aggregation in the aqueous solution. BP Fluor 647 Alkyne is used for protein and antibody labeling, or nucleic acid applications with high labeling density.
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- HY-D2165
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Fluorescent Dyes
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AF 594 streptavidin is a bioconjugating agent. It consists of AF 594 and streptomycin, a streptomycin derivative of the red fluorescent dye AF 594. AF 594 has high fluorescence quantum yield and high photostability (Ex=594 nm, Em=615 nm). AF 594 streptavidin can be selectively conjugated to streptavidin-modified molecules via a streptomycin-modifying group for fluorescent labeling and spectroscopic analysis .
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- HY-W840196
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Fluorescent Dyes
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Hex-5-ynehydrazide is a bifunctional linker reagent with a terminal hydrazide group and a propargyl group. The hydrazide group can react with an aldehyde to form a semi-permanent hydrozone bond. The propargyl group can be linked to azide-containing biomolecules via Click Chemistry.
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- HY-W800807
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Fluorescent Dyes
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R6G azide, 5-isomer is a xanthene dye with a terminal azide. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.
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-
- HY-D3325
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Fluorescent Dyes
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AF 700 NHS ester is a fluorescent dye AF 700 derivative exhibits high fluorescence quantum yield and high photostability. AF 700 NHS ester can form an ester bond with ammonia via the NHS group, and can be used to label proteins, amine-modified oligonucleotides, and other primary amines (R-NH2) containing amine molecules (Ex/Em = 702/723 nm).
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- HY-D3257
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Fluorescent Dyes
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AF 546 NHS ester is a fluorescent dye AF 546 derivative exhibits high fluorescence quantum yield and high photostability. AF 546 NHS ester can form an ester bond with ammonia via the NHS group, and can be used to label proteins, amine-modified oligonucleotides, and other primary amines (R-NH2) containing amine molecules (Ex/Em = 554/570 nm).
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- HY-D3259
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Fluorescent Dyes
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AF 680 NHS ester is a fluorescent dye AF 680 derivative exhibits high fluorescence quantum yield and high photostability. AF 680 NHS ester can form an ester bond with ammonia via the NHS group, and can be used to label proteins, amine-modified oligonucleotides, and other primary amines (R-NH2) containing amine molecules (Ex/Em = 684/707 nm).
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- HY-D3326
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Fluorescent Dyes
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AF 750 NHS ester is a fluorescent dye AF 750 derivative exhibits high fluorescence quantum yield and high photostability. AF 750 NHS ester can form an ester bond with ammonia via the NHS group, and can be used to label proteins, amine-modified oligonucleotides, and other primary amines (R-NH2) containing amine molecules (Ex/Em = 753/782 nm).
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- HY-D3323
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Fluorescent Dyes
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AF 350 NHS ester is a fluorescent dye AF 350 derivative exhibits high fluorescence quantum yield and high photostability. AF 350 NHS ester can form an ester bond with ammonia via the NHS group, and can be used to label proteins, amine-modified oligonucleotides, and other primary amines (R-NH2) containing amine molecules (Ex/Em = 346/445 nm) .
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- HY-D3258
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Fluorescent Dyes
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AF 660 NHS ester is a fluorescent dye AF 660 derivative exhibits high fluorescence quantum yield and high photostability. AF 660 NHS ester can form an ester bond with ammonia via the NHS group, and can be used to label proteins, amine-modified oligonucleotides, and other primary amines (R-NH2) containing amine molecules (Ex/Em = 668/698 nm).
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- HY-D3256
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Fluorescent Dyes
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AF 532 NHS ester is a fluorescent dye AF 532 derivative exhibits high fluorescence quantum yield and high photostability. AF 532 NHS ester can form an ester bond with ammonia via the NHS group, and can be used to label proteins, amine-modified oligonucleotides, and other primary amines (R-NH2) containing amine molecules (Ex/Em = 530/555 nm).
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- HY-D3277
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Fluorescent Dyes
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PE-VF594 is a high-brightness fluorescent dye used in flow cytometry, primarily for labeling antibodies or streptavidin to help identify specific cell subpopulations. PE-VF594 is a tandem dye composed of two covalently linked fluorescent groups: one is phycoerythrin (PE), responsible for absorbing laser energy; the other is the receptor molecule VF594. Energy is transferred from PE to VF594 via fluorescence resonance energy transfer (FRET) mechanism (Ex/Em = 450-500 nm/614 nm) .
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- HY-D3210
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Fluorescent Dyes
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DCM-KPV is a fluorescent probe targeting the human intestinal oligopeptide transporter PEPT1/SLC15A1 receptor (λex=480 nm, λem=620-670 nm). DCM-KPV specifically binds to PepT1 via its KPV domain and mediates receptor-targeted internalization, thus effectively accumulating in the cytoplasm and nucleus of cells overexpressing this receptor. DCM-KPV has the advantages of long emission wavelength, high emission efficiency, low photobleaching, and negligible cytotoxicity. DCM-KPV maintains stable fluorescence intensity under continuous illumination, exhibiting extremely high live cell compatibility. DCM-KPV can specifically accumulate at colonic inflammatory sites through the intestinal mucosa, enabling direct non-invasive visual differentiation between chronic and acute ulcerative colitis groups and the normal group .
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- HY-D3181
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Fluorescent Dyes
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CyGbPF is a granzyme B-specific near-infrared fluorescent probe. CyGbPF can be cleaved by granzyme B to remove the peptide cage group, restoring near-infrared fluorescence. CyGbPF passively accumulates in mouse tumors, and its activated fluorescence correlates with granzyme B expression, CD8 + cytotoxic T lymphocyte populations, and CD4 + helper T lymphocyte populations in tumor tissues. CyGbPF is efficiently cleared by the kidneys, enabling the assessment of immune activation via optical urine analysis. CyGbPF allows real-time non-invasive evaluation of cancer immunotherapeutic efficacy in living animals. CyGbPF can be used in research on cancers such as breast cancer. Excitation wavelength/emission wavelength: approximately 658 nm/approximately 717 nm .
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| Cat. No. |
Product Name |
Type |
-
- HY-129832
-
Biotin-azide
Maximum Cited Publications
8 Publications Verification
N-(3-Azidopropyl)biotinamide
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Biochemical Assay Reagents
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Biotin-azide (N-(3-Azidopropyl)biotinamide) is a form of biotin with a terminal azide group. Biotin-azide can be used to prepare various biotinylated conjugates via Click Chemistry . Biotin-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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-
- HY-W020780
-
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mPEG5000-Maleimide
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Biochemical Assay Reagents
|
|
mPEG5000-Mal (mPEG5000-Maleimide) is a PEG-derived selective covalent binding agent for sulfhydryl groups (RSGs), which can form irreversible thioether bonds with sulfhydryl groups under near-neutral conditions via the maleimide group. The mechanism of action of mPEG5000-Mal can be divided into two categories: firstly, as an enzyme modifier, it binds to target proteins through hydrophobic interactions, hydrogen bonds, and van der Waals forces, altering the protein's secondary structure; secondly, as a nanoparticle surface modifier, it covalently binds to sulfhydryl groups on the surface of red blood cells, changing the surface properties and morphology of the red blood cells, leading to their phagocytosis by macrophages of the reticuloendothelial system. mPEG5000-Mal can react with free cysteine in proteins, increasing the apparent molecular weight of the modified protein by 10-15 kDa for detection purposes. mPEG5000-Mal can enhance the thermal stability and catalytic activity of enzymes, and improve the macrophage targeting of nanoparticles, enabling targeted drug delivery. mPEG5000-Mal can be applied in enzyme engineering research in the food industry and in oncology, assisting radiotherapy by inhibiting tumor-associated macrophage infiltration and enhancing anti-tumor immune responses .
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- HY-W068119A
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2-Maleimidoethylamine hydrochloride
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Biochemical Assay Reagents
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|
N-(2-Aminoethyl)maleimide (2-Maleimidoethylamine) hydrochloride is a selective covalent binding agent for thiol groups (RSGs), covalently binding to thiols via an irreversible thioether bond to prepare MMP-2-sensitive nanosystems. Under near-neutral conditions, the maleimide group in N-(2-Aminoethyl)maleimide hydrochloride binds to thiol groups via a nucleophilic addition reaction, and can be used to modify polymers or biological interfaces, enhancing mucosal adhesion and regulating the surface charge of biological interfaces. N-(2-Aminoethyl)maleimide hydrochloride can optimize the adhesion performance of drug delivery carriers and cell interactions with biological interfaces, and is applied in transmucosal drug delivery systems (such as drug carriers for oral and bladder sites) and biomaterial surface engineering research, providing support for tissue implantation, regeneration, and related drug delivery .
