Cytochrome C (Saccharomyces cerevisiae)

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Cytochrome C (Saccharomyces cerevisiae) is a type C cytochrome located in the intermembrane space of the mitochondria. As an electron carrier, Cytochrome C (Saccharomyces cerevisiae) transfers electrons between complex III (cytochrome c reductase) and complex IV (cytochrome c oxidase, CIV) of the respiratory chain. Cytochrome C (Saccharomyces cerevisiae) can play a crucial role in triggering apoptosis by being released from the mitochondria into the cytosol.

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Cytochrome C (Saccharomyces cerevisiae) Chemical Structure

CAS No. : 9007-43-6

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Description	Cytochrome C (Saccharomyces cerevisiae) is a type C cytochrome located in the intermembrane space of the mitochondria. As an electron carrier, Cytochrome C (Saccharomyces cerevisiae) transfers electrons between complex III (cytochrome c reductase) and complex IV (cytochrome c oxidase, CIV) of the respiratory chain. Cytochrome C (Saccharomyces cerevisiae) can play a crucial role in triggering apoptosis by being released from the mitochondria into the cytosol^[1]^[2]^[3].
In Vitro	Cytochrome C (Saccharomyces cerevisiae) exhibits a significant enhancement in the enzymatic activity of yeast chain-like complex IV (CIV) when it is modified with phosphorylation mimetic. This indicates that its activity can be regulated by its own phosphorylation status, and this phosphorylation-dependent regulatory function requires the participation of the respiratory supercomplex factor 1 (Rcf1) of the hypoxia-inducible gene domain (HIGD) protein family^[2]. Cytochrome C (Saccharomyces cerevisiae) is released from the intermembrane space of the mitochondria into the cytoplasm when the cell receives an apoptotic signal. In the cytoplasm, it no longer performs its normal respiratory function but instead acts as a crucial apoptotic signaling molecule, binding to apoptotic protease activating factor-1 (APAF-1), initiating the caspase cascade reaction, and ultimately leading to cell apoptosis^[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Cytochrome C (Saccharomyces cerevisiae) Related Antibodies
CAS No.	9007-43-6
SMILES	[Cytochrome C (Saccharomyces cerevisiae)]
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (265 KB) Handling Instructions (2659 KB)
References	[1]. Corvest V, et al. c-type cytochrome assembly in Saccharomyces cerevisiae: a key residue for apocytochrome c1/lyase interaction. Genetics. 2010 Oct;186(2):561-71. [Content Brief] [2]. Timón-Gómez A, et al. HIGD-Driven Regulation of Cytochrome c Oxidase Biogenesis and Function. Cells. 2020 Dec 6;9(12):2620. [Content Brief] [3]. Zou H, et al. An APAF-1· cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. Journal of Biological Chemistry. 1999 Apr 23;274(17):11549-56.