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Asp-Lys

" in MedChemExpress (MCE) Product Catalog:

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By Research Areas:	Cancer (78) Cardiovascular Disease (14) Endocrinology (5) Infection (15) Inflammation/Immunology (38) Metabolic Disease (26) Neurological Disease (21)
Click Chemistry:	Azide (1) Alkynes (1)
Oligonucleotides:	Cationic Lipids (1)

287

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

181

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Oligonucleotides

ASP-8731	Heme Oxygenase (HO) NF-κB Transmembrane Glycoprotein	Cardiovascular Disease
ASP-8731 is an orally active BACH1 inhibitor. ASP-8731 activates antioxidant, anti-inflammatory and globin gene pathways by relieving the inhibitory effect of BACH1 on NRF2-mediated gene transcription. ASP-8731 significantly upregulates the expression of HMOX1, FTH1 and various globins (such as HGB, HBG, HBA), increases fetal hemoglobin (HbF) levels, and effectively induces F-cell production in hydroxyurea-unresponsive cells. Meanwhile, ASP-8731 reduces inflammatory responses and white blood cell counts by downregulating VCAM1, ICAM-1 and the phosphorylation level of NF-κB(p65), and blocks heme-induced glutathione depletion and microcirculatory stasis. ASP-8731 holds potential for inhibiting sickle cell disease and related hematological disorders .

4-Di-1-ASP	Fluorescent Dye	Cancer
4-Di-1-ASP is a styryl dye used to stain glioma cells in living brain tissue for analysis of cell structure, viability, proliferation and endocytosis, cytokinesis and phagocytosis, as well as for observation of mitochondrial structures in living cells. 4-Di-1-ASP fluoresces green when imaged microscopically (λ_ex /λ_em = 475/606 nm) .

ASP-9521 3 Publications Verification	17β-HSD	Cancer
ASP-9521 is a potent, selective and orally available AKR1C3 inhibitor with an IC₅₀ of 11 nM for human AKR1C3.

ASP3026 5+ Cited Publications	Anaplastic lymphoma kinase (ALK) Apoptosis ROS Kinase Caspase PARP IGF-1R STAT Akt JNK	Cancer
ASP3026 is a selective and orally active inhibitor of anaplastic lymphoma kinase (ALK). ASP3026 is a selective and oral active anaplastic lymphoma kinase (ALK) inhibitor with a IC₅₀ value of 3.5 nM. ASP3026 can inhibit the phosphorylation of IGF-1R, STAT3, AKT and JNK proteins, and induce the cleavage of caspase 3 and PARP. It also inhibited ROS and ACK. ASP3026 can be used in anti-tumor research .

2-Di-1-ASP DAspI	G-quadruplex	Others
2-Di-1-ASP (DASPI; Compound 18a) is a mono-stryryl dye, and widely used as mitochondrial stain and groove-binding fluorescent probes for double-stranded DNA. 2-Di-1-ASP is selective for G-quadruplex (G4) and double-stranded DNA .

*Z-Ala-Ala-Asp-CMK* 2 Publications Verification Z-AAD-CMK	Caspase Apoptosis Reactive Oxygen Species (ROS) Interleukin Related	Inflammation/Immunology Cancer
Z-Ala-Ala-Asp-CMK (Z-AAD-CMK) is a selective granzyme B inhibitor. By binding to the active site of granzyme B, Z-Ala-Ala-Asp-CMK blocks its proteolytic function. Z-Ala-Ala-Asp-CMK has anti-inflammatory activity and can be used in the research of inflammatory diseases and cancer .

4-Di-2-ASP	Fluorescent Dye	Others
4-Di-2-ASP, a styryl pyridinium fluorescent dye, is a vital mitochondrial marker. 4-Di-2-ASP shows reliable and specific labelling of pulmonary NEBs (neuroepithelial bodies) .

ASP7663 2 Publications Verification	TRP Channel	Neurological Disease
ASP7663 is an orally active and selective TRPA1 agonist. ASP7663 exerts both anti-constipation and anti-abdominal pain actions .

*Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA* Cyclo(RGDfV) TFA; C(RGDfV) TFA	Integrin Apoptosis	Cancer
Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) (Cyclo(RGDfV) (TFA))is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) can be used for the research of acute myeloid leukemia .

*Fmoc-Asp-OtBu*	Amino Acid Derivatives	Others
Fmoc-Asp-OtBu is an aspartic acid derivative .