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- HY-W440896
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Biochemical Assay Reagents
|
|
DSPE-PEG2000-SH is an amphiphilic thiol-functionalized DSPE-PEG molecule. DSPE-PEG2000-SH inserts into extracellular vesicle (EV) bilayer membranes via hydrophobic interactions, displaying surface thiol groups to form EV-SH crosslinkers.DSPE-PEG2000-SH enables crosslinking of EV-SH with 8-arm PEG-norbornene via thiol-ene photochemistry to construct hydrogels, with hydrogel mechanical properties tunable via PEG segment molecular weight variation.DSPE-PEG2000-SH can be used to encapsulate agents for drug delivery system, such as mRNA vaccine .
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- HY-149449
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Biochemical Assay Reagents
|
|
Poly-L-γ-glutamic acid sodium is a macromolecular polymer formed by the linkage of glutamic acid residues via peptide bonds between γ-amino and carboxyl groups. Poly-L-γ-glutamic acid sodium plays an important role as a carrier material in compound delivery systems. Poly-L-γ-glutamic acid sodium can deliver Paclitaxel (HY-B0015) to colon cancer cells, reduce cell viability and inhibit the growth of colon cancer spheroids. Poly-L-γ-glutamic acid sodium can be used as a carrier material and in studies related to colon cancer in mice .
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- HY-168940B
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Biochemical Assay Reagents
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|
NH2-PEG2000-COOH is a heterofunctional polyethylene glycol with one amino terminal group and one carboxyl terminal group. NH2-PEG2000-COOH reacts with N-succinimidyl-6-maleimidohexanoate to introduce a maleimide terminal group, followed by conjugation with thiolated RGD peptide via a thiol-maleimide coupling reaction to synthesize RGD-PEG-COOH. NH2-PEG2000-COOH can be used in cancer research .
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-
- HY-W1048558A
-
|
mPEG2000-COOH
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Biochemical Assay Reagents
|
|
mPEG2000-CM (mPEG2000-COOH) is a carboxyl-terminated monomethoxy polyethylene glycol. mPEG2000-CM bears a reactive carboxyl group (-COOH) at its structural terminal site, which can form stable amide bonds with amino groups and ester bonds with hydroxyl groups. mPEG2000-CM binds to PCA-g-PCL copolymers via electrostatic interaction to form polyion complex micelles with a hydrophilic PEG surface, which enhances the stability of micelles in aqueous media. mPEG2000-CM can be used for drug delivery .
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-
- HY-P2975
-
|
Mouse laminin (Engelbreth-Holm-Swarm murine sarcoma basement membrane)
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Biochemical Assay Reagents
|
|
Laminin (Engelbreth-Holm-Swarm murine sarcoma basement membrane) is a crucial structural element in animal tissues, forming part of the scaffolding that supports tissue architecture. It interacts with type IV collagen through entactin and perlecan, connects to cell membranes via integrin receptors, dystroglycan complexes, and Lutheran blood group glycoproteins, and contains functional domains that facilitate collagen binding, cell adhesion, heparin interaction, and promote neurite outgrowth.
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-
- HY-D0874
-
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|
Biochemical Assay Reagents
|
|
HEPPSO is a zwitterionic Good's buffer suitable for physiological pH conditions. HEPPSO forms high-order oligomers in aqueous solutions and can form a 1:1 complex with Cu 2+ via its hydroxyalkyl and tertiary amine groups. However, HEPPSO contains a structurally similar trace impurity lacking an alkanesulfonic acid side chain. The complex formed by this impurity and Cu 2+ has a very low Ka; therefore, HEPPSO may interfere with studies on copper speciation analysis in natural water bodies .
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-
- HY-D1078
-
|
|
Biochemical Assay Reagents
|
|
5 (6)-Carboxy-2',7'-dichlorofluorescein diacetate is a fluorescein-based reactive oxygen species (ROS) probe and also a MRP2 substrate. 5 (6)-Carboxy-2',7'-dichlorofluorescein diacetate serves as a substrate for intracellular esterases, which cleave its acetate groups to generate a fluorescent product capable of detecting intracellular ROS. 5 (6)-Carboxy-2',7'-dichlorofluorescein diacetate is ATP-dependent and is transported via a single MRP2 binding site; it competes with LTC4 for MRP2 binding sites and inhibits MRP2-mediated LTC4 transport (Ex/Em = 496/525 nm) .
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-
- HY-76440
-
|
Oxetan-3-one
|
Biochemical Assay Reagents
|
|
3-Oxetanone (Oxetan-3-one) is a four-membered cyclic ketone and strained cyclic ether derivative with measurable molecular g-value, magnetic susceptibility anisotropy and molecular quadrupole moment. 3-Oxetanone acts not only as a hydrogen bond acceptor, a tetrel donor and a weak hydrogen bond acceptor, but also forms a classic O-H···O hydrogen bond with H2O via the ether oxygen atom. Alternatively, it forms a C···O tetrel bond with formaldehyde using its carbonyl group as a tetrel donor, while acting as a proton acceptor to form a C-H···O weak hydrogen bond with formaldehyde. 3-Oxetanone can be used to prepare various oxetanes .
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-
- HY-140678
-
|
mPEG10000-NH2
|
Biochemical Assay Reagents
|
|
DBCO-PEG10000-Amine (DBCO-PEG10000-NH2) is a polyethylene glycol derivative containing dibenzocyclooctyne. DBCO-PEG-Amine is a universal, modular "bridge molecule": it forms stable covalent linkage with target materials (e.g., MSN or polymers) via the amino group at one end, while the DBCO group at the other end enables efficient, specific, and biocompatible click chemical conjugation with any azide-bearing biological entities (e.g., bacteria, cells) in subsequent steps .
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-
- HY-W017425
-
|
Phenylhydrazine acetate
|
Biochemical Assay Reagents
|
|
N'-Phenylacetohydrazide consists of a phenyl group attached to the acetylhydrazide functional group via a hydrazine bond. This compound is commonly used as a reagent in organic chemistry for the determination of carbonyl compounds such as aldehydes and ketones.
|
-
- HY-W012206
-
|
|
Biochemical Assay Reagents
|
|
(Rac)-Metanephrine hydrochloride is a metabolite of epinephrine and a substrate of the sulfotransferase SULT1A3. (Rac)-Metanephrine hydrochloride undergoes sulfonation at its p-hydroxyl group via a reaction catalyzed by SULT1A3. (Rac)-Metanephrine hydrochloride is an isomer of Metanephrine (HY-113299) hydrochloride, and it is applicable to the research of pheochromocytoma .
|
-
- HY-174935
-
|
|
Biochemical Assay Reagents
|
|
DBCO-PEG1000-NHS is a dibenzocyclooctyne-conjugated polyethylene glycol derivative bearing an NHS group. DBCO-PEG-NHS forms a stable covalent linkage with the amino group of target molecules via the NHS ester at one end, while introducing a DBCO group at the other end, thus preparing for subsequent click chemical conjugation with any azide-bearing molecule or material .
|
-
- HY-174935A
-
|
|
Biochemical Assay Reagents
|
|
DBCO-PEG2000-NHS is a dibenzocyclooctyne-conjugated polyethylene glycol derivative bearing an NHS group. DBCO-PEG-NHS forms a stable covalent linkage with the amino group of target molecules via the NHS ester at one end, while introducing a DBCO group at the other end, thus preparing for subsequent click chemical conjugation with any azide-bearing molecule or material .
|
-
- HY-174929A
-
|
DBCO-PEG5000-NH2
|
Biochemical Assay Reagents
|
|
DBCO-PEG5000-Amine (DBCO-PEG5000-NH2) is a polyethylene glycol derivative containing dibenzocyclooctyne. DBCO-PEG-Amine is a universal, modular "bridge molecule": it forms stable covalent linkage with target materials (e.g., MSN or polymers) via the amino group at one end, while the DBCO group at the other end enables efficient, specific, and biocompatible click chemical conjugation with any azide-bearing biological entities (e.g., bacteria, cells) in subsequent steps .
