DMPE-PEG5000-COOH 

DMPE-PEG5000-COOH is a conjugate composed of DMPE, a PEG chain, and a terminal carboxyl group (-COOH). The carboxyl group in DMPE-PEG5000-COOH can form an amide bond with a primary amine via EDC/NHS activation, enabling targeted modification of liposomes/nanoparticles.

The structure of DMPE-PEG-COOH comprises three key components that work synergistically:
DMPE: Acts as a hydrophobic anchor, securely embedding the entire molecule into the membrane structure of lipid nanoparticles.
PEG chain: Acts as a hydrophilic spacer, forming a hydration layer on the particle surface, reducing non-specific adsorption and immune system clearance, thus prolonging the carrier's circulation time in vivo.
COOH (carboxyl group): A reaction interface located at the end of the PEG chain, it can covalently link with molecules containing amino or hydroxyl groups (such as antibodies, peptides, and fluorescent dyes) through efficient chemical reactions such as amidation and esterification, achieving targeting or tracking functions.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CCCCCCCCCCCCCC(OC[C@@H](OC(CCCCCCCCCCCCC)=O)COP(OCCNC(OCCOCC(O)=O)=O)(O)=O)=O.[n]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.