*Fmoc-Asp(OAll)-OH*	Amino Acid Derivatives	Others
Fmoc-Asp(OAll)-OH is an aspartic acid derivative .

*Gly-Asp-Asp-Asp-Asp-Lys-β-naphthylamide* GD4K-na	Enteropeptidase	Others
Gly-Asp-Asp-Asp-Asp-Lys-β-naphthylamide (GD4K-na) is a substrate for human enteropeptidase (K_m: 0.16 mM) .

**Asp-Asp-Asp-Asp-Asp-Asp**	Influenza Virus	Infection
Asp-Asp-Asp-Asp-Asp-Asp is a polyaspartic acid. The specificity of the catalytic and antigenic sites of influenza virus neuraminidase is related to the number of specific amino acids.

ASP8302	mAChR	Endocrinology
ASP8302 is a positive and allosteric muscarinic M3 receptor modulator. ASP8302 improves voiding efficiency and reduced residual urine volume in two voiding dysfunction models. ASP8302 can be used for research of underactive bladder .

ASP4132 1 Publications Verification	AMPK	Cancer
ASP4132 is an orally active, potent AMPK activator with an EC₅₀ of 18 nM. ASP4132 has anti-cancer activity and makes tumor regression in breast cancer xenograft mouse models .

*Boc-Asp(OtBu)-OH*	Amino Acid Derivatives	Others
Boc-Asp(OtBu)-OH is an aspartic acid derivative .

4-Di-10-ASP	Fluorescent Dye	Others
4-Di-10-ASP is a fluorescent lipophilic tracer (Excitation 485 nm; Emission 620 nm). 4-Di-10-ASP can be used to stain phospholipid membranes in a specific manner .

*Cyclo(Arg-Gly-Asp-(D-Phe)-Glu)* c(RGDfE)	Integrin	Cancer
Cyclo(Arg-Gly-Asp-(D-Phe)-Glu) c(RGDfE) is a cyclic RGD peptide targeting integrin αvβ3. Cyclo(Arg-Gly-Asp-(D-Phe)-Glu) is commonly used for modifying drug loaded nanoparticles. Cyclo(Arg-Gly-Asp-(D-Phe)-Glu) is often used in cancer research, such as pancreatic cancer .

*Fmoc-Asp-OMe*	Amino Acid Derivatives	Others
Fmoc-Asp-OMe is an aspartic acid derivative .

*Fmoc-Asp(OtBu)-Osu*	Amino Acid Derivatives	Others
Fmoc-Asp(OtBu)-Osu is an aspartic acid derivative .

*AC-Asp(OtBU)-OH*	Amino Acid Derivatives	Others
AC-Asp(OtBU)-OH is an aspartic acid derivative .

*Z-Asp(OBzl)-OH*	Amino Acid Derivatives	Others
Z-Asp(OBzl)-OH is an aspartic acid derivative .

*Boc-Asp(OMe)-OH*	Amino Acid Derivatives	Others
Boc-Asp(OMe)-OH is an aspartic acid derivative .

*Fmoc-Asp(CSY)-OH*	Amino Acid Derivatives	Others
Fmoc-Asp(CSY)-OH is an aspartic acid derivative .

4-Di-16-ASP DiA	Fluorescent Dye	Others
4-Di-16-ASP is a green fluorescent membrane dye. 4-Di-16-ASP is a lipophilic aminostyryl probe with a broad emission spectrum (can be detected with green, orange or even red filters). It is commonly used for neuronal membrane tracing (it diffuses faster than DiO) .

*Boc-Ala-Ala-Asp-pNA*	Caspase	Cancer
Boc-Ala-Ala-Asp-pNA is a chromogenic substrate of granzyme B. Boc-Ala-Ala-Asp-pNA can be used to test functional activity of granzyme B .

*Boc-Asp-OMe*	Amino Acid Derivatives	Others
Boc-Asp-OMe is an aspartic acid derivative .

ASP2453 1 Publications Verification	Ras ERK	Cancer
ASP2453 is a potent, selective and orally active KRAS G12C inhibitor. ASP2453 inhibits the Son of Sevenless (SOS)-mediated interaction between KRAS G12C and Raf with an IC₅₀ value of 40 nM.

*H-Asp(OtBu)-OMe.HCl*	Amino Acid Derivatives	Others
H-Asp(OtBu)-OMe.HCl is an aspartic acid derivative .

