Zapalog
Based on 1 publication(s) in Google Scholar
Zapalog is a photocleavable small-molecule heterodimerizer that can be used to repeatedly initiate, and instantaneously terminate, a physical interaction between two target proteins. Zapalog dimerizes any two proteins tagged with the FKBP and DHFR domains until exposure to light causes its photolysis.
For research use only. We do not sell to patients.
- Purity: 99.62%
- CAS No.: 1708091-24-0
- Formula: C58H73N7O15
- Molecular Weight:1108.24
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Zapalog
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Biological Activity
FKBP, DHFR[1]
Chemical Information
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CAS No. 1708091-24-0
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Appearance Solid
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Molecular Weight 1108.24
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Formula C58H73N7O15
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Color White to yellow
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SMILES
O=C([C@H]1N(C(C(C(C)(C)CC)=O)=O)CCCC1)O[C@@H](C2=CC=CC(NC(CCCOC3=CC([N+]([O-])=O)=C(C(OCCOC4=C(OC)C=C(CC5=CN=C(N)N=C5N)C=C4OC)C)C=C3OC)=O)=C2)CCC6=CC=C(OC)C(OC)=C6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
DMSO : 100 mg/mL (90.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9023 mL | 4.5117 mL | 9.0233 mL | 22.5583 mL |
| 5 mM | 0.1805 mL | 0.9023 mL | 1.8047 mL | 4.5117 mL | |
| 10 mM | 0.0902 mL | 0.4512 mL | 0.9023 mL | 2.2558 mL | |
| 15 mM | 0.0602 mL | 0.3008 mL | 0.6016 mL | 1.5039 mL | |
| 20 mM | 0.0451 mL | 0.2256 mL | 0.4512 mL | 1.1279 mL | |
| 25 mM | 0.0361 mL | 0.1805 mL | 0.3609 mL | 0.9023 mL | |
| 30 mM | 0.0301 mL | 0.1504 mL | 0.3008 mL | 0.7519 mL | |
| 40 mM | 0.0226 mL | 0.1128 mL | 0.2256 mL | 0.5640 mL | |
| 50 mM | 0.0180 mL | 0.0902 mL | 0.1805 mL | 0.4512 mL | |
| 60 mM | 0.0150 mL | 0.0752 mL | 0.1504 mL | 0.3760 mL | |
| 80 mM | 0.0113 mL | 0.0564 mL | 0.1128 mL | 0.2820 mL |
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