Totrombopag choline
Totrombopag (SB-559448) choline is an orally effective thrombopoietin receptor (TpoR) agonist. By activating TpoR, Totrombopag choline initiates an intracellular signaling cascade mediated by JAK2 kinase and the transcription factor Stat5, a signaling process that is the primary mechanism regulating megakaryocyte growth and differentiation into platelets. Totrombopag choline can be used to study platelet production and megakaryocyte biology.
For research use only. We do not sell to patients.
- CAS No.: 851606-62-7
- Formula: C30H35N9O3
- Molecular Weight:569.66
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Chemical Information
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CAS No. 851606-62-7
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Molecular Weight 569.66
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Formula C30H35N9O3
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SMILES
O=C1N(C2=CC=C(C)C(C)=C2)N=C(C1/N=N/C3=C(O)C(C4=CC(C5=NN=N[N-]5)=CC=C4)=CC=C3)C.OCC[N+](C)(C)C
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Synonyms
SB-559448 choline
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)