881-95-8
881-95-8
Chemical Structure
(Rac)-Metanephrine hydrochloride
- CAS. Nr.: 881-95-8
- Formula:C10H16ClNO3
- Molecular Weight:233.69
IUPAC Name: 4-(1-hydroxy-2-(methylamino)ethyl)-2-methoxyphenol hydrochloride
InChIKey: HRIQFVCFOPJYEQ-UHFFFAOYSA-N
SMILES: CNCC(O)C1=CC(OC)=C(O)C=C1.Cl
Biological Activity: (Rac)-Metanephrine hydrochloride is a metabolite of epinephrine and a substrate of the sulfotransferase SULT1A3. (Rac)-Metanephrine hydrochloride undergoes sulfonation at its p-hydroxyl group via a reaction catalyzed by SULT1A3. (Rac)-Metanephrine hydrochloride is an isomer of Metanephrine (HY-113299) hydrochloride, and it is applicable to the research of pheochromocytoma[1][2][3].
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(Rac)-Metanephrine hydrochloride | 99.84% | (Rac)-Metanephrine hydrochloride is a metabolite of epinephrine and a substrate of the sulfotransferase SULT1A3. (Rac)-Metanephrine hydrochloride undergoes sulfonation at its p-hydroxyl group via a reaction catalyzed by SULT1A3. (Rac)-Metanephrine hydrochloride is an isomer of Metanephrine (HY-113299) hydrochloride, and it is applicable to the research of pheochromocytoma. | ||||||||||||||||||||
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DL-Metanephrine hydrochloride (a,b,b-d3, 98%) | 99.34% | DL-Metanephrine (hydrochloride) (a,b,b-d3, 98%) is the deuterium labeled DL-Metanephrine (hydrochloride) (a,b,b, 98%). | ||||||||||||||||||||
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(rac)-Metanephrine-d3 hydrochloride | 99.37% | (rac)-Metanephrine-d3 (hydrochloride) is the deuterium labeled (rac)-Metanephrine hydrochloride. | ||||||||||||||||||||
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References
- [1]. Eisenhofer G, et al. Measurements of plasma methoxytyramine, normetanephrine, and metanephrine as discriminators of different hereditary forms of pheochromocytoma. Clin Chem. 2011 Mar;57(3):411-20. [Content Brief]
- [2]. Martel F, et al. Comparison between uptake2 and rOCT1: effects of catecholamines, metanephrines and corticosterone. Naunyn Schmiedebergs Arch Pharmacol. 1999 Apr;359(4):303-9. [Content Brief]
- [3]. Grouzmann E, et al. Lack of enantioselectivity in the SULT1A3-catalyzed sulfoconjugation of normetanephrine enantiomers: an in vitro and computational study. Chirality. 2013;25(1):28-34. [Content Brief]
