1. Antibody-drug Conjugate/ADC Related
  2. ADC Linker
  3. Val-cit-PAB-OH

Val-cit-PAB-OH 

Cat. No.: HY-12362 Purity: 99.62%
COA Handling Instructions

Val-cit-PAB-OH is a cleavable ADC linker.

For research use only. We do not sell to patients.

Val-cit-PAB-OH Chemical Structure

Val-cit-PAB-OH Chemical Structure

CAS No. : 159857-79-1

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100 mg USD 30 In-stock
500 mg USD 55 In-stock
1 g USD 85 In-stock
5 g USD 330 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Val-cit-PAB-OH:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

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Description

Val-cit-PAB-OH is a cleavable ADC linker.

IC50 & Target

Protease Cleavable Linker

 

Cleavable Linker

 

Molecular Weight

379.45

Formula

C18H29N5O4

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(CO)C=C1)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (263.54 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6354 mL 13.1770 mL 26.3539 mL
5 mM 0.5271 mL 2.6354 mL 5.2708 mL
10 mM 0.2635 mL 1.3177 mL 2.6354 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (5.48 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (5.48 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.08 mg/mL (5.48 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.62%

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Val-cit-PAB-OH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Val-cit-PAB-OH
Cat. No.:
HY-12362
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