N3-PEG8-Phe-Lys-PABC-Gefitinib
N3-PEG8-Phe-Lys-PABC-Gefitinib is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-tumor agent, Gefitinib (HY-50895) (orally active EGFR tyrosine kinase inhibitor), linked via the cleavable linker N3-PEG8-Phe-Lys-PABC. N3-PEG8-Phe-Lys-PABC-Gefitinib is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
For research use only. We do not sell to patients.
- Formula: C60H81ClFN11O15
- Molecular Weight:1250.80
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
Biological Activity
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Traditional Cytotoxic Agents |
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 1250.80
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Formula C60H81ClFN11O15
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SMILES
ClC1=C(C=CC(NC2=NC=NC3=C2C=C(C(OC)=C3)OCCCNC(OCC4=CC=C(NC([C@H](CCCCN)NC([C@@H](NC(CCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])=O)CC5=CC=CC=C5)=O)=O)C=C4)=O)=C1)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
DMSO : 50 mg/mL (39.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.7995 mL | 3.9974 mL | 7.9949 mL | 19.9872 mL |
| 5 mM | 0.1599 mL | 0.7995 mL | 1.5990 mL | 3.9974 mL | |
| 10 mM | 0.0799 mL | 0.3997 mL | 0.7995 mL | 1.9987 mL | |
| 15 mM | 0.0533 mL | 0.2665 mL | 0.5330 mL | 1.3325 mL | |
| 20 mM | 0.0400 mL | 0.1999 mL | 0.3997 mL | 0.9994 mL | |
| 25 mM | 0.0320 mL | 0.1599 mL | 0.3198 mL | 0.7995 mL | |
| 30 mM | 0.0266 mL | 0.1332 mL | 0.2665 mL | 0.6662 mL |
N3-PEG8-Phe-Lys-PABC-Gefitinib Related Classifications
HY-131088 Related Classifications
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