2-Phenyl-1-octen-7-yn-1-one 

2-Phenyl-1-octen-7-yn-1-one is an alkyne-functionalized enone with site-selective reactivity toward the N-terminal α-amino group of peptides and proteins. 2-Phenyl-1-octen-7-yn-1-one can undergo click chemistry with azides via its alkyne moiety to enable further protein functionalization. 2-Phenyl-1-octen-7-yn-1-one modifies unprotected peptide libraries as well as proteins including insulin, lysozyme, RNaseA and BCArg^[1].

2-Phenyl-1-octen-7-yn-1-one (Compound 1) can undergo click chemistry with azide compounds via its alkynyl group to enable further protein functionalization, and it can modify unprotected peptide libraries as well as proteins such as insulin, lysozyme, RNaseA and BCArg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

198.27

C₁₄H₁₄O

1356409-07-8

O=C=C(C=1C=CC=CC1)CCCCC#C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Chan AO, et al. Modification of N-terminal α-amino groups of peptides and proteins using ketenes. J Am Chem Soc. 2012;134(5):2589-2598.  [Content Brief]