2366269-23-8
Chemical Structure
Palbociclib-propargyl
Synonym(s): PROTAC CDK6 ligand 1
- CAS No.: 2366269-23-8
- Formula:C27H31N7O2
- Molecular Weight:485.58
IUPAC Name: 6-acetyl-8-cyclopentyl-5-methyl-2-((5-(4-(prop-2-yn-1-yl)piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one
InChIKey: SLFZXPQZLOODKL-UHFFFAOYSA-N
SMILES: O=C1C(C(C)=O)=C(C)C2=CN=C(NC3=NC=C(N4CCN(CC#C)CC4)C=C3)N=C2N1C5CCCC5
Biological Activity: Palbociclib-propargyl is a ligand for target protein CDK6 for PROTAC, and binds to CRBN ligand via a PEG linker to make a PROTAC CP-10. CP-10 shows a DC50 of 2.1 nM for CDK6[1]. Palbociclib-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Palbociclib-propargyl | 96.12% | Palbociclib-propargyl is a ligand for target protein CDK6 for PROTAC, and binds to CRBN ligand via a PEG linker to make a PROTAC CP-10. CP-10 shows a DC50 of 2.1 nM for CDK6. Palbociclib-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | ||||||||||||||||||||
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