1. Apoptosis
    Immunology/Inflammation
    Autophagy
  2. FKBP
  3. Zapalog

Zapalog 

Cat. No.: HY-126316
Handling Instructions

Zapalog is a photocleavable small-molecule heterodimerizer that can be used to repeatedly initiate, and instantaneously terminate, a physical interaction between two target proteins. Zapalog dimerizes any two proteins tagged with the FKBP and DHFR domains until exposure to light causes its photolysis.

For research use only. We do not sell to patients.

Zapalog Chemical Structure

Zapalog Chemical Structure

CAS No. : 1708091-24-0

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Description

Zapalog is a photocleavable small-molecule heterodimerizer that can be used to repeatedly initiate, and instantaneously terminate, a physical interaction between two target proteins. Zapalog dimerizes any two proteins tagged with the FKBP and DHFR domains until exposure to light causes its photolysis[1].

IC50 & Target

FKBP, DHFR[1]

Molecular Weight

1108.24

Formula

C₅₈H₇₃N₇O₁₅

CAS No.

1708091-24-0

SMILES

O=C([[email protected]]1N(C(C(C(C)(C)CC)=O)=O)CCCC1)O[[email protected]@H](C2=CC=CC(NC(CCCOC3=CC([N+]([O-])=O)=C(C(OCCOC4=C(OC)C=C(CC5=CN=C(N)N=C5N)C=C4OC)C)C=C3OC)=O)=C2)CCC6=CC=C(OC)C(OC)=C6

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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This equation is commonly abbreviated as: C1V1 = C2V2

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