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initiator

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179

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3

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35

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15

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1

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10

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6

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2

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4

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-13992
    AP20187
    Maximum Cited Publications
    48 Publications Verification

    B/B Homodimerizer

    		 FKBP Metabolic Disease
    AP20187 (B/B Homodimerizer) is a cell-permeable ligand used to dimerize FK506-binding protein (FKBP) fusion proteins and initiate biological signaling cascades and gene expression or disrupt protein-protein interactions.
    AP20187
  • HY-150042
    TDI-011536
    3 Publications Verification

    		 Large Tumor Suppressor (LATS) YAP Cardiovascular Disease Others
    TDI-011536 is a potent Lats kinase inhibitor, interrupts Hippo-Yap signaling and initiates the proliferation of lesioned heartmuscle cells. TDI-011536 can be used in studies of organ conservation and regeneration .
    TDI-011536
  • HY-115670
    GW280264X
    5+ Cited Publications

    		 MMP Inflammation/Immunology Cancer
    GW280264X is the mixed ADAM10/TACE (ADAM17) metalloproteinases inhibitor. GW280264X potently blocks TACE (ADAM17) and ADAM10 with IC50s of 8.0 nM and 11.5 nM, respectively . ADAM10 and 17 modulate the immunogenicity of glioblastoma-initiating cells .
    GW280264X
  • HY-125857C
    Cytochrome C (bovine heart)

    		Biochemical Assay Reagents Apoptosis Reactive Oxygen Species (ROS) Caspase Metabolic Disease
    Cytochrome C (bovine heart) is composed of 104 amino acids and is a nuclear-encoded mitochondrial protein. Cytochrome C (bovine heart) acts as an effective ROS scavenger, but when combined with the cofactor p66Shc, it promotes the generation of ROS to initiate apoptosis. Cytochrome C (bovine heart) can act as a single electron carrier .
    Cytochrome C (bovine heart)
  • HY-121320
    Raptinal
    5+ Cited Publications

    		 Caspase Apoptosis Cancer
    Raptinal, a agent that directly activates caspase-3, initiates intrinsic pathway caspase-dependent apoptosis. Raptinal is able to rapidly induce cancer cell death by directly activating the effector caspase-3, bypassing the activation of initiator caspase-8 and caspase-9 .
    Raptinal
  • HY-Y0525
    AAPH
    2 Publications Verification

    2,2'-Azodiisobutyramidine dihydrochloride

    		 Reactive Oxygen Species (ROS) Inflammation/Immunology
    AAPH (2,2'-Azodiisobutyramidine dihydrochloride) has an effect of radical generation. AAPH induces oxidative stress and erythrocyte hemolysis . AAPH decomposes at 37°C to generate an alkyl radical, is used as an initiator. In the presence of oxygen, these alkyl radicals will be converted to peroxyl radicals that can cause lipid peroxidation and loss of erythrocyte membrane integrity, which could ultimately lead to hemolysis .
    AAPH
  • HY-P99742
    Mitazalimab
    1 Publications Verification

    ADC-1013; JNJ-64457107; Vanalimab

    		 TNF Receptor Cancer
    Mitazalimab (ADC-1013; JNJ-64457107) is FcγR-dependent CD40 agonist with tumor-directed activity. Mitazalimab activates antigen-presenting cells, e.g. dendritic cells (DC), to initiate tumor-reactive T cells. Therefore, Mitazalimab induces tumor-specific T cells to infiltrate and kill tumors. Mitazalimab remodels the tumor-infiltrating myeloid microenvironment .
    Mitazalimab
  • HY-15888
    PTC-209
    15+ Cited Publications

    		 BMI1 Autophagy Cancer
    PTC-209 is a specific BMI-1 inhibitor with an IC50 of 0.5 μM in HEK293T cell line. PTC-209 irreversibly impairs colorectal cancer-initiating cells (CICs). PTC-209 shows potent anti-myeloma activity and impairs the tumor microenvironment .
    PTC-209
  • HY-158712
    3'-ONH2-dATP sodium solution (100 mM)

    		Others
    3'-ONH2-dATP (sodium) solution (100 mM) is a 3'-O-blocked reversible terminator deoxynucleotide triphosphate.3'-ONH2-dATP (sodium) solution (100 mM) stops DNA polymerization after single-nucleotide addition to an initiator strand, and its 3'-ONH2 blocking group can be removed to restore a free 3'-OH for subsequent extension.3'-ONH2-dATP (sodium) solution (100 mM) incorporates into an oligonucleotide chain by engineered terminal deoxynucleotidyl transferase from Zonotrichia albicollis to enable template-free, stepwise de novo enzymatic DNA synthesis .
    3'-ONH2-dATP sodium solution (100 mM)
  • HY-N6641
    Monascin
    2 Publications Verification

