Antibacterial agent 336
Antibacterial agent 336 is an antibacterical agent with broad-spectrum inhibitory activity against Gram-negative and Gram-positive bacteria. Antibacterial agent 336 binds tightly via its pyridine group to the carboxyl group, Lys-465 residue, and Leu-480 residue of the MsbA protein, interfering with bacterial outer membrane synthesis, and exerts concentration-dependent bactericidal activity against bacterial. Antibacterial agent 336 has low cytotoxicity to normal human liver cells. Antibacterial agent 336 can be used for the research of bacterial infections.
For research use only. We do not sell to patients.
- Formula: C22H28N4O3S
- Molecular Weight:428.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Antibacterial agent 336 (Compound z10) exhibits broad-spectrum in vitro antibacterial activity against E. coli ATCC 25922, Salmonella ATCC 12022, S. aureus ATCC 25922, and P. aeruginosa ATCC 27853 with MIC values of 1.40, 1.40, 1.75, and 2.33 μM, respectively[1].
Antibacterial agent 336 exhibits low in vitro cytotoxicity toward normal human liver L02 cells, with an IC50 of 378.6 μM and a selectivity index of 216.3[1].
Antibacterial agent 336 (0.5×MIC-2×MIC; 2-25 h) exerts a concentration-dependent bactericidal effect against E. coli ATCC 25922, P. aeruginosa ATCC 27853, Salmonella ATCC 12022, and S. aureus ATCC 25922, with significant bacterial kill observed within 2 h at 1×MIC and 2×MIC concentrations[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 428.55
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Formula C22H28N4O3S
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SMILES
CCC1CCC(C(C(O)=O)=C(NC(CN2CCN(C3=NC=CC=C3)CC2)=O)S4)=C4C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antibacterial agent 336 Related Classifications
HY-182784 Related Classifications
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- Antibacterial agent 336
- Antibacterial agent336
- Antibacterial agent-336
- Bacterial
- MsbA protein
- P. aeruginosa ATCC 27853
- S. aureus ATCC 25922
- Gram-negative bacteria
- bacterial outer membrane synthesis
- Salmonella ATCC 12022
- normal human liver L02 cells
- normal human liver cells
- Gram-positive bacteria
- E. coli ATCC 25922
- Inhibitor
- inhibitor
- inhibit