Graphislactone A
Graphislactone A is an antioxidant, which is found in Cephalosporium IFB-E001 and M. olivacea. Graphislactone A inhibits acetylcholinesterase (AChE) with an IC50 value of 27 μM. Graphislactone A is promising for research of oxidative damage-initiated diseases.
For research use only. We do not sell to patients.
- CAS No.: 52179-44-9
- Formula: C16H14O6
- Molecular Weight:302.28
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | IC50 |
>10 μM
Compound: 10
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Cytotoxicity against human A2780 cells by MTT assay
Cytotoxicity against human A2780 cells by MTT assay
|
[PMID: 27441892] |
| BGC-823 | IC50 |
>10 μM
Compound: 10
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Cytotoxicity against human BGC823 cells by MTT assay
Cytotoxicity against human BGC823 cells by MTT assay
|
[PMID: 27441892] |
| HCT-116 | IC50 |
>10 μM
Compound: 10
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Cytotoxicity against human HCT116 cells by MTT assay
Cytotoxicity against human HCT116 cells by MTT assay
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[PMID: 27441892] |
| HepG2 | IC50 |
>10 μM
Compound: 10
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Cytotoxicity against human HepG2 cells by MTT assay
Cytotoxicity against human HepG2 cells by MTT assay
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[PMID: 27441892] |
| NCI-H1650 | IC50 |
>10 μM
Compound: 10
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Cytotoxicity against human NCI-H1650 cells by MTT assay
Cytotoxicity against human NCI-H1650 cells by MTT assay
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[PMID: 27441892] |
Chemical Information
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CAS No. 52179-44-9
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Molecular Weight 302.28
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Formula C16H14O6
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SMILES
O=C1OC2=C(C(OC)=CC(C)=C2C3=CC(OC)=CC(O)=C13)O
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Structure Classification
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Initial Source
Pilgerodendron uviferum
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Song YC, et al. Characterization of graphislactone A as the antioxidant and free radical-scavenging substance from the culture of Cephalosporium sp. IFB-E001, an endophytic fungus in Trachelospermum jasminoides. Biol Pharm Bull. 2005 Mar;28(3):506-9. [Content Brief]
[2]. Hormazabal E, et al. Metabolites from Microsphaeropsis olivacea, an endophytic fungus of Pilgerodendron uviferum. Z Naturforsch C J Biosci. 2005 Jan-Feb;60(1-2):11-21. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Graphislactone A Related Classifications
HY-122985 Related Classifications
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