    		 Keap1-Nrf2 PPAR Inflammation/Immunology Cancer
    Monascin is a kind of azaphilonoid pigments extracted from Monascus pilosus-fermented rice (red-mold rice). Monascin also exhibits anti-tumor-initiating activity and anti-inflammatory activity with oral administration. Monascin inhibits the activation of NOR 1 (an NO donor). Monascin is a Nrf2 activator and PPARγ agonist .
    Monascin
  • HY-164008
    DTUN

    		Ferroptosis Others
    DTUN is a lipophilic hyponitrite radical initiator and can initiates lipid peroxidation. DTUN is a tool for research of ferroptosis .
    DTUN
  • HY-W004761
    Tetrahydroxydiboron

    Hypodiboric acid

    		 Bacterial Reactive Oxygen Species (ROS) Infection Inflammation/Immunology
    Tetrahydroxydiboron (Hypodiboric acid) acts as a hydrogel initiator and bioadhesion promoter, with broad-spectrum antibacterial activity, ROS scavenging capacity, and osteogenic induction properties. Tetrahydroxydiboron initiates rapid gelation by generating free radicals through reactions with vinyl monomers and dissolved oxygen, overcoming oxygen inhibition without deoxygenation or external triggers. Tetrahydroxydiboron achieves strong bioadhesion via interaction with carboxymethyl chitosan. Tetrahydroxydiboron can be used in the research of periodontitis and related inflammatory diseases .
    Tetrahydroxydiboron
  • HY-112484
    RS-246204
    2 Publications Verification

    		 Organoid Cancer
    RS-246204 is a R-spondin-1 substitute compound that is able initiate small intestinal organoids without the use of the R-spondin-1 protein.
    RS-246204
  • HY-P4808
    PHF6

    		Amyloid-β Autophagy Neurological Disease
    PHF6 (VQIVYK) is a self-assembly sequence capable of initiating the full-length tau protein aggregation and is mapped to the third microtubule-binding repeat region of the tau protein .
    PHF6
  • HY-W783268A
    Matriptase-IN-2

    		Ser/Thr Protease Inflammation/Immunology
    Matriptase-IN-2 is a secondary amide inhibitor of matriptase derived from sulfonylated 3-amidinophenylalanine, with a Ki value of 5 nM. Matriptase acts as a novel initiator of cartilage matrix degradation in osteoarthritis, and Matriptase-IN-2 inhibits matriptase-mediated cartilage degradation. Matriptase-IN-2 is applicable for the research of osteoarthritis .
    Matriptase-IN-2
  • HY-162065
    N6F11
    1 Publications Verification

    		 Ferroptosis Cancer
    N6F11 is a selective ferroptosis inducer, and can selectively induce ferroptosis by targeting TRIM25-mediated GPX4 degradation in cancer cells while sparing immune cells. N6F11 initiates HMGB1-dependent antitumor immunity mediated by CD8 + T cells .
    N6F11
  • HY-134928
    Pyridinium bisretinoid A2E

    A2E

    		 Apoptosis Autophagy Reactive Oxygen Species (ROS) Cancer
    Pyridinium bisretinoid A2E (A2E) is a fluorophore that can be isolated from lipofuscin in the retinal pigment epithelium (RPE). Pyridinium bisretinoid A2E is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E mediates autophagy and the production of reactive oxygen species. Pyridinium bisretinoid A2E can be used in the study of retinal degenerative diseases .
    Pyridinium bisretinoid A2E
  • HY-116544
    Octan-2-yl 2-cyanoacrylate

    		Biochemical Assay Reagents Others
    Octan-2-yl 2-cyanoacrylate is an alkyl cyanoacrylate monomer, base-sensitive monofunctional 1,1-disubstituted electron-deficient olefin, polymerizable and copolymerizable monomer. Octan-2-yl 2-cyanoacrylate undergoes homopolymerization via nucleophilic initiation with pyridine as initiator. Octan-2-yl 2-cyanoacrylate forms true copolymers with ethyl 2-cyanoacrylate via nucleophilic initiation with pyridine as initiator .
    Octan-2-yl 2-cyanoacrylate
  • HY-E70094
    T4 UvsX Recombinase

