2,4-Difluorophenylethynylcobalamin
Based on 1 Customer Validation
2,4-Difluorophenylethynylcobalamin is a potential B12 antivitamin via binding to human B12 -processing enzyme CblC with high affinity (KD=130 nm). 2,4-Difluorophenylethynylcobalamin withstood tailoring by CblC, and stabilizes the ternary complex with the cosubstrate glutathione (GSH). 2,4-Difluorophenylethynylcobalamin is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.97%
- CAS 番号: 2101750-19-8
- 分子式: C70H91CoF2N13O14P
- 分子量:1466.45
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
B12 -processing enzyme CblC[1]
化学情報
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CAS 番号 2101750-19-8
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性状 Solid
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分子量 1466.45
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分子式 C70H91CoF2N13O14P
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Color Brown to red
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SMILES
C[C@]1([C@](C)2CC(N)=O)[N]([Co+3]([N-]3[C@]1([H])[C@@H]4CC(N)=O)([N](C([C@](C)5CC(N)=O)=C6C)=C7[C@H]5CCC(N)=O)([N](C(C(C)8C)=C7)=C([C@H]8CCC(N)=O)C(C)=C3[C@@]4(CCC(NC[C@H]9C)=O)C)([N](C%10=C%11)=CN([C@@H](O[C@@H]%12CO)[C@]([C@@H]%12O[P]([O-])(O9)=O)([H])O)C%10=CC(C)=C%11C)[C-]#CC(C=CC(F)=C%13)=C%13F)=C6[C@H]2CCC(N)=O
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別名
F2PhEtyCbl
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (68.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (290 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.6819 mL | 3.4096 mL | 6.8192 mL | 17.0480 mL |
| 5 mM | 0.1364 mL | 0.6819 mL | 1.3638 mL | 3.4096 mL | |
| 10 mM | 0.0682 mL | 0.3410 mL | 0.6819 mL | 1.7048 mL | |
| 15 mM | 0.0455 mL | 0.2273 mL | 0.4546 mL | 1.1365 mL | |
| 20 mM | 0.0341 mL | 0.1705 mL | 0.3410 mL | 0.8524 mL | |
| 25 mM | 0.0273 mL | 0.1364 mL | 0.2728 mL | 0.6819 mL | |
| 30 mM | 0.0227 mL | 0.1137 mL | 0.2273 mL | 0.5683 mL | |
| 40 mM | 0.0170 mL | 0.0852 mL | 0.1705 mL | 0.4262 mL | |
| 50 mM | 0.0136 mL | 0.0682 mL | 0.1364 mL | 0.3410 mL | |
| 60 mM | 0.0114 mL | 0.0568 mL | 0.1137 mL | 0.2841 mL |
2,4-Difluorophenylethynylcobalamin 関連分類
HY-154992 関連分類
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