2,4-Difluorophenylethynylcobalamin
Based on 1 Customer Validation
2,4-Difluorophenylethynylcobalamin is a potential B12 antivitamin via binding to human B12 -processing enzyme CblC with high affinity (KD=130 nm). 2,4-Difluorophenylethynylcobalamin withstood tailoring by CblC, and stabilizes the ternary complex with the cosubstrate glutathione (GSH). 2,4-Difluorophenylethynylcobalamin is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- Purity: 98.97%
- CAS No.: 2101750-19-8
- Formula: C70H91CoF2N13O14P
- Molecular Weight:1466.45
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
B12 -processing enzyme CblC[1]
Chemical Information
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CAS No. 2101750-19-8
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Appearance Solid
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Molecular Weight 1466.45
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Formula C70H91CoF2N13O14P
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Color Brown to red
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SMILES
C[C@]1([C@](C)2CC(N)=O)[N]([Co+3]([N-]3[C@]1([H])[C@@H]4CC(N)=O)([N](C([C@](C)5CC(N)=O)=C6C)=C7[C@H]5CCC(N)=O)([N](C(C(C)8C)=C7)=C([C@H]8CCC(N)=O)C(C)=C3[C@@]4(CCC(NC[C@H]9C)=O)C)([N](C%10=C%11)=CN([C@@H](O[C@@H]%12CO)[C@]([C@@H]%12O[P]([O-])(O9)=O)([H])O)C%10=CC(C)=C%11C)[C-]#CC(C=CC(F)=C%13)=C%13F)=C6[C@H]2CCC(N)=O
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Synonyms
F2PhEtyCbl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (68.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (290 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.6819 mL | 3.4096 mL | 6.8192 mL | 17.0480 mL |
| 5 mM | 0.1364 mL | 0.6819 mL | 1.3638 mL | 3.4096 mL | |
| 10 mM | 0.0682 mL | 0.3410 mL | 0.6819 mL | 1.7048 mL | |
| 15 mM | 0.0455 mL | 0.2273 mL | 0.4546 mL | 1.1365 mL | |
| 20 mM | 0.0341 mL | 0.1705 mL | 0.3410 mL | 0.8524 mL | |
| 25 mM | 0.0273 mL | 0.1364 mL | 0.2728 mL | 0.6819 mL | |
| 30 mM | 0.0227 mL | 0.1137 mL | 0.2273 mL | 0.5683 mL | |
| 40 mM | 0.0170 mL | 0.0852 mL | 0.1705 mL | 0.4262 mL | |
| 50 mM | 0.0136 mL | 0.0682 mL | 0.1364 mL | 0.3410 mL | |
| 60 mM | 0.0114 mL | 0.0568 mL | 0.1137 mL | 0.2841 mL |
2,4-Difluorophenylethynylcobalamin Related Classifications
HY-154992 Related Classifications
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