    		DNA/RNA Synthesis Others
    T4 UvsX Recombinase helps initiate DNA replication on a double-stranded DNA template by catalyzing synapsis between the template and a homologous DNA single strand that serves as primer. T4 UvsX Recombinase greatly amplifies the snap-back (hairpin-primed) DNA synthesis that is catalyzed by the T4 DNA polymerase holoenzyme on linear, single-stranded DNA templates .
    T4 UvsX Recombinase
  • HY-W016618
    Ethyl phenylglyoxylate

    Ethyl benzoylformate; Phenylglyoxylic acid ethyl ester

    		 Drug Intermediate Biochemical Assay Reagents Carboxylesterase (CES) Others
    Ethyl phenylglyoxylate (Ethyl benzoylformate), the ethyl ester of phenylglyoxylic acid, is used as a synthetic reagent. Ethyl phenylglyoxylate is also a poor substrate but a potent inhibitor of chicken liver carboxylesterase. Additionally, Ethyl phenylglyoxylate exhibits photoreactivity, where its excited triplet carbonyl can initiate intermolecular hydrogen abstraction, radical coupling and cross-linking reactions .
    Ethyl phenylglyoxylate
  • HY-75800
    Lomibuvir
    2 Publications Verification

    VX-222

    		 DNA/RNA Synthesis HCV Infection
    Lomibuvir (VX-222), a selective, non-nucleoside polymerase inhibitor, targets thumb pocket 2 of the HCV NS5B polymerase (RdRp) with a Kd of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC50 of 5.2 nM. Lomibuvir preferentially inhibits elongative RNA synthesis rather than de novo-initiated RNA synthesis .
    Lomibuvir
  • HY-W087905
    2,3-Dimethyl-2,3-diphenylbutane

    		Biochemical Assay Reagents Others
    2,3-Dimethyl-2,3-diphenylbutane is a minor product formed during the thermal decomposition of dicumyl peroxide (DCP) in cumene, generated through radical coupling reactions. As an initiator capable of producing free radicals, 2,3-dimethyl-2,3-diphenylbutane promotes cross-linking or decomposition processes via initiating free radical reactions in fields such as polymer polymerization (e.g., modification of polyphenylene oxide processing), organic synthesis (e.g., DCP decomposition reactions), and coal processing (e.g., oxidation stabilization of coal tar pitch), thereby enhancing material properties or reaction efficiency .
    2,3-Dimethyl-2,3-diphenylbutane
  • HY-124867
    D3-βArr

    		TSH Receptor Endocrinology
    D3-βArr is a positive allosteric modulator for thyrotropin receptor (TSHR), which initiates translocation of β-Arr 1 by direct TSHR activation and potentiates TSH-mediated preosteoblast differentiation in vitro .
    D3-βArr
  • HY-126316
    Zapalog
    1 Publications Verification

    		 FKBP Others
    Zapalog is a photocleavable small-molecule heterodimerizer that can be used to repeatedly initiate, and instantaneously terminate, a physical interaction between two target proteins. Zapalog dimerizes any two proteins tagged with the FKBP and DHFR domains until exposure to light causes its photolysis .
    Zapalog
  • HY-106275
    FX-06

    Fibrin-derived peptide Bβ15-42

    		 Flavivirus Dengue Virus Cardiovascular Disease
    FX-06 (Fibrin-derived peptide Bβ15-42) is a fibrin Bbeta chain-derived peptide. FX-06 binds to VE-cadherin and inhibits leukocyte transmigration and initiates VE-cadherin-mediated signaling. FX-06 can be used in the research of ischemia/reperfusion injury, Dengue shock syndrome (DSS) .
    FX-06
  • HY-W015987
    9-Fluorenylmethyl carbamate

    Fmoc-NH2

    		 Biochemical Assay Reagents Others
    9-Fluorenylmethyl carbamate (Fmoc-NH2) is an amide compound with an Fmoc protecting group, which can be used as a photobase initiator to prepare organosilane-based proton exchange membranes .
    9-Fluorenylmethyl carbamate
  • HY-P4808A
    PHF6 TFA

    		Amyloid-β Autophagy Neurological Disease
    PHF6 (VQIVYK) TFA is a self-assembly sequence capable of initiating the full-length tau protein aggregation. PHF6 TFA is mapped to the third microtubule-binding repeat region of the tau protein .
    PHF6 TFA
  • HY-15888A
    PTC-209 hydrobromide
    15+ Cited Publications

