Cytochrome C (bovine heart)

Cat. No.: HY-125857C Purity: 97.9%: Data Sheet
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Cytochrome C (bovine heart) is composed of 104 amino acids and is a nuclear-encoded mitochondrial protein. Cytochrome C (bovine heart) acts as an effective ROS scavenger, but when combined with the cofactor p66Shc, it promotes the generation of ROS to initiate apoptosis. Cytochrome C (bovine heart) can act as a single electron carrier.

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Cytochrome C (bovine heart) Chemical Structure

CAS No. : 9007-43-6

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Description	Cytochrome C (bovine heart) is composed of 104 amino acids and is a nuclear-encoded mitochondrial protein. Cytochrome C (bovine heart) acts as an effective ROS scavenger, but when combined with the cofactor p66Shc, it promotes the generation of ROS to initiate apoptosis. Cytochrome C (bovine heart) can act as a single electron carrier^[1]^[2].
In Vitro	When cytochrome C (bovine heart) is combined with non-specific phosphatase inhibitors (fluorides and vanadates), phosphorylation occurs at the Tyr97 site, resulting in a decrease in its affinity for cytochrome c-oxidase (CcO), thereby partially inhibiting the electron transfer efficiency of the mitochondrial respiratory chain^[1]. Cytochrome C (bovine heart) is released from the intermembrane space of the mitochondria into the cytoplasm when the cell receives an apoptotic signal. In the cytoplasm, it no longer performs its normal respiratory function but instead acts as a crucial apoptotic signaling molecule, binding to apoptotic protease activating factor-1 (APAF-1), initiating the caspase cascade reaction, and ultimately leading to cell apoptosis^[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Cytochrome C (bovine heart) Related Antibodies
CAS No.	9007-43-6
Appearance	Solid
Color	Brown to reddish brown
SMILES	[Cytochrome C (bovine heart)]
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility	In Vitro: H₂O : 100 mg/mL (Need ultrasonic) Molarity Calculator Dilution Calculator Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Mass = Concentration × Volume × Molecular Weight * Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final) This equation is commonly abbreviated as: C₁V₁ = C₂V₂ Concentration _(start) C1 × Volume _(start) V1 = Concentration _(final) C2 × Volume _(final) V2 In Vivo Dissolution Calculator Please enter the basic information of animal experiments: Dosage mg/kg Animal weight (per animal) g Dosing volume (per animal) μL Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments. Calculation results: Working solution concentration: mg/mL This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details. The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE). Tel: 609-228-6898 E-mail: [email protected] Technical Support: [email protected]
Purity & Documentation	Purity: 97.9% Select Batch: Data Sheet (267 KB) SDS (393 KB) COA (230 KB) Handling Instructions (2659 KB)
References	[1]. Hüttemann M, et al. The multiple functions of cytochrome c and their regulation in life and death decisions of the mammalian cell: From respiration to apoptosis. Mitochondrion. 2011 May;11(3):369-81. [Content Brief] [2]. Zou H, et al. An APAF-1· cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. Journal of Biological Chemistry. 1999 Apr 23;274(17):11549-56.