|
-
- HY-W1048851B
-
|
4-Arm-PEG10000-Mal
|
Biochemical Assay Reagents
|
|
4-Arm-PEG10000-Maleimide (4-Arm-PEG10000-Mal) is a four-arm star-shaped multifunctional PEG crosslinker with an average molecular weight of 10 kDa and maleimide terminal groups. 4-Arm-PEG10000-Maleimide efficiently conjugates biomolecules via thiol-Michael reaction, and is widely used in protein modification, antibody-drug conjugation and biomaterial preparation .
|
-
- HY-Y0425
-
|
|
Biochemical Assay Reagents
|
|
Terephthalaldehyde is a crosslinking agent. Terephthalaldehyde forms a crosslinked structure inside the gelatin matrix by forming Schiff base imines with the amino groups of gelatin, thereby constructing a three-dimensional network. Terephthalaldehyde improves the hydrophobicity of the gelatin matrix, delays water vapor penetration and enhances the liquid water resistance of gelatin films. Terephthalaldehyde can be used as a crosslinking agent to prepare crosslinked chitosan hydrogel (CAAT) via ultrasound-induced synthesis. Terephthalaldehyde helps CAAT hydrogels selectively adsorb anionic dyes from aqueous media, including multi-component systems containing cationic dyes. Terephthalaldehyde serves as a starting material for the synthesis of bis-heterocyclic compounds (including bis-thiazole and bis-triazolopyrimidine compounds) .
|
-
- HY-174935C
-
|
|
Biochemical Assay Reagents
|
|
DBCO-PEG5000-NHS is a dibenzocyclooctyne-conjugated polyethylene glycol derivative bearing an NHS group. DBCO-PEG-NHS forms a stable covalent linkage with the amino group of target molecules via the NHS ester at one end, while introducing a DBCO group at the other end, thus preparing for subsequent click chemical conjugation with any azide-bearing molecule or material .
|
-
- HY-34502
-
|
6-Indolecarbonitrile
|
Biochemical Assay Reagents
|
|
6-Cyanoindole is a biochemical reagent that can be used as a biological material or organic compound for life science related research. 6-Cyanoindole is a significant indole derivative for the electron-withdrawing -C≡N group. 6-Cyanoindole can be used to generate a copolymer P(6CNIn-co-EDOT) via electrocopolymerization with EDOT .
|
-
- HY-174929
-
|
DBCO-PEG3400-NH2
|
Biochemical Assay Reagents
|
|
DBCO-PEG3400-Amine (DBCO-PEG3400-NH2) is a polyethylene glycol derivative containing dibenzocyclooctyne. DBCO-PEG-Amine is a universal, modular "bridge molecule": it forms stable covalent linkage with target materials (e.g., MSN or polymers) via the amino group at one end, while the DBCO group at the other end enables efficient, specific, and biocompatible click chemical conjugation with any azide-bearing biological entities (e.g., bacteria, cells) in subsequent steps .
|
-
- HY-174935B
-
|
|
Biochemical Assay Reagents
|
|
DBCO-PEG3400-NHS is a dibenzocyclooctyne-conjugated polyethylene glycol derivative bearing an NHS group. DBCO-PEG-NHS forms a stable covalent linkage with the amino group of target molecules via the NHS ester at one end, while introducing a DBCO group at the other end, thus preparing for subsequent click chemical conjugation with any azide-bearing molecule or material .
|
-
- HY-174935D
-
|
|
Biochemical Assay Reagents
|
|
DBCO-PEG10000-NHS is a dibenzocyclooctyne-conjugated polyethylene glycol derivative bearing an NHS group. DBCO-PEG-NHS forms a stable covalent linkage with the amino group of target molecules via the NHS ester at one end, while introducing a DBCO group at the other end, thus preparing for subsequent click chemical conjugation with any azide-bearing molecule or material .
|
-
- HY-140895B
-
|
Biotin-PEG10000-NH2
|
Biochemical Assay Reagents
|
|
Biotin-PEG10000-Amine (Biotin-PEG10000-NH2) is a biotin PEG polymer containing a free amine group (-NH2). The amine group is reactive with an activated NHS ester via formation of an amide bond. Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection .
|
-
- HY-140895D
-
|
Biotin-PEG40000-NH2
|
Biochemical Assay Reagents
|
|
Biotin-PEG40000-Amine (Biotin-PEG40000-NH2) is a biotin PEG polymer containing a free amine group (-NH2). The amine group is reactive with an activated NHS ester via formation of an amide bond. Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection .
|
-
- HY-140895C
-
|
Biotin-PEG20000-NH2
|
Biochemical Assay Reagents
|
|
Biotin-PEG20000-Amine (Biotin-PEG20000-NH2) is a biotin PEG polymer containing a free amine group (-NH2). The amine group is reactive with an activated NHS ester via formation of an amide bond. Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection .
|
-
- HY-172270D
-
|
|
Biochemical Assay Reagents
|
|
DSPE-PEG1000-PTP is synthesised by conjugating the amino group of plectin-1 peptide (PTP) with DSPE-PEG-NHS ester via amide bonds. DSPE-PEG1000-PTP can be used to construct drug delivery vectors .
|
-
- HY-172270
-
|
|
Biochemical Assay Reagents
|
|
DSPE-PEG1000-PTP is synthesised by conjugating the amino group of plectin-1 peptide (PTP) with DSPE-PEG-NHS ester via amide bonds. DSPE-PEG1000-PTP can be used to construct drug delivery vectors .
|
-
- HY-172270A
-
|
|
Biochemical Assay Reagents
|
|
DSPE-PEG1000-PTP is synthesised by conjugating the amino group of plectin-1 peptide (PTP) with DSPE-PEG-NHS ester via amide bonds. DSPE-PEG1000-PTP can be used to construct drug delivery vectors .
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-
- HY-W075836
-
|
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Biochemical Assay Reagents
|
|
Ferrocenylmethyltrimethylammonium (iodide) is an organometallic salt consisting of a ferrocenyl group attached to a quaternary ammonium cation via a methylene bridge. Ferrocenylmethyltrimethylammonium (iodide) has been used as a catalyst and reagent in various organic reactions, including oxidation, reduction, and CH bond activation. In addition, it is also used as a precursor for the synthesis of other organometallic compounds and as a potential material for electrochemical applications.
|
-
- HY-200288B
-
|
|
Biochemical Assay Reagents
|
|
DMG-PEG3400-COOH is a conjugate composed of DMG, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DMG-PEG3400-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.
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-
- HY-W1052117A
-
|
|
Biochemical Assay Reagents
|
|
DMPE-PEG3400-COOH is a conjugate composed of DMPE, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DMPE-PEG3400-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.
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-
- HY-W1052873C
-
|
|
Biochemical Assay Reagents
|
|
DPPE-PEG1000-COOH is a conjugate composed of DPPE, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DPPE-PEG1000-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.
|
-
- HY-W1052117
-
|
|
Biochemical Assay Reagents
|
|
DMPE-PEG2000-COOH is a conjugate composed of DMPE, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DMPE-PEG2000-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.
|
-
- HY-183173B
-
|
|
Biochemical Assay Reagents
|
|
DSG-PEG3400-COOH is a conjugate composed of DSG, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DSG-PEG3400-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.
|
-
- HY-183173
-
|
|
Biochemical Assay Reagents
|
|
DSG-PEG1000-COOH is a conjugate composed of DSG, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DSG-PEG1000-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.