*H-Asp-Gly-OH*	ADC Linker	Cancer
H-Asp-Gly-OH is a cleavable ADC linker.

*Z-Asp(OtBu)-OH*	Amino Acid Derivatives	Others
Z-Asp(OtBu)-OH is an aspartic acid derivative .

*[Asp5]-Oxytocin acetate*	Oxytocin Receptor	Endocrinology
[Asp5]-Oxytocin acetate is the first 5-position neurohypophyseal hormone analogue possessing significant biological activity. [Asp5]-Oxytocin acetate causes uterine contractions in vitro, enhanced by Mg ²⁺. [Asp5]-Oxytocin acetate has the ability of rat uteroconstrictor, avian vasodilator, and rat antidiuretic .

*Fmoc-Asp(OMpe)-Asp(OMpe)-OH*	Amino Acid Derivatives	Others
Fmoc-Asp(OMpe)-Asp(OMpe)-OH is a dimer of aspartic acid.

*(Asp28)-Glucagon (1-29) (human, rat, porcine)*	GLP Receptor	Metabolic Disease
(Asp28)-Glucagon (1-29) (human, rat, porcine) is an optimized structure of glucagon, the 28th position is replaced by aspartic acid (Asp) which significantly increases the aqueous solubility of glucagon in a physiological pH buffer, has the same activity as glucagon .

*Fmoc-Asp-Obzl*	Amino Acid Derivatives	Others
Fmoc-Asp-Obzl is an aspartic acid derivative .

*Z-Asp-OBzl*	Amino Acid Derivatives	Others
Z-Asp-OBzl is an aspartic acid derivative .

*Z-Asp-OH*	Amino Acid Derivatives	Others
Z-Asp-OH is an aspartic acid derivative .

*Z-Asp-OMe*	Amino Acid Derivatives	Others
Z-Asp-OMe is an aspartic acid derivative .

*Z-Asp(OMe)-OH*	Amino Acid Derivatives	Others
Z-Asp(OMe)-OH is an aspartic acid derivative .

*Fmoc-D-Asp-OH*	Amino Acid Derivatives	Others
Fmoc-D-Asp-OH is an aspartic acid derivative .

ASP6537 FK881	COX	Cardiovascular Disease
ASP6537 is a potent and selective rhCOX-1 inhibitor with an IC₅₀ of 0.703 nM. ASP6537 has the potential for cardiovascular disease research .

*H-Asp(AMC)-OH*	Fluorescent Dye	Others
H-Asp(AMC)-OH, a amino acid derivative, is a fluorescent dye. H-Asp(AMC)-OH dose not inhibit glycine transport at a concentration of 0.25 mM .

*Cyclo(Arg-Gly-Asp-D-Phe-Val)* Cyclo(RGDfV); C(RGDfV)	Integrin Apoptosis	Cancer
Cyclo(Arg-Gly-Asp-D-Phe-Val) (Cyclo(RGDfV)) is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) can be used for the research of acute myeloid leukemia .

*Boc-Asp-OH*	Amino Acid Derivatives	Others
Boc-Asp-OH is an aspartic acid derivative .

*H-Asp-OMe*	Amino Acid Derivatives	Others
H-Asp-OMe is an aspartic acid derivative .

*H-Asp(Obzl)-OtBu.HCl*	Amino Acid Derivatives	Others
H-Asp(Obzl)-OtBu.HCl is an aspartic acid derivative .

Cat. No.	Product Name	Type

HY-W094758A

4-Di-1-ASP	Fluorescent Dyes
4-Di-1-ASP is a styryl dye used to stain glioma cells in living brain tissue for analysis of cell structure, viability, proliferation and endocytosis, cytokinesis and phagocytosis, as well as for observation of mitochondrial structures in living cells. 4-Di-1-ASP fluoresces green when imaged microscopically (λ_ex /λ_em = 475/606 nm) .

HY-135009

2-Di-1-ASP DAspI	Fluorescent Dyes
2-Di-1-ASP (DASPI; Compound 18a) is a mono-stryryl dye, and widely used as mitochondrial stain and groove-binding fluorescent probes for double-stranded DNA. 2-Di-1-ASP is selective for G-quadruplex (G4) and double-stranded DNA .

