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  4. 2,4-Difluorophenylethynylcobalamin

2,4-Difluorophenylethynylcobalamin  (Synonyms: F2PhEtyCbl)

Cat. No.: HY-154992 Purity: 99.73%
COA Handling Instructions

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2,4-Difluorophenylethynylcobalamin is a potential B12 antivitamin via binding to human B12 -processing enzyme CblC with high affinity (KD=130 nm). 2,4-Difluorophenylethynylcobalamin withstood tailoring by CblC, and stabilizes the ternary complex with the cosubstrate glutathione (GSH). 2,4-Difluorophenylethynylcobalamin is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

2,4-Difluorophenylethynylcobalamin Chemical Structure

2,4-Difluorophenylethynylcobalamin Chemical Structure

CAS No. : 2101750-19-8

Size Price Stock Quantity
1 mg USD 245 In-stock
5 mg USD 539 In-stock
10 mg USD 862 In-stock
25 mg USD 1811 In-stock
50 mg USD 2897 In-stock
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Based on 1 publication(s) in Google Scholar

2,4-Difluorophenylethynylcobalamin Related Antibodies

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Description

2,4-Difluorophenylethynylcobalamin is a potential B12 antivitamin via binding to human B12 -processing enzyme CblC with high affinity (KD=130 nm). 2,4-Difluorophenylethynylcobalamin withstood tailoring by CblC, and stabilizes the ternary complex with the cosubstrate glutathione (GSH)[1]. 2,4-Difluorophenylethynylcobalamin is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

B12 -processing enzyme CblC[1]
Molecular Weight

1466.45

Formula

C70H91CoF2N13O14P
CAS No.
Appearance

Solid

Color

Brown to red

SMILES

C[C@]1([C@](C)2CC(N)=O)[N]([Co+3]([N-]3[C@]1([H])[C@@H]4CC(N)=O)([N](C([C@](C)5CC(N)=O)=C6C)=C7[C@H]5CCC(N)=O)([N](C(C(C)8C)=C7)=C([C@H]8CCC(N)=O)C(C)=C3[C@@]4(CCC(NC[C@H]9C)=O)C)([N](C%10=C%11)=CN([C@@H](O[C@@H]%12CO)[C@]([C@@H]%12O[P]([O-])(O9)=O)([H])O)C%10=CC(C)=C%11C)[C-]#CC(C=CC(F)=C%13)=C%13F)=C6[C@H]2CCC(N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (68.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6819 mL 3.4096 mL 6.8192 mL
5 mM 0.1364 mL 0.6819 mL 1.3638 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6819 mL 3.4096 mL 6.8192 mL 17.0480 mL
5 mM 0.1364 mL 0.6819 mL 1.3638 mL 3.4096 mL
10 mM 0.0682 mL 0.3410 mL 0.6819 mL 1.7048 mL
15 mM 0.0455 mL 0.2273 mL 0.4546 mL 1.1365 mL
20 mM 0.0341 mL 0.1705 mL 0.3410 mL 0.8524 mL
25 mM 0.0273 mL 0.1364 mL 0.2728 mL 0.6819 mL
30 mM 0.0227 mL 0.1137 mL 0.2273 mL 0.5683 mL
40 mM 0.0170 mL 0.0852 mL 0.1705 mL 0.4262 mL
50 mM 0.0136 mL 0.0682 mL 0.1364 mL 0.3410 mL
60 mM 0.0114 mL 0.0568 mL 0.1137 mL 0.2841 mL
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2,4-Difluorophenylethynylcobalamin Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2,4-Difluorophenylethynylcobalamin2101750-19-8F2PhEtyCblOthersInhibitorinhibitorinhibit

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