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  4. Isatoic anhydride

Isatoic anhydride is a single-adduct forming reagent and a monofunctional SHAPE reagent. Isatoic anhydride reacts with the 2'-hydroxyl group of RNA nucleotides via a single reactive group to form a single adduct, without forming cross-links between nucleotides. In SHAPE-JuMP experiments, Isatoic anhydride serves as a control reagent for single-adduct formation, which is used to distinguish true cross-links from single-adduct formation.

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Isatoic anhydride

Isatoic anhydride Chemical Structure

CAS No. : 118-48-9

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Isatoic anhydride Related Antibodies

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Description

Isatoic anhydride is a single-adduct forming reagent and a monofunctional SHAPE reagent. Isatoic anhydride reacts with the 2'-hydroxyl group of RNA nucleotides via a single reactive group to form a single adduct, without forming cross-links between nucleotides. In SHAPE-JuMP experiments, Isatoic anhydride serves as a control reagent for single-adduct formation, which is used to distinguish true cross-links from single-adduct formation[1].

In Vitro

Isatoic anhydride (incubated for 15-30 min) forms monoadducts exclusively with the catalytic domain RNA of RNase P and VS ribozyme RNA[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Isatoic anhydride Related Antibodies
Molecular Weight

163.13

Formula

C8H5NO3
CAS No.
Appearance

Solid

Color

Light brown to gray

SMILES

O=C1OC(C2=C(N1)C=CC=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
Purity & Documentation

Purity: 99.26%

SDS (393 KB)

COA (253 KB) HNMR (111 KB) RP-HPLC (242 KB)

Handling Instructions (2659 KB)
References
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Isatoic anhydride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isatoic anhydride118-48-9Drug IntermediateDrug IintermediateRT-C8 polymeraseRNA nucleotidesVS ribozyme RNARNase P catalytic domain RNASHAPE-JuMP experimentsInhibitorinhibitorinhibit

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