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Cat. No.: HY-125857C

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Cytochrome C (bovine heart)

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Cytochrome C (bovine heart) is composed of 104 amino acids and is a nuclear-encoded mitochondrial protein. Cytochrome C (bovine heart) acts as an effective ROS scavenger, but when combined with the cofactor p66Shc, it promotes the generation of ROS to initiate apoptosis. Cytochrome C (bovine heart) can act as a single electron carrier.

For research use only. We do not sell to patients.

Purity: 97.9%
CAS No.: 9007-43-6

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Cytochrome C (bovine heart) Chemical Structure

CAS No.: 9007-43-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Caspase Isoforms :

In Vitro

When cytochrome C (bovine heart) is combined with non-specific phosphatase inhibitors (fluorides and vanadates), phosphorylation occurs at the Tyr97 site, resulting in a decrease in its affinity for cytochrome c-oxidase (CcO), thereby partially inhibiting the electron transfer efficiency of the mitochondrial respiratory chain^[1].
Cytochrome C (bovine heart) is released from the intermembrane space of the mitochondria into the cytoplasm when the cell receives an apoptotic signal. In the cytoplasm, it no longer performs its normal respiratory function but instead acts as a crucial apoptotic signaling molecule, binding to apoptotic protease activating factor-1 (APAF-1), initiating the caspase cascade reaction, and ultimately leading to cell apoptosis^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 9007-43-6
Appearance Solid
Color Brown to reddish brown
SMILES

[Cytochrome C (bovine heart)]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (Need ultrasonic)

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Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hüttemann M, et al. The multiple functions of cytochrome c and their regulation in life and death decisions of the mammalian cell: From respiration to apoptosis. Mitochondrion. 2011 May;11(3):369-81. [Content Brief]

[2]. Zou H, et al. An APAF-1· cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. Journal of Biological Chemistry. 1999 Apr 23;274(17):11549-56.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References

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Cytochrome C (bovine heart)

All Caspase Isoforms