NH2-PEG4-Val-Cit-PAB-OH
Based on 1 Customer Validation
NH2-PEG4-Val-Cit-PAB-OH is a cleavable ADC linker featuring a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The primary amine is free to perform a wide variety of reactions such as coupling with carboxylic acids, reductive aminations with ketones or aldehydes, or other more specialized uses such as in SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery via an elimination mechanism within the PAB structure.
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- Pureté: 99.35%
- CAS No.: 2055024-61-6
- Formule: C29H50N6O9
- Masse moléculaire:626.74
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Stockage:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
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Help & FAQs
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Activité biologique
Chemical Information
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CAS No. 2055024-61-6
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Appearance Oil
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Masse moléculaire 626.74
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Formule C29H50N6O9
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Color Colorless to light yellow
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SMILES
NCCOCCOCCOCCOCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(C=C1)CO)=O)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 50 mg/mL (79.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (239 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5956 mL | 7.9778 mL | 15.9556 mL | 39.8889 mL |
| 5 mM | 0.3191 mL | 1.5956 mL | 3.1911 mL | 7.9778 mL | |
| 10 mM | 0.1596 mL | 0.7978 mL | 1.5956 mL | 3.9889 mL | |
| 15 mM | 0.1064 mL | 0.5319 mL | 1.0637 mL | 2.6593 mL | |
| 20 mM | 0.0798 mL | 0.3989 mL | 0.7978 mL | 1.9944 mL | |
| 25 mM | 0.0638 mL | 0.3191 mL | 0.6382 mL | 1.5956 mL | |
| 30 mM | 0.0532 mL | 0.2659 mL | 0.5319 mL | 1.3296 mL | |
| 40 mM | 0.0399 mL | 0.1994 mL | 0.3989 mL | 0.9972 mL | |
| 50 mM | 0.0319 mL | 0.1596 mL | 0.3191 mL | 0.7978 mL | |
| 60 mM | 0.0266 mL | 0.1330 mL | 0.2659 mL | 0.6648 mL |
NH2-PEG4-Val-Cit-PAB-OH Related Classifications
HY-W800619 Related Classifications
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