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-
- HY-W1052873D
-
|
|
Biochemical Assay Reagents
|
|
DPPE-PEG10000-COOH is a conjugate composed of DPPE, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DPPE-PEG10000-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.
|
-
- HY-200288
-
|
|
Biochemical Assay Reagents
|
|
DMG-PEG2000-COOH is a conjugate composed of DMG, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DMG-PEG2000-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.
|
-
- HY-183173A
-
|
|
Biochemical Assay Reagents
|
|
DSG-PEG2000-COOH is a conjugate composed of DSG, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DSG-PEG2000-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.
|
-
- HY-200288A
-
|
|
Biochemical Assay Reagents
|
|
DMG-PEG1000-COOH is a conjugate composed of DMG, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DMG-PEG1000-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.
|
-
- HY-W1052873
-
|
|
Biochemical Assay Reagents
|
|
DPPE-PEG2000-COOH is a conjugate composed of DPPE, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DPPE-PEG2000-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.
|
-
- HY-W1052117D
-
|
|
Biochemical Assay Reagents
|
|
DMPE-PEG1000-COOH is a conjugate composed of DMPE, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DMPE-PEG1000-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.
|
-
- HY-183173D
-
|
|
Biochemical Assay Reagents
|
|
DSG-PEG10000-COOH is a conjugate composed of DSG, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DSG-PEG10000-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.
|
-
- HY-200288D
-
|
|
Biochemical Assay Reagents
|
|
DMG-PEG10000-COOH is a conjugate composed of DMG, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DMG-PEG10000-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.
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-
- HY-W1052873B
-
|
|
Biochemical Assay Reagents
|
|
DPPE-PEG5000-COOH is a conjugate composed of DPPE, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DPPE-PEG5000-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.
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-
- HY-W1052873A
-
|
|
Biochemical Assay Reagents
|
|
DPPE-PEG3400-COOH is a conjugate composed of DPPE, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DPPE-PEG3400-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.
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-
- HY-W1052117C
-
|
|
Biochemical Assay Reagents
|
|
DMPE-PEG1000-COOH is a conjugate composed of DMPE, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DMPE-PEG1000-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.
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-
- HY-183173C
-
|
|
Biochemical Assay Reagents
|
|
DSG-PEG5000-COOH is a conjugate composed of DSG, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DSG-PEG5000-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.
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-
- HY-200288C
-
|
|
Biochemical Assay Reagents
|
|
DMG-PEG5000-COOH is a conjugate composed of DMG, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DMG-PEG5000-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.
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- HY-W1052117B
-
|
|
Biochemical Assay Reagents
|
|
DMPE-PEG5000-COOH is a conjugate composed of DMPE, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DMPE-PEG5000-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.
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- HY-140895A
-
|
Biotin-PEG5000-NH2
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Biochemical Assay Reagents
|
|
Biotin-PEG5000-Amine (Biotin-PEG5000-NH2) is a biotin PEG polymer containing a free amine group (-NH2). The amine group is reactive with an activated NHS ester via formation of an amide bond. Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection .
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- HY-183168B
-
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Biochemical Assay Reagents
|
|
C18-PEG5000-COOH is a conjugate composed of an octadecyl group (C18 aliphatic chain), a PEG chain, and a carboxyl group (-COOH). C18-PEG5000-COOH combines the membrane compatibility of lipids with the carboxyl group, which can form amide bonds with primary amines via EDC/NHS activation, making it suitable for research in biomaterial construction and drug delivery.
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- HY-183168A
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Biochemical Assay Reagents
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C18-PEG3400-COOH is a conjugate composed of an octadecyl group (C18 aliphatic chain), a PEG chain, and a carboxyl group (-COOH). C18-PEG3400-COOH combines the membrane compatibility of lipids with the carboxyl group, which can form amide bonds with primary amines via EDC/NHS activation, making it suitable for research in biomaterial construction and drug delivery.
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- HY-183168
-
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Biochemical Assay Reagents
|
|
C18-PEG2000-COOH is a conjugate composed of an octadecyl group (C18 aliphatic chain), a PEG chain, and a carboxyl group (-COOH). C18-PEG2000-COOH combines the membrane compatibility of lipids with the carboxyl group, which can form amide bonds with primary amines via EDC/NHS activation, making it suitable for research in biomaterial construction and drug delivery.
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- HY-W1048860B
-
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Biochemical Assay Reagents
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4-Arm PEG10000-alkyne is a multi-arm PEG derivative with alkynyl groups at each end of four arms attached to a pentaerythritol core. PEG alkyne can be used for PEGylation via copper-catalyzed click chemistry with azides .
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- HY-W1048860D
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Biochemical Assay Reagents
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|
4-Arm PEG40000-alkyne is a multi-arm PEG derivative with alkynyl groups at each end of four arms attached to a pentaerythritol core. PEG alkyne can be used for PEGylation via copper-catalyzed click chemistry with azides .
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- HY-W1048860A
-
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|
Biochemical Assay Reagents
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|
4-Arm PEG5000-alkyne is a multi-arm PEG derivative with alkynyl groups at each end of four arms attached to a pentaerythritol core. PEG alkyne can be used for PEGylation via copper-catalyzed click chemistry with azides .
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- HY-W1048860C
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Biochemical Assay Reagents
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|
4-Arm PEG20000-alkyne is a multi-arm PEG derivative with alkynyl groups at each end of four arms attached to a pentaerythritol core. PEG alkyne can be used for PEGylation via copper-catalyzed click chemistry with azides .
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- HY-172270C
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Biochemical Assay Reagents
|
|
DSPE-PEG1000-PTP is synthesised by conjugating the amino group of plectin-1 peptide (PTP) with DSPE-PEG-NHS ester via amide bonds. DSPE-PEG1000-PTP can be used to construct drug delivery vectors .
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- HY-183133B
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Biochemical Assay Reagents
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|
C16-PEG5000-COOH is a conjugate composed of a hexadecyl (C16 aliphatic chain), a PEG chain, and a carboxyl group (-COOH). C16-PEG5000-COOH combines the membrane compatibility of lipids with the carboxyl group, which can form amide bonds with primary amines via EDC/NHS activation, making it suitable for research in biomaterial construction and drug delivery.
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- HY-183133
-
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Biochemical Assay Reagents
|
|
C16-PEG2000-COOH is a conjugate composed of a hexadecyl (C16 aliphatic chain), a PEG chain, and a carboxyl group (-COOH). C16-PEG2000-COOH combines the membrane compatibility of lipids with the carboxyl group, which can form amide bonds with primary amines via EDC/NHS activation, making it suitable for research in biomaterial construction and drug delivery.
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- HY-183133A
-
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|
Biochemical Assay Reagents
|
|
C16-PEG3400-COOH is a conjugate composed of a hexadecyl (C16 aliphatic chain), a PEG chain, and a carboxyl group (-COOH). C16-PEG3400-COOH combines the membrane compatibility of lipids with the carboxyl group, which can form amide bonds with primary amines via EDC/NHS activation, making it suitable for research in biomaterial construction and drug delivery.
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| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P4094
-
CTP
2 Publications Verification
Cardiac targeting peptide
|
Peptides
|
Cardiovascular Disease
|
|
CTP (cardiac targeting peptide) can transduce cardiomyocytes in vitro. CTP leads to efficient and specific transduction of heart tissue in mice model. CTP can be reversibly linked (e.g. via enolases, thiol groups) to cargo (e.g. miRNAs) for delivery specifically to cardiomyocytes over all other organs .
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-
- HY-148835
-
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Fluorescent Dye
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Others
|
|
AzGGK is an unnatural amino acid. AzGGK is site-specifically incorporated into proteins via genetic-code expansion. AzGGK can be used as site-specific probe for ubiquitylation and SUMOylation . AzGGK is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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-
- HY-P10646
-
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|
Biochemical Assay Reagents
|
Neurological Disease
|
|
Muscle homing peptide M12 can preferentially bind to surface protein of muscle cells. Muscle homing peptide M12 mediates enhanced cellular uptake of nanoparticles (NPs) in myoblasts in vitro. Muscle homing peptide M12 is covalently conjugated to PLGA-PEG NPs via the N-terminal α-amino groups of peptides using the N-hydroxysuccinimide ester reaction .
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-
- HY-P5057B
-
|
|
Fluorescent Dye
Bacterial
|
Infection
|
|
5-FAM-Ahx-LL-37 TFA is a 5-FAM (HY-66022) labeled LL-37, human (HY-P1222). The carboxyfluorescein group is attached via a 6-carbon spacer, 6-Aminohexanoic acid (Ahx, HY-B0236). LL-37, human is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity .
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-
- HY-148835A
-
|
|
Fluorescent Dye
|
Others
|
|
AzGGK TFA is an unnatural amino acid. AzGGK TFA is site-specifically incorporated into proteins via genetic-code expansion. AzGGK TFA can be used as a site-specific probe for ubiquitylation and SUMOylation. AzGGK TFA is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups .
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-
- HY-P0132A
-
|
|
NO Synthase
|
Cancer
|
|
YIGSR-Lys(N3) is a peptide that can inhibit the tumour growth and metastasis of leukaemic cells. YIGSR blocks the cellular binding to laminin I via a 67-kDa laminin-binding protein, and inhibits shear-induced increase in eNOS expression of laminin cells . YIGSR-Lys(N3) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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-
- HY-P11781A
-
|
|
Drug Derivative
|
Cancer
|
|
Cys-HW12 is a random peptide containing an N-terminal cysteine. Cys-HW12 can be coupled via the thiol group of Cys. Cys-HW12 can serve as a control for GE11 (HY-P10128)-conjugated mixed micelles targeting EGFR, and also functions as a cytotoxic agent, cellular uptake inhibitor, and tumor growth inhibitor. Cys-HW12 is applicable to pancreatic cancer-related research .
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-
- HY-P11772
-
|
|
Bacterial
|
Infection
|
|
LBP-14, a peptide, is a synthetic fragment of the LPS (HY-D1056) binding protein (LBP) and is a LPS antagonist. LBP-14 interacts with LPS via electrostatic contacts between arginine/lysine residues and LPS phosphate groups, and hydrophobic contacts between aromatic/aliphatic residues and LPS acyl chains, blocking LPS binding to LBP. LBP-14 moderately inhibits LPS-induced TNF-α formation. LBP-14 can be used for the research of gram-negative sepsis .
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
-
- HY-N3018
-
-
-
- HY-N0327
-
-
-
- HY-134222A
-
|
N-Acetyl-L-serine
|
Structural Classification
Natural Products
Classification of Application Fields
Other Diseases
Endogenous metabolite
Disease Research Fields
Source Classification
|
Endogenous Metabolite
Complement System
|
|
N-Acetylserine (N-Acetyl-L-serine) is a complement pathway modulator targeting activated third complement protein (C3b) and an amino-terminal residue (an N-terminal acetylation modification group). N-Acetylserine reacts with the exposed thioester group of C3b via its hydroxyl group, thereby blocking the covalent binding of glycerol to this thioester group. N-Acetylserine widely exists in soluble proteins of mammalian cells (accounting for approximately 80% of such proteins). N-Acetylserine has a blocking property that prevents direct Edman sequencing of proteins; deblocking is achievable through trifluoroacetic acid-catalyzed N→O acetyl migration followed by β-elimination. N-Acetylserine is suitable for sequencing of proteins with N-terminal acetylserine modification .
|
-
-
- HY-W015302
-
-
-
- HY-N16306
-
|
|
Lipid
|
Fluorescent Dye
|
|
Lyso-laurdan, a derivative of Laurdan (HY-D0080), is a fluorescent probe. Lyso-Laurdan accumulates in the lysosome via a morpholine group that is entrapped in lysosome via protonation to its cationic form in the acidic compartment. Lyso-laurdan is localized to lysosomes, allowing for the study of lysosomal membranes .
|
-
-
- HY-W016586R
-
-
-
- HY-N3018R
-
-
-
- HY-N19808
-
|
|
Structural Classification
Terpenoids
Sesquiterpenes
Plants
Compositae
Source Classification
|
Drug Derivative
|
|
2-Deacetyl-4-tigloylchamissionolide is a heliangolide-type sesquiterpene lactone, a derivative of Chamissonolide (HY-N19727), and a cytotoxic agent. 2-Deacetyl-4-tigloylchamissionolide exerts cytotoxicity via alkylating biological nucleophiles, targeting free thiol groups in proteins to interfere with their functions. 2-Deacetyl-4-tigloylchamissionolide exhibits different chromatographic behaviors in TLC and HPLC. 2-Deacetyl-4-tigloylchamissionolide can be used for the research of Ehrlich ascites carcinoma .
|
-
| Cat. No. |
Product Name |
Chemical Structure |
-
- HY-B1176S
-
|
|
|
Equilin-d4 is the deuterium labeled Equilin. Equilin (7-Dehydroestrone) is an important member of the large group of oestrogenic substances and is chemically related to menformon (oestrone). Equilin increases the growth of cortical neurons via an NMDA receptor-dependent mechanism .
|
-
-
- HY-B1176S1
-
|
|
|
Equilin-d2 (7-Dehydroestrone-d2) is deuterium labeled Equilin. Equilin (7-Dehydroestrone) is an important member of the large group of oestrogenic substances and is chemically related to menformon (oestrone). Equilin increases the growth of cortical neurons via an NMDA receptor-dependent mechanism .
|
-
-
- HY-105129AS
-
|
|
|
Pimonidazole-d10 is the deuterium labeled Pimonidazole. Pimonidazole is a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in tumor . Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after reduction of its nitro group, it can be used for qualitative and quantitative assessment of tumor hypoxia .
|
-
| Cat. No. |
Product Name |
|
Classification |
-
- HY-129832
-
Biotin-azide
Maximum Cited Publications
8 Publications Verification
N-(3-Azidopropyl)biotinamide
|
|
Azide
Labeling and Fluorescence Imaging
|
|
Biotin-azide (N-(3-Azidopropyl)biotinamide) is a form of biotin with a terminal azide group. Biotin-azide can be used to prepare various biotinylated conjugates via Click Chemistry . Biotin-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-130809
-
|
|
|
DBCO
|
|
DBCO-PEG4-Biotin is an azadibenzocyclooctyne-biotin derivative containing a biotin group and 4 PEGs. DBCO-PEG4-Biotin is a versatile biotinylation reagent used for the introduction of a biotin moiety to azide-labeled biomolecules via copper-free strain-promoted alkyne-azide click chemistry (SPAAC) reaction . DBCO-PEG4-Biotin is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
|
-
- HY-134723
-
|
|
|
ADC Synthesis
DBCO
|
|
DBCO-PEG4-GGFG-Dxd is a agent-linker conjugate for ADC with potent antitumor activity by using Dxd (a DNA topoisomerase I inhibitor), linked via the cleavable ADC linker DBCO-PEG4-GGFG . DBCO-PEG4-GGFG-Dxd is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
|
-
- HY-13728
-
|
ZD 9331; BGC9331
|
|
Alkynes
|
|
Plevitrexed (ZD 9331; BGC 9331) is an orally active and potent thymidylate synthase (TS) inhibitor with a Ki of 0.44 nM. Plevitrexed is taken up via the α-folate receptor as well as the reduced folate carrier. Plevitrexed is used for gastric cancer in clinical . Plevitrexed is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-133492
-
|
|
|
ADC Synthesis
DBCO
|
|
DBCO-PEG4-MMAF is a agent-linker conjugate for ADC with potent antitumor activity by using the tubulin polymerization inhibitor, MMAF, linked via the linker DBCO-PEG4. DBCO-PEG4-MMAF is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
|
-
- HY-133433
-
|
|
|
DBCO
|
|
DBCO-PEG4-VA-PBD is a agent-linker conjugate for ADC by using the antitumor antibiotic, Pyrrolobenzodiazepine (PBD), linked via DBCO-PEG4-VA . DBCO-PEG4-VA-PBD is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
|
-
- HY-151817
-
|
|
|
Azide
|
|
5-Azidomethyl-uridine is a click chemistry reagent containing an azide group. The azide function is widely used for coupling to alkyne-containing fragments via the renowned Click reaction.
|
-
- HY-W190943
-
|
|
|
ADC Synthesis
Azide
|
|
Azido-PEG4-Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the cleavable linker Azido-PEG4-Val-Cit-PAB-OH . Azido-PEG4-Val-Cit-PAB-MMAE is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-148835
-
|
|
|
Azide
|
|
AzGGK is an unnatural amino acid. AzGGK is site-specifically incorporated into proteins via genetic-code expansion. AzGGK can be used as site-specific probe for ubiquitylation and SUMOylation . AzGGK is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-116423
-
|
|
|
Alkynes
|
|
JH295 is a potent, irreversible and selective NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 770 nM. JH295 inhibits cellular Nek2 via alkylation of Cys22. JH295 is inactive against the mitotic kinases, Cdk1, Aurora B or Plk1, and does not perturb bipolar spindle assembly or the spindle assembly checkpoint . JH295 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-W800703
-
|
|
|
Azide
|
|
Alexa Fluor 594 azide is an azide-modified fluorescent dye and also a FRET acceptor reactant. Owing to its negligible direct absorption under 488 nm excitation light, excellent photostability, and the ability of its azide group to participate in the CuAAC reaction, Alexa Fluor 594 azide can be paired with a donor dye for single-molecule imaging via TIRFM, thereby enabling the visual monitoring of CuNP-catalyzed click reactions .
