SARS-CoV-2 Mpro-IN-57
SARS-CoV-2 Mpro-IN-57 is an irreversible SARS-CoV-2 main protease inhibitor with an IC50 of 0.41 μM and a Kd of 247.37 nM. SARS-CoV-2 Mpro-IN-57 forms a covalent bond with the key amino acid residue Cys145 in SARS-CoV-2 main protease via its -CN group. SARS-CoV-2 Mpro-IN-57 can be used for the research of COVID-19.
For research use only. We do not sell to patients.
- CAS No.: 3031240-80-6
- Formula: C11H8N2O2Se
- Molecular Weight:279.15
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
SARS-CoV-2 Mpro-IN-57 (compound 3ab) (15 min) potently inhibits purified recombinant SARS-CoV-2 Mpro, with an IC50 of 0.41 μM, and achieves complete inhibition at a concentration of 100 μM[1].
SARS-CoV-2 Mpro-IN-57 forms a covalent bond with the Cys145 residue of SARS-CoV-2 Mpro, while forming an auxiliary hydrogen bond with His41 and a Pi-alkyl interaction with Met49[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3031240-80-6
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Molecular Weight 279.15
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Formula C11H8N2O2Se
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SMILES
O=C(OC)C1(N=C1C2=CC=CC=C2)[Se]C#N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SARS-CoV-2 Mpro-IN-57 Related Classifications
HY-182754 Related Classifications
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