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Mitazalimab  (Synonyms: ADC-1013; JNJ-64457107)

Cat. No.: HY-P99742 Purity: 98.06%
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Mitazalimab (ADC-1013; JNJ-64457107) is FcγR-dependent CD40 agonist with tumor-directed activity. Mitazalimab activates antigen-presenting cells, e.g. dendritic cells (DC), to initiate tumor-reactive T cells. Therefore, Mitazalimab induces tumor-specific T cells to infiltrate and kill tumors. Mitazalimab remodels the tumor-infiltrating myeloid microenvironment.

For research use only. We do not sell to patients.

Mitazalimab Chemical Structure

Mitazalimab Chemical Structure

CAS No. : 2055640-86-1

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Description

Mitazalimab (ADC-1013; JNJ-64457107) is FcγR-dependent CD40 agonist with tumor-directed activity. Mitazalimab activates antigen-presenting cells, e.g. dendritic cells (DC), to initiate tumor-reactive T cells. Therefore, Mitazalimab induces tumor-specific T cells to infiltrate and kill tumors. Mitazalimab remodels the tumor-infiltrating myeloid microenvironment[1][2].

IC50 & Target[1][2]

CD40

 

In Vitro

Mitazalimab (1 ng/mL-10 μg/mL) activates tumor associated macrophages (TAMs) in prostate tumor or ovarian tumor samples from human[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Mitazalimab (100 μg/mouse; i.p.; single dose) activates splenic DC and B cells in Naïve hCD40tg mice, and also results expansion of OVA-specifc CD8+ T cells in OVA-rechallenged (200 μg; i.v.; 3 times for 7 days between) mice[1].
Mitazalimab (100 and 300 μg/mouse, i.p.; on day 7, 10 and 13 post-inoculation) induces the release of proinfammatory cytokines and chemokines in the blood in MB49 (mouse bladder tumor cell line) bearing mice, and alters the composition of tumor myeloid cells, such that reduces monocytes and macrophages in favor of granulocytic cell[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MB49-tumor bearing mice model[1]
Dosage: 10, 30, 100 or 300 µg/mouse
Administration: Intraperitoneal injection; on day 7, 10 and 13 post-inoculation; sampled at 24 h after final dose
Result: Increased the level of IP-10, MIP-1α and TNF-α, but not CXCL1, IFN-γ, IL-6, IL-10, MCP-1 and MIP-2.
Resulted in increased frequency of CD44hi CD62L-efector memory CD8+ and CD4+ T cells.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Mitazalimab]

Shipping

Shipping with dry ice.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Purity: 98.06%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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