    		 BMI1 Autophagy Cancer
    PTC-209 hydrobromide is a specific BMI-1 inhibitor with an IC50 of 0.5 μM in HEK293T cell line. PTC-209 hydrobromide irreversibly impairs colorectal cancer-initiating cells (CICs). PTC-209 hydrobromide shows potent anti-myeloma activity and impairs the tumor microenvironment .
    PTC-209 hydrobromide
  • HY-P2948
    Protein serine/threonine kinase

    Ser/Thr protein kinase

    		 Biochemical Assay Reagents Infection
    Protein serine/threonine kinase is a type of serine/threonine protein kinase. Protein serine/threonine kinases are pleiotropic signaling proteins that can phosphorylate various substrates, thereby initiating branched signaling pathways. Mycobacteria protein serine/threonine kinase plays a crucial role in signal transduction pathways, ultimately determining the growth and metabolic adaptability of mycobacteria .
    Protein serine/threonine kinase
  • HY-134928AS
    Pyridinium bisretinoid A2E-d4 TFA

    A2E-d4 TFA

    		 Isotope-Labeled Compounds Cancer
    Pyridinium bisretinoid A2E-d4 TFA is the deuterium-labeled Pyridinium bisretinoid A2E (HY-134928). Pyridinium bisretinoid A2E (A2E)is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E mediates autophagy and the production of reactive oxygen species .
    Pyridinium bisretinoid A2E-d4 TFA
  • HY-124426
    Triethyl aconitate

    		Biochemical Assay Reagents Others
    Triethyl aconitate can undergo copolymerization with butadiene and styrene. Triethyl aconitate is reactive in free radical initiated copolymerizations .
    Triethyl aconitate
  • HY-NP170
    Holo Transferrin (Bovine)

    HTF (Bovine)

    		 Biochemical Assay Reagents Metabolic Disease
    Holo Transferrin (Bovine) (HTF (Bovine)) is a glycoprotein that acts as a growth factor. Binding of Holo Transferrin (Bovine) to its receptor is necessary for cells to initiate and maintain their DNA synthesis .
    Holo Transferrin (Bovine)
  • HY-167709
    Azacosterol

    20.25-Diazacholesterol

    		 Xanthine Oxidase Neurological Disease
    Azacosterol (20.25-Diazacholesterol), also known as Diazasterol, acts as a DHCR24 inhibitor and initiates a cascade of reactions in cortical neurons after being administered orally or via intraperitoneal injection.
    Azacosterol
  • HY-P11048
    Thrombin-cleavable peptide

    		Thrombin Cardiovascular Disease Neurological Disease
    Thrombin-cleavable peptide is a type of peptide that can be recognized and cleaved by thrombin. After cleavage, Thrombin-cleavable peptide releases thrombolytic peptides to initiate thrombolysis. Thrombin-cleavable peptide can be used in the research of diseases such as ischemic stroke .
    Thrombin-cleavable peptide
  • HY-P2145
    Extracellular death factor

    EDF

    		 Bacterial Infection
    Extracellular death factor (EDF) is the only single signaling molecule involved in Escherichia coli quorum sensing, and can initiate MAZEF-mediated cell death. Extracellular death factor significantly amplifies the endoribonucleolytic activities of both MazF and ChpBK .
    Extracellular death factor
  • HY-403874
    2-Br-2,2-Dimethyl-acetamido-NHS ester

    		Biochemical Assay Reagents Others
    2-Br-2,2-Dimethyl-acetamido-NHS ester (compound II) is a functionalized amide-containing initiator .
    2-Br-2,2-Dimethyl-acetamido-NHS ester
  • HY-D1453
    Immune initiator-1

    		Biochemical Assay Reagents Cancer
    Immune initiator-1 (Compound 1a) is an amino acid-modified near-infrared Aza-BODIPY photosensitizer, acts as an immune initiator for potent photodynamic research in melanoma .
    Immune initiator-1
  • HY-Y1356
    2,4-Dimethoxybenzaldehyde

    		Biochemical Assay Reagents Cancer
    2,4-Dimethoxybenzaldehyde is a tumor initiator with genotoxic property. 2,4-Dimethoxybenzaldehyde can induce benign papilloma development and converse to squamous cell carcinoma in the skin of susceptible mouse models. 2,4-Dimethoxybenzaldehyde can be used for skin cancer research .
    2,4-Dimethoxybenzaldehyde
  • HY-163121
    PST3.1a

