NH2-PEG4-Val-Cit-PAB-OH

Cat. No.: HY-W800619 Purity: 99.35%: Data Sheet
COA

SDS
Handling Instructions
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NH2-PEG4-Val-Cit-PAB-OH is a cleavable ADC linker featuring a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The primary amine is free to perform a wide variety of reactions such as coupling with carboxylic acids, reductive aminations with ketones or aldehydes, or other more specialized uses such as in SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery via an elimination mechanism within the PAB structure.

For research use only. We do not sell to patients.

NH2-PEG4-Val-Cit-PAB-OH Chemical Structure

CAS No. : 2055024-61-6

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

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View All Isoforms

Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

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Description

Molecular Weight

626.74

Formula

C₂₉H₅₀N₆O₉

CAS No.

2055024-61-6

Appearance

Oil

Color

Colorless to light yellow

SMILES

NCCOCCOCCOCCOCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(C=C1)CO)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (79.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5956 mL	7.9778 mL	15.9556 mL
5 mM	0.3191 mL	1.5956 mL	3.1911 mL
10 mM	0.1596 mL	0.7978 mL	1.5956 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.35%

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Data Sheet (239 KB) SDS (252 KB)

COA (243 KB) HNMR (336 KB) LCMS (102 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.5956 mL	7.9778 mL	15.9556 mL	39.8889 mL
	5 mM	0.3191 mL	1.5956 mL	3.1911 mL	7.9778 mL
	10 mM	0.1596 mL	0.7978 mL	1.5956 mL	3.9889 mL
	15 mM	0.1064 mL	0.5319 mL	1.0637 mL	2.6593 mL
	20 mM	0.0798 mL	0.3989 mL	0.7978 mL	1.9944 mL
	25 mM	0.0638 mL	0.3191 mL	0.6382 mL	1.5956 mL
	30 mM	0.0532 mL	0.2659 mL	0.5319 mL	1.3296 mL
	40 mM	0.0399 mL	0.1994 mL	0.3989 mL	0.9972 mL
	50 mM	0.0319 mL	0.1596 mL	0.3191 mL	0.7978 mL
	60 mM	0.0266 mL	0.1330 mL	0.2659 mL	0.6648 mL