2,4-Dimethoxybenzaldehyde
Based on 1 Customer Validation
2,4-Dimethoxybenzaldehyde is a tumor-inducing agent that can be used in combination with TPA (HY-18739) to induce a two-stage skin carcinogenesis model in mice. 2,4-Dimethoxybenzaldehyde has weak antifungal activity and is also a starting material for the synthesis of indolylhydrazone derivatives. 2,4-Dimethoxybenzaldehyde can be used in the study of skin tumorigenesis.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 99.98%
- CAS No.: 613-45-6
- 화학식: C9H10O3
- 분자량:166.17
-
보관:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
용액&용해도
- 순도&문서
- References
-
Help & FAQs
-
HY-N1096
VeratraldehydeAromatic Compound -
HY-N0098
VanillinPhenolic Aldehyde -
HY-N0098R
Vanillin (Standard) -
HY-N1096R
Veratraldehyde (Standard)Synthesis Intermediate -
HY-Y0015
p-DimethylaminobenzaldehydeChromogenic Reagent -
HY-Y0740
4-MethoxybenzaldehydePhenol -
HY-N8015
OctanalAromatic Aldehyde -
HY-W007376
Indole-3-carboxaldehydeEndogenous Metabolite -
HY-W013627
trans,trans-2,4-DecadienalLipid Peroxidation Product -
HY-W020014
Pyruvic aldehyde (40%w/w in water)Cell Stabilizer -
HY-W007376R
Indole-3-carboxaldehyde (Standard)Endogenous Metabolite -
HY-W007539
2,4-DihydroxybenzaldehydeDrug Intermediate
Biological Activity
제품 설명
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:C57BL/6J wild-type controls and keratinocyte-specific ATG16L1 knockout mice(7-8 weeks old)[4]
-
Dosage:100 nmol dissolved in 200 µl acetone
-
Administration:topical application; single administration; seven days later, treated with 6 nmol TPA three times weekly for 15 weeks
-
Result:Combined with TPA successfully induced the formation of skin papillomas in mice.
Compared with control mice, keratinocyte autophagy-deficient (ΔKeratg16l1) mice were more sensitive to 2,4-Dimethoxybenzaldehyde/TPA-induced skin tumorigenesis, developing tumors at an earlier time point and forming a significantly higher number of tumors.
Chemical Information
-
CAS No. 613-45-6
-
Appearance Solid
-
분자량 166.17
-
화학식 C9H10O3
-
Color White to light brown
-
SMILES
O=CC1=CC=C(C=C1OC)OC
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
용액&용해도
In Vitro:
DMSO : 100 mg/mL (601.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (15.04 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (15.04 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
-
Data Sheet (277 KB)
-
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
-
Handling Instructions (2659 KB)
References
[3]. Kim JH, et al. Antifungal activity of redox-active benzaldehydes that target cellular antioxidation. Annals of clinical microbiology and antimicrobials. 2011 May 31;10:23. [Content Brief]
[4]. Van Hove L, et al. Autophagy critically controls skin inflammation and apoptosis-induced stem cell activation. Autophagy. 2023 Nov;19(11):2958-2971. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.0179 mL | 30.0897 mL | 60.1793 mL | 150.4483 mL |
| 5 mM | 1.2036 mL | 6.0179 mL | 12.0359 mL | 30.0897 mL | |
| 10 mM | 0.6018 mL | 3.0090 mL | 6.0179 mL | 15.0448 mL | |
| 15 mM | 0.4012 mL | 2.0060 mL | 4.0120 mL | 10.0299 mL | |
| 20 mM | 0.3009 mL | 1.5045 mL | 3.0090 mL | 7.5224 mL | |
| 25 mM | 0.2407 mL | 1.2036 mL | 2.4072 mL | 6.0179 mL | |
| 30 mM | 0.2006 mL | 1.0030 mL | 2.0060 mL | 5.0149 mL | |
| 40 mM | 0.1504 mL | 0.7522 mL | 1.5045 mL | 3.7612 mL | |
| 50 mM | 0.1204 mL | 0.6018 mL | 1.2036 mL | 3.0090 mL | |
| 60 mM | 0.1003 mL | 0.5015 mL | 1.0030 mL | 2.5075 mL | |
| 80 mM | 0.0752 mL | 0.3761 mL | 0.7522 mL | 1.8806 mL | |
| 100 mM | 0.0602 mL | 0.3009 mL | 0.6018 mL | 1.5045 mL |
2,4-Dimethoxybenzaldehyde Related Classifications
HY-Y1356 Related Classifications
Powered by Bioz