|
-
- HY-101532
-
|
β-CDN3; 6A-deoxy-6A-azido-β-cyclodextrin
|
|
Azide
|
|
6A-Azido-6A-deoxy-β-cyclodextrin (β-CDN3) is a site-specifically modified β-cyclodextrin with a single azido group replacing the hydroxyl group at the C6 position. 6A-Azido-6A-deoxy-β-cyclodextrin forms a host-guest inclusion complex with Dexamethasone (HY-14648), localizing the drug within its hydrophobic cavity, which restricts the rotational mobility of the drug and places Dexamethasone in a less polar environment. 6A-Azido-6A-deoxy-β-cyclodextrin acts as a coupling agent to graft β-cyclodextrin onto thermosensitive nanogels via strain-promoted alkyne-azide cycloaddition (SPAAC). 6A-Azido-6A-deoxy-β-cyclodextrin also serves as a click chemistry reagent. It contains an azide group and undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules bearing an alkyne group. It also undergoes strain-driven alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups .
|
-
- HY-172287
-
|
|
|
DBCO
|
|
DBCO-PEG2-Val-Cit-PAB-MMAE is an ADC linker featuring a DBCO group, a Val-Cit dipeptide, a PAB motif, and an MMAE warhead. The DBCO group is a click chemistry handle which readily reacts with azide groups, while the Val-Cit is a protease-cleavable dipeptide which releases the MMAE warhead into cells via an elimination mechanism.
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-
- HY-D1320
-
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Azide
Labeling and Fluorescence Imaging
|
|
Cyanine5 azide chloride is a potent fluorescent dye. Cyanine5 azide chloride can be reacted with terminal alkynes via a copper-catalyzed click reaction (CuAAC). (λex=646 nm, λem=662 nm) . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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-
- HY-130296
-
|
PROTAC CDK6 ligand 1
|
|
Alkynes
|
|
Palbociclib-propargyl is a ligand for target protein CDK6 for PROTAC, and binds to CRBN ligand via a PEG linker to make a PROTAC CP-10. CP-10 shows a DC50 of 2.1 nM for CDK6 . Palbociclib-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
- HY-135699
-
TD52
2 Publications Verification
|
|
Alkynes
|
|
TD52, an Erlotinib (HY-50896) derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor. TD52 mediates the apoptotic effect in triple-negative breast cancer (TNBC) cells via regulating the CIP2A/PP2A/p-Akt signalling pathway. TD52 indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter. TD52 has less p-EGFR inhibition and has potent anti-cancer activity . TD52 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
- HY-107442
-
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|
|
Alkynes
|
|
PROTAC BRD4-binding moiety 1 is a ligand for BRD4. PROTAC BRD4-binding moiety 1 binds to cereblon ligand via a linker to form PROTAC to degrade BRD4 (HY-133136) . PROTAC BRD4-binding moiety 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
- HY-131088
-
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|
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Azide
ADC Synthesis
|
|
N3-PEG8-Phe-Lys-PABC-Gefitinib is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-tumor agent, Gefitinib (HY-50895) (orally active EGFR tyrosine kinase inhibitor), linked via the cleavable linker N3-PEG8-Phe-Lys-PABC. N3-PEG8-Phe-Lys-PABC-Gefitinib is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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-
- HY-174935
-
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|
|
DBCO
|
|
DBCO-PEG1000-NHS is a dibenzocyclooctyne-conjugated polyethylene glycol derivative bearing an NHS group. DBCO-PEG-NHS forms a stable covalent linkage with the amino group of target molecules via the NHS ester at one end, while introducing a DBCO group at the other end, thus preparing for subsequent click chemical conjugation with any azide-bearing molecule or material .
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-
- HY-151859
-
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|
|
Azide
|
|
N3-Gly-Gly-Gly-OH is a click chemistry reagent containing an azide group. N3-Gly-Gly-OH undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing an alkyne group. N3-Gly-Gly-OH also undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups. N3-Gly-Gly-Gly-OH can be used to construct peptide-like ADC linkers via click chemistry .
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-
- HY-135699A
-
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|
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Alkynes
|
|
TD52 dihydrochloride, an Erlotinib (HY-50896) derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor. TD52 dihydrochloride mediates the apoptotic effect in triple-negative breast cancer (TNBC) cells via regulating the CIP2A/PP2A/p-Akt signalling pathway. TD52 dihydrochloride indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter. TD52 dihydrochloride has less p-EGFR inhibition and has potent anti-cancer activity . TD52 (dihydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
- HY-174935A
-
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|
|
DBCO
|
|
DBCO-PEG2000-NHS is a dibenzocyclooctyne-conjugated polyethylene glycol derivative bearing an NHS group. DBCO-PEG-NHS forms a stable covalent linkage with the amino group of target molecules via the NHS ester at one end, while introducing a DBCO group at the other end, thus preparing for subsequent click chemical conjugation with any azide-bearing molecule or material .
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-
- HY-132975
-
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|
Alkynes
|
|
PrDiAzK is a bifunctional amino acid. PrDiAzK can be site-selectively incorporated into proteins in both bacterial and mammalian cell culture. PrDiAzK can be used for proteome-wide incorporation via stochastic orthogonal recoding of translation (SORT) . PrDiAzK is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
- HY-151742
-
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|
|
TCO
|
|
Norbornene-methyl-NHS is a norbornene-based antibody-drug conjugate linker (ADC Linker) bearing methyl and NHS ester functional groups, which can be used for specific antibody conjugation. Norbornene-methyl-NHS is also a click chemistry reagent containing a TCO group, acting as a dienophile for conjugation via the Diels-Alder reaction, namely the copper-free click reaction with tetrazine .
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-
- HY-146231A
-
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|
PROTAC Synthesis
|
|
SS47 TFA, a PROTAC-based HPK1 degrader, exerts proteasome-mediated HPK1 degradation. The degradation of HPK1 via SS47 also significantly enhances the in vivo antitumor efficacy of BCMA CAR-T cell research. HPK1, an immunosuppressive regulatory kinase, is a promising target for cancer immunotherapies . SS47 (TFA) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
- HY-151829
-
|
|
|
Azide
|
|
Fmoc-L-Asn(EDA-N3)-OH is a click chemistry reagent containing an azide group. This building block is reported in literature for the modification of Amanitin via Click Chemistry. Alpha-Amanitin is the deadliest member of the amatoxin peptide family produced by the death-cap mushroom A. phalloides. It is an orally available, rigid, bicyclic octapeptide and one of the most lethal known natural products (LD50 = 50-100 μg/kg) acting as highly selective allosteric inhibitor of the RNA polymerase II . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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-
- HY-174929A
-
|
DBCO-PEG5000-NH2
|
|
DBCO
|
|
DBCO-PEG5000-Amine (DBCO-PEG5000-NH2) is a polyethylene glycol derivative containing dibenzocyclooctyne. DBCO-PEG-Amine is a universal, modular "bridge molecule": it forms stable covalent linkage with target materials (e.g., MSN or polymers) via the amino group at one end, while the DBCO group at the other end enables efficient, specific, and biocompatible click chemical conjugation with any azide-bearing biological entities (e.g., bacteria, cells) in subsequent steps .
|
-
- HY-160258
-
|
GDP-Fucose-Am-Tz
|
|
Tetrazine
|
|
GDP-Fucose-Tz (GDP-Fucose-Am-Tz) is a non-natural GDP-fucose analog bearing a Tetrazine group. As a precursor, GDP-Fucose-Tz enables the synthesis of GDP-fucose-ssDNA probes via inverse electron demand Diels-Alder reaction. GDP-Fucose-Tz participates in chemoenzymatic reactions to prepare GDP-fucose-Herceptin derivatives through conjugation with TCO-Herceptin .
