DTUN
DTUN is a lipophilic hyponitrite radical initiator. DTUN decomposes to form lipophilic alkoxyl radicals that initiate phospholipid peroxidation in liposomal egg phosphatidylcholine. DTUN can be used as a tool for research of ferroptosis.
For research use only. We do not sell to patients.
- CAS No.: 2934622-03-2
- Formula: C22H46N2O2
- Molecular Weight:370.61
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Storage:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
DTUN (200 μM) acts as a lipophilic initiator of phospholipid peroxidation in liposomal egg phosphatidylcholine suspensions, enabling measurement of radical-trapping antioxidant activity via STY-BODIPY oxidation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 2934622-03-2
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Appearance Liquid
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Molecular Weight 370.61
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Formula C22H46N2O2
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Color Colorless to light yellow
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SMILES
CC(C)(CCCCCCCC)O/N=N/OC(C)(CCCCCCCC)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
EtOH : 50 mg/mL (134.91 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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Ferroptosis Solutions
Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death characterized by lethal lipid peroxidation and sensitivity to suppression by iron chelators or lipophilic radical-trapping antioxidants. The core pathway links cystine uptake through system Xc−, glutathione availability, GPX4-dependent detoxification of phospholipid hydroperoxides, iron-dependent oxidative reactions, and polyunsaturated-phospholipid metabolism into a cell-death program that is biochemically and morphologically distinct from apoptosis, necrosis, and autophagy. The ferroptosis pathway is experimentally linked to phenotype through chemical and genetic perturbation. Erastin induces ferroptosis by inhibiting cystine uptake through system Xc− and weakening antioxidant defenses, while GPX4 inhibition or depletion causes lipid peroxide accumulation and ferroptotic cancer-cell death. ACSL4 and oxidizable arachidonoyl- or adrenoyl-containing phosphatidylethanolamines shape ferroptosis sensitivity by con
Purity & Documentation
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Data Sheet (265 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| EtOH | 1 mM | 2.6983 mL | 13.4913 mL | 26.9825 mL | 67.4564 mL |
| 5 mM | 0.5397 mL | 2.6983 mL | 5.3965 mL | 13.4913 mL | |
| 10 mM | 0.2698 mL | 1.3491 mL | 2.6983 mL | 6.7456 mL | |
| 15 mM | 0.1799 mL | 0.8994 mL | 1.7988 mL | 4.4971 mL | |
| 20 mM | 0.1349 mL | 0.6746 mL | 1.3491 mL | 3.3728 mL | |
| 25 mM | 0.1079 mL | 0.5397 mL | 1.0793 mL | 2.6983 mL | |
| 30 mM | 0.0899 mL | 0.4497 mL | 0.8994 mL | 2.2485 mL | |
| 40 mM | 0.0675 mL | 0.3373 mL | 0.6746 mL | 1.6864 mL | |
| 50 mM | 0.0540 mL | 0.2698 mL | 0.5397 mL | 1.3491 mL | |
| 60 mM | 0.0450 mL | 0.2249 mL | 0.4497 mL | 1.1243 mL | |
| 80 mM | 0.0337 mL | 0.1686 mL | 0.3373 mL | 0.8432 mL | |
| 100 mM | 0.0270 mL | 0.1349 mL | 0.2698 mL | 0.6746 mL |
DTUN Related Classifications
HY-164008 Related Classifications
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