N3-PEG8-Phe-Lys-PABC-Gefitinib

製品番号: HY-131088: Data Sheet 取扱説明書
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N3-PEG8-Phe-Lys-PABC-Gefitinib is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-tumor agent, Gefitinib (HY-50895) (orally active EGFR tyrosine kinase inhibitor), linked via the cleavable linker N3-PEG8-Phe-Lys-PABC. N3-PEG8-Phe-Lys-PABC-Gefitinib is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

N3-PEG8-Phe-Lys-PABC-Gefitinib 構造式

容量		在庫状況
MOQ		Minimum order quantity
50 mg		お問い合わせ
100 mg		お問い合わせ
250 mg		お問い合わせ
Other size		お問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

Other 在庫あり Forms of N3-PEG8-Phe-Lys-PABC-Gefitinib:

N3-PEG8-Phe-Lys-PABC-Gefitinib TFA

Other Forms of N3-PEG8-Phe-Lys-PABC-Gefitinib:

N3-PEG8-Phe-Lys-PABC-Gefitinib TFA 在庫あり

Drug-Linker Conjugates for ADC アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents Dual payloads

EGFR アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

生物活性
純度とドキュメンテーション
カスタマーレビュー

製品説明

IC₅₀ & Target

Traditional Cytotoxic Agents

体外実験

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1250.80

分子式

C₆₀H₈₁ClFN₁₁O₁₅

SMILES

ClC1=C(C=CC(NC2=NC=NC3=C2C=C(C(OC)=C3)OCCCNC(OCC4=CC=C(NC([C@H](CCCCN)NC([C@@H](NC(CCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])=O)CC5=CC=CC=C5)=O)=O)C=C4)=O)=C1)F

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

溶剤 & 溶解度

体外:

DMSO : 50 mg/mL (39.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.7995 mL	3.9974 mL	7.9949 mL
5 mM	0.1599 mL	0.7995 mL	1.5990 mL
10 mM	0.0799 mL	0.3997 mL	0.7995 mL

View the Complete Stock Solution Preparation Table

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

取扱説明書 (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.7995 mL	3.9974 mL	7.9949 mL	19.9872 mL
	5 mM	0.1599 mL	0.7995 mL	1.5990 mL	3.9974 mL
	10 mM	0.0799 mL	0.3997 mL	0.7995 mL	1.9987 mL
	15 mM	0.0533 mL	0.2665 mL	0.5330 mL	1.3325 mL
	20 mM	0.0400 mL	0.1999 mL	0.3997 mL	0.9994 mL
	25 mM	0.0320 mL	0.1599 mL	0.3198 mL	0.7995 mL
	30 mM	0.0266 mL	0.1332 mL	0.2665 mL	0.6662 mL