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-
- HY-W190881
-
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Azide
|
|
N3-PEG11-CH2CH2Br is a PEG linker containing a bromine and an azide group. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The bromine (Br) is a very good leaving group for nucleophilic substitution reactions.
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-
- HY-D2167
-
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Alkynes
|
|
AF 568 alkyne is a derivative of the orange fluorescent dye AF 568. AF 568 has an absorption wavelength of 590-720 nm (FRET) and an emission wavelength of 515-720 nm. AF 568 alkyne can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) via the Alkyne group and molecules containing Azide groups. To achieve specific coupling of dye labels and biomolecules .
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-
- HY-151730
-
|
|
|
Tetrazine
|
|
(Me)Tz-butanoic acid is a click chemistry reagent containing an azide. (Me)Tz-butanoic acid is tetrazine linker for conjugation via Diels-Alder-reaction, i.e. copper-free Click reaction with dienophiles . (Me)Tz-butanoic acid is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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-
- HY-151859A
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|
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Azide
|
|
N3-Gly-Gly-OH DCHA is a click chemistry reagent containing an azide group. N3-Gly-Gly-OH DCHA undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing an alkyne group. N3-Gly-Gly-OH DCHA also undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups. N3-Gly-Gly-OH DCHA can be used to construct peptide-like ADC linkers via click chemistry .
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-
- HY-151782
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|
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Azide
|
|
The azide function is widely used for coupling to alkyne-containing fragments via the renowned Click reaction. Polyglycine fragments containing up to 7 glycines are reported to bind to surfaces and have potential application in nanotechnology constructs: constructs of Gly7-NHCH2-fragment containing peptides bind on mica surface in aqueous solution . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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-
- HY-151679
-
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|
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Azide
|
|
Fmoc-L-Lys(4-N3-Z)-OH is a click chemistry reagent containing an azide group. Fmoc-L-Lys(4-N3-Z)-OH acts as Lysine building-block for SPPS containing an Azide moiety as a bioorthogonal ligation handle, an infrared probe and a photo-affinity reagent. It can be decaged by trans-cyclooctenols via a strain-promoted 1,3-dipolar cycloaddition . Fmoc-L-Lys(4-N3-Z)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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-
- HY-174935C
-
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|
|
DBCO
|
|
DBCO-PEG5000-NHS is a dibenzocyclooctyne-conjugated polyethylene glycol derivative bearing an NHS group. DBCO-PEG-NHS forms a stable covalent linkage with the amino group of target molecules via the NHS ester at one end, while introducing a DBCO group at the other end, thus preparing for subsequent click chemical conjugation with any azide-bearing molecule or material .
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-
- HY-151687
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Azide
|
|
Fmoc-L-Tyr(2-azidoethyl)-OH is a click chemistry reagent containing an azide group. Fmoc-L-Tyr(2-azidoethyl)-OH is unnatural Fmoc-protected Tyrosine derivative bears an azidoethyl substitution as reactive handle e.g. for biorthogonal conjugations, via a Cu(I)-catalyzed 1,3-dipolar Click cycloaddition with alkynes. And azido-UAAs can be employed as IR reporters . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
|
-
- HY-174929
-
|
DBCO-PEG3400-NH2
|
|
DBCO
|
|
DBCO-PEG3400-Amine (DBCO-PEG3400-NH2) is a polyethylene glycol derivative containing dibenzocyclooctyne. DBCO-PEG-Amine is a universal, modular "bridge molecule": it forms stable covalent linkage with target materials (e.g., MSN or polymers) via the amino group at one end, while the DBCO group at the other end enables efficient, specific, and biocompatible click chemical conjugation with any azide-bearing biological entities (e.g., bacteria, cells) in subsequent steps .
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-
- HY-116423A
-
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Alkynes
|
|
JH295 hydrate is a potent, irreversible and selective NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 770 nM. JH295 hydrate inhibits cellular Nek2 via alkylation of Cys22. JH295 hydrate is inactive against the mitotic kinases, Cdk1, Aurora B or Plk1, and does not perturb bipolar spindle assembly or the spindle assembly checkpoint . JH295 (hydrate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
- HY-107453
-
|
PROTAC Sirt2-binding moiety 1
|
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Alkynes
|
|
SirReal1-O-propargyl is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC50 of 2.4 μM. SirReal1-O-propargyl, the SirReal1-based moiety, binds to the cereblon ligand via a linker to form PROTAC to degrade Sirt2 . SirReal1-O-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
- HY-151704
-
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|
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Alkynes
|
|
ICG-alkyne is a short-wave infrared (SWIR)-emitting cyanine fluorescent probe based on alkyne-derivatized indocyanine green. ICG-alkyne can undergo click chemistry reaction to conjugate with antibody molecules via binding to the azide groups introduced into antibodies. ICG-alkyne enables SWIR fluorescent molecular imaging of breast tumors in living mice. ICG-alkyne can be used in breast cancer-related research .
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-
- HY-131088A
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Azide
|
|
N3-PEG8-Phe-Lys-PABC-Gefitinib TFA is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-tumor agent, Gefitinib (HY-50895) (orally active EGFR tyrosine kinase inhibitor), linked via the cleavable linker N3-PEG8-Phe-Lys-PABC. N3-PEG8-Phe-Lys-PABC-Gefitinib TFA is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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-
- HY-W800657
-
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|
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Azide
|
|
Azido-PEG1-hydrazide hydrochloride is a bifunctional PEG linker containing an azide group and a hydrazide group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. Hydrazine moiety reacts with an aldehyde to form semi-permanent hydrazone bonds.
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-
- HY-D2748
-
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Azide
|
|
5-JOE azide is a fluorescent dye with the emission in yellow region of the spectrum. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.
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-
- HY-174935B
-
|
|
|
DBCO
|
|
DBCO-PEG3400-NHS is a dibenzocyclooctyne-conjugated polyethylene glycol derivative bearing an NHS group. DBCO-PEG-NHS forms a stable covalent linkage with the amino group of target molecules via the NHS ester at one end, while introducing a DBCO group at the other end, thus preparing for subsequent click chemical conjugation with any azide-bearing molecule or material .
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-
- HY-174935D
-
|
|
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DBCO
|
|
DBCO-PEG10000-NHS is a dibenzocyclooctyne-conjugated polyethylene glycol derivative bearing an NHS group. DBCO-PEG-NHS forms a stable covalent linkage with the amino group of target molecules via the NHS ester at one end, while introducing a DBCO group at the other end, thus preparing for subsequent click chemical conjugation with any azide-bearing molecule or material .
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-
- HY-D2156
-
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|
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Azide
|
|
AF 430 azide is a derivative of the yellow fluorescent dye AF 430. AF430 has an excitation wavelength of 425 nm and an emission wavelength of 542 nm. AF 430 azide can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) via the azide group and molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. To achieve specific coupling of dye labels and biomolecules .
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-
- HY-151691
-
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|
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Tetrazine
|
|
Trisulfo-Cy3 Methyltetrazine is a click chemistry reagent containing an methyltetrazine group. Methyltetrazine-activated Cy3 probe reacts with TCO-containing compounds via an Inverse-Electron-Demand Diels-Alder reaction to form a stable covalent bond and does not require Cu-catalyst or elevated temperatures .
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-
- HY-W457953
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|
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Azide
|
|
tert-Butyl N-(4-azidobutyl)carbamate is N-Boc protected crosslinker. tert-Butyl N-(4-azidobutyl)carbamate can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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-
- HY-W591390
-
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|
|
Azide
|
|
6-Azidohexanoic Acid STP Ester is an amine-reactive, water-soluble labeling reagent with an azide group and a terminal 4-Sulfo-2,3,5,6-tetrafluorophenyl (STP) group. 6-Azidohexanoic Acid STP Ester is used to modify proteins, antibodies, and other amine-containing biopolymers in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. STP esters can react with primary amines, forming covalent amide bonds, and typically display much better stability toward hydrolysis in aqueous media, resulting in more efficiency and better reproducible labeling of biopolymers.
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-
- HY-W800717
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|
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Azide
|
|
Tetra-(amido-PEG10-azide) is a branched PEG linker with four terminal azide groups. The azide groups enable PEGylation via Click Chemistry.
