2. MAPK/ERK Pathway PI3K/Akt/mTOR Epigenetics Anti-infection Immunology/Inflammation Metabolic Enzyme/Protease Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Apoptosis NF-κB
  3. p38 MAPK AMPK Bacterial Fungal Interleukin Related PPAR CDK PI3K Akt mTOR Apoptosis Reactive Oxygen Species (ROS)
  4. Sinigrin

Sinigrin  (Synonyms: Allyl-glucosinolate; 2-Propenyl-glucosinolate)

Cat. No.: HY-N0404 Purity: 99.92%
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Sinigrin (Allyl-glucosinolate) is an orally active glucosinolate found in cruciferous plants. Sinigrin possesses multiple activities such as anti-cancer, antibacterial, antifungal, anti-inflammatory, antioxidant, and inhibition of fat synthesis. Sinigrin can be used in the research of tumors, inflammatory, and metabolic diseases.

For research use only. We do not sell to patients.

CAS No. : 3952-98-5

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
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Based on 4 publication(s) in Google Scholar

Other Forms of Sinigrin:

Sinigrin Related Antibodies

Top Publications Citing Use of Products

    Sinigrin purchased from MedChemExpress. Usage Cited in: Phytother Res. 2025 May 8.  [Abstract]

    Cell proliferation of BPH-1 cells after treating by Sinigrin (10, 50, 100 μM) for 48h.

    Sinigrin purchased from MedChemExpress. Usage Cited in: Phytother Res. 2025 May 8.  [Abstract]

    Cloning efficiency of BPH-1 treated with LPS and Sinigrin (50, 100 μM) for 7days.

    Sinigrin purchased from MedChemExpress. Usage Cited in: Phytother Res. 2025 May 8.  [Abstract]

    Western Blot analysis of PI3K/AKT/mTOR pathway in RWPE-1 and BPH-1 cells after treating with 50μM Sinigrin for 48h.

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    p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

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    NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1 BRSK1 BRSK2 HUNK AMPKα

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    IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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    PPARα PPARβ/δ PPARγ PPAR PPARδ

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    • Biological Activity

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    Description

    Sinigrin (Allyl-glucosinolate) is an orally active glucosinolate found in cruciferous plants. Sinigrin possesses multiple activities such as anti-cancer, antibacterial, antifungal, anti-inflammatory, antioxidant, and inhibition of fat synthesis. Sinigrin can be used in the research of tumors, inflammatory, and metabolic diseases[1][2][3][4].

    IC50 & Target[1][2]

    PPARγ

     

    IL-6

     

    IL-1β

     

    CDK4

     

    CDK6

     

    In Vitro

    Sinigrin (1-100 μg/mL; 1-8 days) inhibits lipid accumulation, downregulates the expression of adipogenesis-related genes, suppresses the production of pro-inflammatory cytokines (TNF-α, IL-6, IL-1β, IL-18), and induces cell cycle arrest in 3T3-L1 cells. The mechanism involves activation of the AMPK pathway and inhibition of the MAPK pathway[1].
    Sinigrin (5-30 μM; 24-48 h) induces cell cycle arrest in the S phase and promotes apoptosis, while triggering ROS-dependent oxidative stress damage by inhibiting PI3K/AKT/mTOR phosphorylation in MCF-7 cells[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Sinigrin Related Antibodies

    Cell Cycle Analysis[1]

    Cell Line: 3T3-L1 adipocytes
    Concentration: 100 μg/mL
    Incubation Time: 24 h
    Result: Arrested cells in the G0/G1phase of the cell cycle and increased the expression of p21 and p27.

    Western Blot Analysis[1]

    Cell Line: 3T3-L1 adipocytes
    Concentration: 1, 10, and 100 μg/mL
    Incubation Time: 8 days
    Result: Remarkably inhibited the accumulation of lipid droplets and adipogenesis by downregulating the expression of CCAAT-enhancer-binding protein α (C/EBPα), PPARγ, leptin and aP2.

    RT-PCR[1]

    Cell Line: 3T3-L1 adipocytes
    Concentration: 1, 10, and 100 μg/mL
    Incubation Time: 8 days
    Result: Inhibited the production of pro-inflammatory cytokines including TNF-α and IL-6, IL-1β and IL-18.

    Western Blot Analysis[2]

    Cell Line: MCF-7 cells
    Concentration: 20 μM
    Incubation Time: 24 and 48 h
    Result: Inhibited the levels of cyclin-D1, PCNA, CDK4, and CDK6.
    In Vivo

    Sinigrin (15-30 mg/kg; oral administration; 12 days) exerts anti-inflammatory and ameliorative effects in DSS (HY-116282C)-induced ulcerative colitis mouse models[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male BALB/c mice (20-25 gm) treated DSS (HY-116282C)[3]
    Dosage: 15 and 30 mg/kg
    Administration: Oral administration; 12 days
    Result: Significantly mitigated the DSS-induced body weight loss, attenuated the colon length shrinkage, and improved the disease index score.
    Successfully abrogated the DSS-induced IL-17 levels and improved the colonic barrier in colon tissues.
    Molecular Weight

    397.46

    Formula

    C10H16KNO9S2
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O[C@@H]1[C@@H](O)[C@H](S/C(CC=C)=N/OS(=O)(O[K])=O)O[C@H](CO)[C@H]1O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    Solvent & Solubility
    In Vitro: 

    H2O : 25 mg/mL (62.90 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.5160 mL 12.5799 mL 25.1598 mL
    5 mM 0.5032 mL 2.5160 mL 5.0320 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.97%

    SDS (393 KB)

    COA (254 KB) HNMR (273 KB) RP-HPLC (247 KB) MS (175 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 2.5160 mL 12.5799 mL 25.1598 mL 62.8994 mL
    5 mM 0.5032 mL 2.5160 mL 5.0320 mL 12.5799 mL
    10 mM 0.2516 mL 1.2580 mL 2.5160 mL 6.2899 mL
    15 mM 0.1677 mL 0.8387 mL 1.6773 mL 4.1933 mL
    20 mM 0.1258 mL 0.6290 mL 1.2580 mL 3.1450 mL
    25 mM 0.1006 mL 0.5032 mL 1.0064 mL 2.5160 mL
    30 mM 0.0839 mL 0.4193 mL 0.8387 mL 2.0966 mL
    40 mM 0.0629 mL 0.3145 mL 0.6290 mL 1.5725 mL
    50 mM 0.0503 mL 0.2516 mL 0.5032 mL 1.2580 mL
    60 mM 0.0419 mL 0.2097 mL 0.4193 mL 1.0483 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Sinigrin Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Sinigrin3952-98-5Allyl-glucosinolate 2-Propenyl-glucosinolatep38 MAPKAMPKBacterialFungalInterleukin RelatedPPARCDKPI3KAktmTORApoptosisReactive Oxygen Species (ROS)AMP-activated protein kinaseILPeroxisome proliferator-activated receptorsCyclin dependent kinasePhosphoinositide 3-kinasePKBProtein kinase BMammalian target of Rapamycinadipogenesisadipocytedifferentiationulcerative colitis model3T3-L1 cellsMCF-7 cellsInhibitorinhibitorinhibit

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