Casein 

Casein is an orally active phosphoprotein that can be separated into various electrophoretic components, such as α₂-Casein, κ-Casein, β-casein, and γ-casein. Casein has also been blended and grafted with other polymers, cross-linkers, or monomers to improve its functional properties. Casein enhances calcium absorption and reduces the extent of fissure as well as smooth-surface caries. Casein promotes proliferation of prostate cancer. Casein has various applications in the paper, leather, textile, and food industries, serving as coatings, adhesives, and packaging materials^{[1][2][3][4][5][6]}.

Casein (1 mg/mL) promotes proliferation of prostate cancer cells PC3 (166%) and LNCaP (142%)^[2].
Casein (0.2%) supports cell density-dependent growth of Myxococcus xanthus^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Casein (hydrolyzed, 16-32 energy percent protein, diet, p.o.) reduces diet-induced obesity in male C57BL/6J mice^[4].
Casein (500 ppm, p.o., 2 weeks) enhances calcium absorption in the rat^[5].
Casein (2% (w/v), in drinking water, p.o.) reduces the extent of fissure and smooth-surface caries of male Sprague-Dawley rats consuming a solid cariogenic diet^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2061.96

C₈₁H₁₂₅N₂₂O₃₉P

9000-71-9

Solid

Off-white to light yellow

[Casein]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Ghosh A, et al. Effect of cross-linking on microstructure and physical performance of casein protein. Biomacromolecules. 2009;10(7):1681-1688.  [Content Brief]

  [2]. Park SW, et al. A milk protein, casein, as a proliferation promoting factor in prostate cancer cells. World J Mens Health. 2014 Aug;32(2):76-82.  [Content Brief]

  [3]. Rosenberg E, et al. Cell density-dependent growth of Myxococcus xanthus on casein. J Bacteriol. 1977 Feb;129(2):770-7.  [Content Brief]

  [4]. Lillefosse HH, et al. Hydrolyzed casein reduces diet-induced obesity in male C57BL/6J mice. J Nutr. 2013 Sep;143(9):1367-75.  [Content Brief]

  [5]. Bennett T, et al. The effect of high intakes of casein and casein phosphopeptide on calcium absorption in the rat. Br J Nutr. 2000 Jun;83(6):673-80.  [Content Brief]

  [6]. Reynolds EC, et al. Effect of casein and whey-protein solutions on caries experience and feeding patterns of the rat. Arch Oral Biol. 1984;29(11):927-33.  [Content Brief]