1,10-Bis(pyridinium)decane
Based on 1 Customer Validation
1,10-Bis(pyridinium)decane (Decamethylenebispyridinium dibromide) is an acetylcholinesterase (AChE) inhibitor with an IC50 of 25.8 nM. 1,10-Bis(pyridinium)decane acts as a bis-quaternary ligand that bridges the enzyme's catalytic site and peripheral site via its two pyridinium groups. 1,10-Bis(pyridinium)decane can be used for the research of alzheimer's disease.
For research use only. We do not sell to patients.
- Purity: 99.66%
- CAS No.: 6266-40-6
- Formula: C20H30Br2N2
- Molecular Weight:458.27
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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AChE 25.8 nM (IC50) |
1,10-Bis(pyridinium)decane (Decamethylenebispyridinium dibromide) (0-5 nM) inhibits purified acetylcholinesterase from Torpedo marmorata with an IC50 of 25.8 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 6266-40-6
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Appearance Solid
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Molecular Weight 458.27
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Formula C20H30Br2N2
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Color White to off-white
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SMILES
[N+]1(CCCCCCCCCC[N+]2=CC=CC=C2)=CC=CC=C1.[Br-].[Br-]
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Synonyms
Decamethylenebispyridinium dibromide
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : 175 mg/mL (381.87 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (267 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 2.1821 mL | 10.9106 mL | 21.8212 mL | 54.5530 mL |
| 5 mM | 0.4364 mL | 2.1821 mL | 4.3642 mL | 10.9106 mL | |
| 10 mM | 0.2182 mL | 1.0911 mL | 2.1821 mL | 5.4553 mL | |
| 15 mM | 0.1455 mL | 0.7274 mL | 1.4547 mL | 3.6369 mL | |
| 20 mM | 0.1091 mL | 0.5455 mL | 1.0911 mL | 2.7276 mL | |
| 25 mM | 0.0873 mL | 0.4364 mL | 0.8728 mL | 2.1821 mL | |
| 30 mM | 0.0727 mL | 0.3637 mL | 0.7274 mL | 1.8184 mL | |
| 40 mM | 0.0546 mL | 0.2728 mL | 0.5455 mL | 1.3638 mL | |
| 50 mM | 0.0436 mL | 0.2182 mL | 0.4364 mL | 1.0911 mL | |
| 60 mM | 0.0364 mL | 0.1818 mL | 0.3637 mL | 0.9092 mL | |
| 80 mM | 0.0273 mL | 0.1364 mL | 0.2728 mL | 0.6819 mL | |
| 100 mM | 0.0218 mL | 0.1091 mL | 0.2182 mL | 0.5455 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
1,10-Bis(pyridinium)decane Related Classifications
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