    		Glycosyltransferase TGF-β Receptor FAK Galectin Collagen Endocrinology Cancer
    PST3.1a is an orally active and brain-penetrant N-acetylglucosamine glycosyltransferase (MGAT5) inhibitor with a human IC50 of 2 µM. PST3.1a inhibits TGFβR and FAK signaling pathway activity. PST3.1a alters β1,6-GlcNAc N-glycans and microtubule/microfilament integrity, increases OLIG2 expression, and inhibits proliferation, migration, invasiveness, and clonogenic capacities of glioblastoma initiating cells. PST3.1a reduces invasive and proliferative capacity of glioblastoma initiating cells in orthotopic graft models, increases overall survival of orthotopic graft model mice. PST3.1a blunts MGAT5 overexpression, decreases renal fibrosis via collagen 1, collagen 4, and galectin 3 downregulation in a rat chronic kidney disease model. PST3.1a can be used for the research of glioblastoma multiforme and chronic kidney disease .
    PST3.1a
  • HY-124052
    AZ-27

    		RSV Infection
    AZ-27 is a respiratory syncytial virus (RSV) inhibitor. AZ-27 can differentially suppress various RSV polymerase activities at the promoter, thereby inhibiting the early stages of mRNA transcription and genome replication by targeting the promoter .
    AZ-27
  • HY-W028108
    Piperonyl alcohol

    		Drug Derivative Others
    Piperonyl alcohol is a benzodioxole derivative. It is biocompatible and can be used in chemical synthesis as an initiator .
    Piperonyl alcohol
  • HY-165152
    KAS 08

    		STING Others
    KAS 08 is an effective STING pathway activator in vitro and in vivo. KAS 08 enhances STING activity initiated by cGAMP.
    KAS 08
  • HY-N12233
    Condurango glycoside A

    		Apoptosis MDM-2/p53 Reactive Oxygen Species (ROS) Cancer
    Condurango glycoside A is an activator of p53. Condurango glycoside A initiates ROS generation and up-regulates p53 expression. Condurango glycoside A induces apoptosis and pre-mature senescence associated with DNA damage in HeLa cells .
    Condurango glycoside A
  • HY-112554
    PDM11

    		Phosphatase Others
    PDM11 is a derivative of antioxidant resveratrol. PDM11 do not exhibit any significant protective effect against oxidation of linoleate micelles initiated by radiolysis-generated hydroxyl radicals. PDM11 is inactive in resveratrol activity assays .
    PDM11
  • HY-138263
    Allyl 2-acetamido-2-deoxy-β-D-glucopyranoside

    		Biochemical Assay Reagents Others
    Allyl 2-acetamido-2-deoxy-β-D-glucopyranoside is a NodC substrate and chitooligosaccharide chain initiator. Allyl 2-acetamido-2-deoxy-β-D-glucopyranoside acts as an initial acceptor to enable the extension of chitooligosaccharide chains and the synthesis of allyl penta-N-acetylchitopentaose .
    Allyl 2-acetamido-2-deoxy-β-D-glucopyranoside
  • HY-156242
    BQZ-485

    		Paraptosis Cancer
    BQZ-485 is a a potent GDI2 inhibitor through the interaction with Tyr245. BQZ-485 disrupts the intrinsic GDI2-Rab1A interaction, thereby abolishing vesicular transport from the endoplasmic reticulum (ER) to the Golgi apparatus and initiating subsequent paraptosis events .
    BQZ-485
  • HY-162344
    Ir-CA

    		Apoptosis Autophagy Cancer
    Ir-CA is an antitumor agent. Ir-CA can accumulate in mitochondria and induces mitochondria dysfunction. Ir-CA induces apoptosis and autophagy. Ir-CA initiates mitophagy and cell cycle arrest to kill Cisplatin (HY-17394)-resistant A549R cells. Ir-CA can effectively inhibit metastasis by inhibiting MMP-2/MMP-9 .
    Ir-CA
  • HY-159850
    CAU

    CpApU

    		 Epigenetic Reader Domain Cancer
    CAU (FCpApU) is an anticodon of the initiator tRNA (tRNAfMet). CAU is the major determinant for aminoacylation of tRNAfMet by MetRS .
    CAU
  • HY-W470415
    Alfalone

    		Microtubule/Tubulin Cancer
    Alfalone (compound 9ia) is an antimitotic agent. Alfalone causes cleavage arrest and initiates the formation of tuberculate eggs .
    Alfalone
  • HY-126573R
    Trilaurin (Standard)

    		Reference Standards Others Cancer
    Trilaurin (Standard) is the analytical standard of Trilaurin. This product is intended for research and analytical applications. Trilaurin could inhibit the formation of neoplasms initiated by dimethylbenzanthracene (DMBA) and promoted by croton oil .
    Trilaurin (Standard)

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