HY-D0060

4-Di-2-ASP	Fluorescent Dyes
4-Di-2-ASP, a styryl pyridinium fluorescent dye, is a vital mitochondrial marker. 4-Di-2-ASP shows reliable and specific labelling of pulmonary NEBs (neuroepithelial bodies) .

HY-P3236

*N-Acetyl-Ile-Glu-Pro-Asp-p-nitroanilide* Ac-IEPD-pNA	Fluorescent Dyes
N-Acetyl-Ile-Glu-Pro-Asp-p-nitroanilide (Ac-IEPD-pNA) is a colorimetric peptide substrate of granzyme B that allows accurate measurement of granzyme B activity .

HY-D1630

4-Di-10-ASP	Fluorescent Dyes
4-Di-10-ASP is a fluorescent lipophilic tracer (Excitation 485 nm; Emission 620 nm). 4-Di-10-ASP can be used to stain phospholipid membranes in a specific manner .

HY-133876

4-Di-16-ASP DiA	Fluorescent Dyes
4-Di-16-ASP is a green fluorescent membrane dye. 4-Di-16-ASP is a lipophilic aminostyryl probe with a broad emission spectrum (can be detected with green, orange or even red filters). It is commonly used for neuronal membrane tracing (it diffuses faster than DiO) .

HY-W142117

*H-Asp(AMC)-OH*	Fluorescent Dyes
H-Asp(AMC)-OH, a amino acid derivative, is a fluorescent dye. H-Asp(AMC)-OH dose not inhibit glycine transport at a concentration of 0.25 mM .

HY-W338079

*Ac-Asp-Glu-Val-Asp-pNA*	Fluorescent Dyes
Ac-Asp-Glu-Val-Asp-pNA is a peptidic substrate of caspase-3/7 .

Cat. No.	Product Name	Type

HY-W015824

DL-Aspartic acid DL-Asp-OH	Biochemical Assay Reagents
DL-Aspartic acid (DL-Asp-OH) is a kind of biological materials or organic compounds that are widely used in life science research .

HY-163991

*(Z-Asp-Glu-Val-Asp)2-Rh110*	Biochemical Assay Reagents
(Z-Asp-Glu-Val-Asp)2-Rh110 is a biochemical reagent.

HY-182092C

*DSPE-PEG3400-Asp6*	Biochemical Assay Reagents
DSPE-PEG3400-Asp6 is a PEG compound which composed of DSPE and a Asp6 peptide. DSPE-PEG3400-Asp6 achieves bone-targeted delivery of drugs or imaging agents by binding to bone tissue with the Asp6 peptide through high affinity .

HY-182092

*DSPE-PEG1000-Asp6*	Biochemical Assay Reagents
DSPE-PEG1000-Asp6 is a PEG compound which composed of DSPE and a Asp6 peptide. DSPE-PEG1000-Asp6 achieves bone-targeted delivery of drugs or imaging agents by binding to bone tissue with the Asp6 peptide through high affinity .

HY-182092A

*DSPE-PEG5000-Asp6*	Biochemical Assay Reagents
DSPE-PEG5000-Asp6 is a PEG compound which composed of DSPE and a Asp6 peptide. DSPE-PEG5000-Asp6 achieves bone-targeted delivery of drugs or imaging agents by binding to bone tissue with the Asp6 peptide through high affinity .

HY-182092B

*DSPE-PEG2000-Asp6*	Biochemical Assay Reagents
DSPE-PEG2000-Asp6 is a PEG compound which composed of DSPE and a Asp6 peptide. DSPE-PEG2000-Asp6 achieves bone-targeted delivery of drugs or imaging agents by binding to bone tissue with the Asp6 peptide through high affinity .

HY-W015824R

DL-Aspartic acid (Standard) DL-Asp-OH (Standard)	Biochemical Assay Reagents
DL-Aspartic acid (Standard) is the analytical standard of DL-Aspartic acid. This product is intended for research and analytical applications. DL-Aspartic acid (DL-Asp-OH) is a kind of biological materials or organic compounds that are widely used in life science research .

Cat. No.	Product Name	Target	Research Area

HY-P0319

3X FLAG peptide Maximum Cited Publications 24 Publications Verification	Biochemical Assay Reagents	Others
3X FLAG peptides are FLAG-tagged peptides containing three repeats of the Asp-Tyr-Lys-Xaa-Xaa-Asp motif. 3X FLAG peptide can be used for protein separation and purification, and competitive elution with target proteins.

