Azido-PEG4-Val-Cit-PAB-MMAE
Based on 1 publication(s) in Google Scholar
Azido-PEG4-Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the cleavable linker Azido-PEG4-Val-Cit-PAB-OH. Azido-PEG4-Val-Cit-PAB-MMAE is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
For research use only. We do not sell to patients.
- Purity: 99.43%
- CAS No.: 1869126-64-6
- Formula: C69H113N13O17
- Molecular Weight:1396.71
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Storage:
-20°C, protect from light, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-15575
VcMMAE
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HY-136314
DBCO-PEG4-VC-PAB-MMAE
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HY-15575G
VcMMAE (GMP)
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HY-141154
Amino-PEG4-Val-Cit-PAB-MMAE
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HY-19811
Fmoc-Val-Cit-PAB-MMAE
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HY-15575R
VcMMAE (Standard)
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HY-20336
Mc-Val-Cit-PABC-PNP
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HY-112786
MC-Val-Cit-PAB-MMAF
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HY-12362
Val-cit-PAB-OH
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HY-41189
Fmoc-Val-Cit-PAB-PNP
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HY-78738
MC-Val-Cit-PAB
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HY-19318
Fmoc-Val-Cit-PAB
Publications Citing Use of MedChemExpress (MCE) Azido-PEG4-Val-Cit-PAB-MMAE
MoreAll Drug-Linker Conjugates for ADC Isoforms
More
Biological Activity
Drug-Linker Conjugates for ADC[1]
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1869126-64-6
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Appearance Solid
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Molecular Weight 1396.71
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Formula C69H113N13O17
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Color White to off-white
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SMILES
O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCN=[N+]=[N-])=O)=O)=O)=O)=O)=O)=O)OC)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
Publications (1)
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Journal Impact Factor
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Most Recent
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J Med Chem
2025 Mar 28. PMID: 40152348
Solvent & Solubility
H2O : < 0.1 mg/mL (insoluble)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Azido-PEG4-Val-Cit-PAB-MMAE Related Classifications
HY-W190943 Related Classifications
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