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- HY-W591376
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|
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Azide
|
|
Azido-PEG19-azide is a click chemistry reagent with two terminal azide groups. The azide groups can react with alkyne, BCN, DBCO via Click Chemistry.
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- HY-W800716
-
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|
|
Azide
|
|
Tri(Azide-PEG10-NHCO-ethyloxyethyl)amine is a branched PEG linker with three terminal azide groups. The azide groups enable PEGylation via Click Chemistry.
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- HY-W840196
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Alkynes
|
|
Hex-5-ynehydrazide is a bifunctional linker reagent with a terminal hydrazide group and a propargyl group. The hydrazide group can react with an aldehyde to form a semi-permanent hydrozone bond. The propargyl group can be linked to azide-containing biomolecules via Click Chemistry.
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- HY-W590592
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Azide
|
|
Azido-PEG12-azide is a monodisperse PEG linker containing two azide groups. The azide group can react with alkyne, BCN, or DBCO via Click Chemistry to yield a stable triazole linkage.
|
- HY-W598193
-
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|
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Azide
|
|
[(5-Azidopentyl)oxy](tert-butyl)dimethylsilane is a silane compound with a terminal azide group. The trimethylsilane is commonly used for surface modifications. The terminal azide (N3) group can react with alkyne, BCN, DBCO via Click Chemistry.
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- HY-W590575
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Azide
|
|
Azido-PEG3-flouride is a PEG linker containing a fluorine atom and an azide group. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.
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- HY-W800664
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Azide
|
|
5-(Azido-PEG4)-pent-2-yn-1-Ol is a PEG linker containing an azide group and a terminal hydroxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.
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- HY-W591360
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Azide
|
|
Iodoacetamido-PEG6-azide is an aqueous soluble PEG linker containing an azide and a terminal Iodoacetamido group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The Iodoacetamido moiety is commonly used to bind covalently with the thiol group of cysteine so the protein cannot form disulfide bonds.
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- HY-W1052510
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Azide
|
|
N3-PEG2-CH2CO2-NHS is a PEG derivative containing an azide group and an NHS ester. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.
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- HY-183038
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Alkynes
|
|
2-Phenyl-1-octen-7-yn-1-one is an alkyne-functionalized enone with site-selective reactivity toward the N-terminal α-amino group of peptides and proteins. 2-Phenyl-1-octen-7-yn-1-one can undergo click chemistry with azides via its alkyne moiety to enable further protein functionalization. 2-Phenyl-1-octen-7-yn-1-one modifies unprotected peptide libraries as well as proteins including insulin, lysozyme, RNaseA and BCArg .
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| Cat. No. |
Product Name |
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Classification |
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- HY-W440896
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Pegylated Lipids
|
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DSPE-PEG2000-SH is an amphiphilic thiol-functionalized DSPE-PEG molecule. DSPE-PEG2000-SH inserts into extracellular vesicle (EV) bilayer membranes via hydrophobic interactions, displaying surface thiol groups to form EV-SH crosslinkers.DSPE-PEG2000-SH enables crosslinking of EV-SH with 8-arm PEG-norbornene via thiol-ene photochemistry to construct hydrogels, with hydrogel mechanical properties tunable via PEG segment molecular weight variation.DSPE-PEG2000-SH can be used to encapsulate agents for drug delivery system, such as mRNA vaccine .
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-
- HY-151817
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|
|
Nucleoside Analogs
Uridine
|
|
5-Azidomethyl-uridine is a click chemistry reagent containing an azide group. The azide function is widely used for coupling to alkyne-containing fragments via the renowned Click reaction.
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-
- HY-150726
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CpG ODNs
|
|
ODN 1668, a class B CpG ODN (oligodeoxynucleotide), is a TLR-9 agonist. ODN 1668 has strong immune regulatory properties, can enhance the level of antibody IgG2 subtype, promote the immune response of T cells and B cells, and can be used in the study of vaccine adjuvants. In addition, CpG ODN 1668 induces an antimicrobial immune response via a CaTLR9 dependent pathway in groupers. Sequence: 5'-tccatgacgttcctgatgct-3’ .
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-
- HY-150726C
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CpG ODNs
|
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ODN 1668 sodium, a class B CpG ODN (oligodeoxynucleotide), is a TLR-9 agonist. ODN 1668 sodium has strong immune regulatory properties, can enhance the level of antibody IgG2 subtype, promote the immune response of T cells and B cells, and can be used in the study of vaccine adjuvants. In addition, CpG ODN 1668 sodium induces an antimicrobial immune response via a CaTLR9 dependent pathway in groupers. Sequence: 5'-tccatgacgttcctgatgct-3’ .
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-
- HY-101530B
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PEG 40 stearate
|
|
Emulsifiers
Bases
Solubilizing Agents
|
|
Polyoxyl 40 stearate (PEG 40 stearate) is a nonionic surfactant formed by the esterification of stearic acid with polyethylene glycol (PEG) containing approximately 40 ethoxy units, it is widely used in pharmaceutical preparations, nanodrug carriers, emulsification systems and biomedical materials. Polyoxyl 40 stearate can serve as a matrix component of solid lipid nanoparticles to achieve controlled release of encapsulated antifungal drugs; it can also act as a base material for solid lipid nanoparticles for vaginal administration, and polymerizable groups can be introduced via modification with acryloyl chloride .
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-
- HY-172270D
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Pegylated Lipids
|
|
DSPE-PEG1000-PTP is synthesised by conjugating the amino group of plectin-1 peptide (PTP) with DSPE-PEG-NHS ester via amide bonds. DSPE-PEG1000-PTP can be used to construct drug delivery vectors .
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-
- HY-172270
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Pegylated Lipids
|
|
DSPE-PEG1000-PTP is synthesised by conjugating the amino group of plectin-1 peptide (PTP) with DSPE-PEG-NHS ester via amide bonds. DSPE-PEG1000-PTP can be used to construct drug delivery vectors .
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-
- HY-172270A
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Pegylated Lipids
|
|
DSPE-PEG1000-PTP is synthesised by conjugating the amino group of plectin-1 peptide (PTP) with DSPE-PEG-NHS ester via amide bonds. DSPE-PEG1000-PTP can be used to construct drug delivery vectors .
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-
- HY-165427
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Cationic Lipids
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|
Lipid 11 (Compound Lipid 1) is a cationic lipid for nucleic acid delivery. Lipid 11 forms lipid nanoparticles (LNPs) through electrostatic binding with nucleic acids (such as ceDNA). Lipid 11 forms complexes with negatively charged nucleic acids via cationic amine groups, which can be endocytosed by cells to release nucleic acids for activity. Lipid 11 is promising for research of gene therapy drug delivery systems .
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-
- HY-172270C
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Pegylated Lipids
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DSPE-PEG1000-PTP is synthesised by conjugating the amino group of plectin-1 peptide (PTP) with DSPE-PEG-NHS ester via amide bonds. DSPE-PEG1000-PTP can be used to construct drug delivery vectors .
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- HY-185273
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Nucleotide Analogs
Guanine Nucleotide
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3'-O-(2-Nitrobenzyl)-dGTP is a reversible terminator. 3'-O-(2-Nitrobenzyl)-dGTP can be recognized and incorporated by DNA polymerases, thereby temporarily terminating DNA primer extension; after the 2-nitrobenzyl blocking group is removed via laser irradiation, a free 3'-OH can be regenerated to allow subsequent polymerase-mediated extension. 3'-O-(2-Nitrobenzyl)-dGTP can be used in DNA sequencing studies .
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- HY-177901
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Nucleotide Analogs
Adenine Nucleotide
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3'-O-(2-Nitrobenzyl)-dATP is a reversible and photolabile DNA synthesis terminator. 3'-O-(2-Nitrobenzyl)-dATP incorporates into growing DNA strands to terminate synthesis in a base-specific manner. 3'-O-(2-Nitrobenzyl)-dATP undergoes efficient photolytic removal of its 3'-protecting group upon UV exposure to enable reinitiation of DNA synthesis. 3'-O-(2-Nitrobenzyl)-dATP supports development of the Base Addition Sequencing Scheme (BASS) via a complete stop-start DNA synthesis cycle .
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