(Rac)-Metanephrine hydrochloride
Based on 1 Customer Validation
(Rac)-Metanephrine hydrochloride is a metabolite of epinephrine and a substrate of the sulfotransferase SULT1A3. (Rac)-Metanephrine hydrochloride undergoes sulfonation at its p-hydroxyl group via a reaction catalyzed by SULT1A3. (Rac)-Metanephrine hydrochloride is an isomer of Metanephrine (HY-113299) hydrochloride, and it is applicable to the research of pheochromocytoma.
For research use only. We do not sell to patients.
- Purity: 99.84%
- CAS No.: 881-95-8
- Formula: C10H16ClNO3
- Molecular Weight:233.69
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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SULT1
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Metanephrine hydrochloride inhibits MPP+ uptake into Caki-1 cells and rat hepatocytes with IC50s of 34.2 μM and 302.0 μM, respectively[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 881-95-8
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Appearance Solid
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Molecular Weight 233.69
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Formula C10H16ClNO3
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Color White to off-white
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SMILES
CNCC(O)C1=CC(OC)=C(O)C=C1.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : ≥ 100 mg/mL (427.92 mM)
DMSO : 50 mg/mL (213.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Eisenhofer G, et al. Measurements of plasma methoxytyramine, normetanephrine, and metanephrine as discriminators of different hereditary forms of pheochromocytoma. Clin Chem. 2011 Mar;57(3):411-20. [Content Brief]
[2]. Martel F, et al. Comparison between uptake2 and rOCT1: effects of catecholamines, metanephrines and corticosterone. Naunyn Schmiedebergs Arch Pharmacol. 1999 Apr;359(4):303-9. [Content Brief]
[3]. Grouzmann E, et al. Lack of enantioselectivity in the SULT1A3-catalyzed sulfoconjugation of normetanephrine enantiomers: an in vitro and computational study. Chirality. 2013;25(1):28-34. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 4.2792 mL | 21.3959 mL | 42.7917 mL | 106.9793 mL |
| 5 mM | 0.8558 mL | 4.2792 mL | 8.5583 mL | 21.3959 mL | |
| 10 mM | 0.4279 mL | 2.1396 mL | 4.2792 mL | 10.6979 mL | |
| 15 mM | 0.2853 mL | 1.4264 mL | 2.8528 mL | 7.1320 mL | |
| 20 mM | 0.2140 mL | 1.0698 mL | 2.1396 mL | 5.3490 mL | |
| 25 mM | 0.1712 mL | 0.8558 mL | 1.7117 mL | 4.2792 mL | |
| 30 mM | 0.1426 mL | 0.7132 mL | 1.4264 mL | 3.5660 mL | |
| 40 mM | 0.1070 mL | 0.5349 mL | 1.0698 mL | 2.6745 mL | |
| 50 mM | 0.0856 mL | 0.4279 mL | 0.8558 mL | 2.1396 mL | |
| 60 mM | 0.0713 mL | 0.3566 mL | 0.7132 mL | 1.7830 mL | |
| 80 mM | 0.0535 mL | 0.2674 mL | 0.5349 mL | 1.3372 mL | |
| 100 mM | 0.0428 mL | 0.2140 mL | 0.4279 mL | 1.0698 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
(Rac)-Metanephrine hydrochloride Related Classifications
HY-W012206 Related Classifications
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