Azido-PEG4-Val-Cit-PAB-MMAE

Cat. No.: HY-W190943 Purity: 99.36%: FAQs
Data Sheet SDS COA Handling Instructions

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Azido-PEG4-Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the cleavable linker Azido-PEG4-Val-Cit-PAB-OH. Azido-PEG4-Val-Cit-PAB-MMAE is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

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Azido-PEG4-Val-Cit-PAB-MMAE Chemical Structure

CAS No. : 1869126-64-6

Size	Price	Stock	Quantity
1 mg	USD 650	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1450	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 2350	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Description	Azido-PEG4-Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the cleavable linker Azido-PEG4-Val-Cit-PAB-OH^[1]. Azido-PEG4-Val-Cit-PAB-MMAE is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
IC₅₀ & Target	Drug-Linker Conjugates for ADC^[1]
Molecular Weight	1396.71
Formula	C₆₉H₁₁₃N₁₃O₁₇
CAS No.	1869126-64-6
Appearance	Solid
Color	White to off-white
SMILES	O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCN=[N+]=[N-])=O)=O)=O)=O)=O)=O)=O)OC)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	-20°C, protect from light, stored under nitrogen *The compound is unstable in solutions, freshly prepared is recommended.
Purity & Documentation	Purity: 99.36% Select Batch: Data Sheet (268 KB) SDS (393 KB) COA (253 KB) LCMS (268 KB) Elemental Analysis Report (111 KB) Handling Instructions (2659 KB)
References	[1]. Moreadith R, et, al. Polyoxazoline antibody drug conjugates. WO2016019340A1.