HY-P0319A

3X FLAG peptide TFA Maximum Cited Publications 24 Publications Verification	Peptides	Others
3X FLAG peptide TFA is a FLAG-tagged peptide containing three repeats of the Asp-Tyr-Lys-Xaa-Xaa-Asp motif. 3X FLAG peptide TFA can be used for protein separation and purification, and competitive elution with target proteins.

HY-Y1169

*Fmoc-Asp(OtBu)-OH* 4-tert-Butyl N-(fluoren-9-ylmethoxycarbonyl)-L-Aspartate; Fmoc-L-Asp(OtBu)-OH	Amino Acid Derivatives	Others
Fmoc-Asp(OtBu)-OH (4-tert-Butyl N-(fluoren-9-ylmethoxycarbonyl)-L-aspartate) is an aspartate derivative containing amine protecting group Fmoc. Fmoc-Asp(OtBu)-OH can be used for peptide synthesis .

HY-12290

*Arg-Gly-Asp-Ser* 5+ Cited Publications RGDS peptide; Fibronectin tetrapeptide	Integrin	Inflammation/Immunology
Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1.

HY-P2300

*Cyclo(Arg-Gly-Asp-D-Phe-Cys)* 2 Publications Verification Cyclo(RGDfC)	Integrin	Cancer
Cyclo(Arg-Gly-Asp-D-Phe-Cys) (Cyclo RGDfC), a cyclic RGD peptide which has high affinity to αvβ3, can disrupt cell integrin interactions. Cyclo(Arg-Gly-Asp-D-Phe-Cys) inhibits pluripotent marker expression in embryonic stem cells (ESCs) and the tumorigenic potential of mESCs in vivo. Cyclo(Arg-Gly-Asp-D-Phe-Cys) can be used in the research of tumors .

HY-P10004

*Z-Ala-Ala-Asp-CMK* 2 Publications Verification Z-AAD-CMK	Caspase Apoptosis Reactive Oxygen Species (ROS) Interleukin Related	Inflammation/Immunology Cancer
Z-Ala-Ala-Asp-CMK (Z-AAD-CMK) is a selective granzyme B inhibitor. By binding to the active site of granzyme B, Z-Ala-Ala-Asp-CMK blocks its proteolytic function. Z-Ala-Ala-Asp-CMK has anti-inflammatory activity and can be used in the research of inflammatory diseases and cancer .

HY-P10925A

(Z)-Zolucatetide (Z)-FOG-001; I-67	β-catenin	Cancer
(Z)-Zolucatetide (I-67) is a β-catenin inhibitor with IC₅₀ ≤50 nM. (Z)-Zolucatetide's sequence is Ac-PL3-Asp-Npg-B5-Asp-3COOHF-Aib-Ala-Phe-Lys3-PyrS2-3Thi-BztA-GlnR3-Ala-NH₂. (Z)-Zolucatetide can be used for cancer research .

HY-P1613A

*Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA* Cyclo(RGDfV) TFA; C(RGDfV) TFA	Integrin Apoptosis	Cancer
Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) (Cyclo(RGDfV) (TFA))is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) can be used for the research of acute myeloid leukemia .

HY-W010959

*Fmoc-Asp-OtBu*	Amino Acid Derivatives	Others
Fmoc-Asp-OtBu is an aspartic acid derivative .

HY-W008075

*Fmoc-Asp(OAll)-OH*	Amino Acid Derivatives	Others
Fmoc-Asp(OAll)-OH is an aspartic acid derivative .

HY-P2660

*Gly-Asp-Asp-Asp-Asp-Lys-β-naphthylamide* GD4K-na	Enteropeptidase	Others
Gly-Asp-Asp-Asp-Asp-Lys-β-naphthylamide (GD4K-na) is a substrate for human enteropeptidase (K_m: 0.16 mM) .

HY-P3823

**Asp-Asp-Asp-Asp-Asp-Asp**	Influenza Virus	Infection
Asp-Asp-Asp-Asp-Asp-Asp is a polyaspartic acid. The specificity of the catalytic and antigenic sites of influenza virus neuraminidase is related to the number of specific amino acids.

HY-W002326

*Boc-Asp(OtBu)-OH*	Amino Acid Derivatives	Others
Boc-Asp(OtBu)-OH is an aspartic acid derivative .

