Azido-PEG4-Val-Cit-PAB-MMAE

Cat. No.: HY-W190943 Purity: 99.43%: Data Sheet
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Azido-PEG4-Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the cleavable linker Azido-PEG4-Val-Cit-PAB-OH. Azido-PEG4-Val-Cit-PAB-MMAE is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

For research use only. We do not sell to patients.

Azido-PEG4-Val-Cit-PAB-MMAE Chemical Structure

CAS No. : 1869126-64-6

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE Azido-PEG4-Val-Cit-PAB-MMAE

•J Med Chem. 2025 Mar 28. [Abstract]

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Description	Azido-PEG4-Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the cleavable linker Azido-PEG4-Val-Cit-PAB-OH^[1]. Azido-PEG4-Val-Cit-PAB-MMAE is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC₅₀ & Target	Drug-Linker Conjugates for ADC^[1]
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Azido-PEG4-Val-Cit-PAB-MMAE Related Antibodies
Molecular Weight	1396.71
Formula	C₆₉H₁₁₃N₁₃O₁₇
CAS No.	1869126-64-6
Appearance	Solid
Color	White to off-white
SMILES	O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCN=[N+]=[N-])=O)=O)=O)=O)=O)=O)=O)OC)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	-20°C, protect from light, stored under nitrogen *The compound is unstable in solutions, freshly prepared is recommended.
Solvent & Solubility	In Vitro: H₂O : < 0.1 mg/mL (insoluble) Molarity Calculator Dilution Calculator Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Mass = Concentration × Volume × Molecular Weight * Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final) This equation is commonly abbreviated as: C₁V₁ = C₂V₂ Concentration _(start) C1 × Volume _(start) V1 = Concentration _(final) C2 × Volume _(final) V2 In Vivo Dissolution Calculator Please enter the basic information of animal experiments: Dosage mg/kg Animal weight (per animal) g Dosing volume (per animal) μL Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments. Calculation results: Working solution concentration: mg/mL
Purity & Documentation	Purity: 99.43% Select Batch: Data Sheet (272 KB) SDS (393 KB) COA (253 KB) LCMS (103 KB) Elemental Analysis Report (111 KB) Handling Instructions (2659 KB)
References	[1]. Moreadith R, et, al. Polyoxazoline antibody drug conjugates. WO2016019340A1.