1. PROTAC
  2. Ligand for Target Protein for PROTAC
  3. Palbociclib-propargyl

Palbociclib-propargyl (Synonyms: PROTAC CDK6 ligand 1)

Cat. No.: HY-130296 Purity: 95.05%
Handling Instructions

Palbociclib-propargyl is a ligand for target protein CDK6 for PROTAC, and binds to CRBN ligand via a PEG linker to make a PROTAC CP-10. CP-10 shows a DC50 of 2.1 nM for CDK6.

For research use only. We do not sell to patients.

Palbociclib-propargyl Chemical Structure

Palbociclib-propargyl Chemical Structure

CAS No. : 2366269-23-8

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Estimated Time of Arrival: December 31
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Description

Palbociclib-propargyl is a ligand for target protein CDK6 for PROTAC, and binds to CRBN ligand via a PEG linker to make a PROTAC CP-10. CP-10 shows a DC50 of 2.1 nM for CDK6[1].

Molecular Weight

485.58

Formula

C₂₇H₃₁N₇O₂

CAS No.

2366269-23-8

SMILES

O=C1C(C(C)=O)=C(C)C2=CN=C(NC3=NC=C(N4CCN(CC#C)CC4)C=C3)N=C2N1C5CCCC5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

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Keywords:

Palbociclib-propargylPROTAC CDK6 ligand 1Ligand for Target Protein for PROTACTarget Protein-binding MoietyInhibitorinhibitorinhibit

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Palbociclib-propargyl
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