HY-P0295

*Gly-Arg-Gly-Asp-Ser* GRGDS	Integrin	Others
Gly-Arg-Gly-Asp-Ser (GRGDS) is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin. Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3 and αvβ5 with estimated IC₅₀ of ～5 and ～6.5 μM

HY-P5021

*Cyclo(Arg-Gly-Asp-(D-Phe)-Glu)* c(RGDfE)	Integrin	Cancer
Cyclo(Arg-Gly-Asp-(D-Phe)-Glu) c(RGDfE) is a cyclic RGD peptide targeting integrin αvβ3. Cyclo(Arg-Gly-Asp-(D-Phe)-Glu) is commonly used for modifying drug loaded nanoparticles. Cyclo(Arg-Gly-Asp-(D-Phe)-Glu) is often used in cancer research, such as pancreatic cancer .

HY-W041982

*Fmoc-Asp-OMe*	Amino Acid Derivatives	Others
Fmoc-Asp-OMe is an aspartic acid derivative .

HY-137950

*Fmoc-Asp(OtBu)-Osu*	Amino Acid Derivatives	Others
Fmoc-Asp(OtBu)-Osu is an aspartic acid derivative .

HY-W024554

*AC-Asp(OtBU)-OH*	Amino Acid Derivatives	Others
AC-Asp(OtBU)-OH is an aspartic acid derivative .

HY-30231

*Z-Asp(OBzl)-OH*	Amino Acid Derivatives	Others
Z-Asp(OBzl)-OH is an aspartic acid derivative .

HY-W007399

*Boc-Asp(OMe)-OH*	Amino Acid Derivatives	Others
Boc-Asp(OMe)-OH is an aspartic acid derivative .

HY-W142115

*Fmoc-Asp(CSY)-OH*	Amino Acid Derivatives	Others
Fmoc-Asp(CSY)-OH is an aspartic acid derivative .

HY-W013144

*Fmoc-D-Asp(OtBu)-OH*	Amino Acid Derivatives	Others
Fmoc-D-Asp(OtBu)-OH is an aspartic acid derivative .

HY-W013740

*Fmoc-N-Me-Asp(OtBu)-OH*	Amino Acid Derivatives	Others
Fmoc-N-Me-Asp(OtBu)-OH is an aspartic acid derivative .

HY-P2300A

*Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA* 2 Publications Verification Cyclo(RGDfC) TFA	Integrin	Cancer
Cyclo(Arg-Gly-Asp-D-Phe-Cys) (Cyclo RGDfC) TFA, a cyclic RGD peptide which has high affinity to αvβ3, can disrupt cell integrin interactions. Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA inhibits pluripotent marker expression in embryonic stem cells (ESCs) and the tumorigenic potential of mESCs in vivo. Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA can be used in the research of tumors .

HY-P4453

*Boc-Ala-Ala-Asp-pNA*	Caspase	Cancer
Boc-Ala-Ala-Asp-pNA is a chromogenic substrate of granzyme B. Boc-Ala-Ala-Asp-pNA can be used to test functional activity of granzyme B .

HY-W018741

*Boc-Asp-OMe*	Amino Acid Derivatives	Others
Boc-Asp-OMe is an aspartic acid derivative .

HY-W018489

*H-Asp(OtBu)-OMe.HCl*	Amino Acid Derivatives	Others
H-Asp(OtBu)-OMe.HCl is an aspartic acid derivative .

HY-W011278

*Z-Asp(OtBu)-OH*	Amino Acid Derivatives	Others
Z-Asp(OtBu)-OH is an aspartic acid derivative .

HY-W007108

*Fmoc-Asp(ODMAB)-OH*	Amino Acid Derivatives	Others
Fmoc-Asp(ODMAB)-OH is an aspartic acid derivative .

HY-P2016

*Ac-Nle-Pro-Nle-Asp-AMC*	Proteasome	Others
Ac-Nle-Pro-Nle-Asp-AMC is a specific substrate for 26S proteasome. Ac-Nle-Pro-Nle-Asp-AMC can be used for the 26S proteasome caspase-like activity analysis .

HY-P3726

*Lys-Gln-Ala-Gly-Asp-Val*	Integrin	Inflammation/Immunology Cancer
Lys-Gln-Ala-Gly-Asp-Val (KQAGDV) is the six most carboxyl-terminal amino acids in the fibrinogen γ-chain sequence. Lys-Gln-Ala-Gly-Asp-Val is a cell adhesion peptide which is mediated through the α_2bβ₃ integrin. Lys-Gln-Ala-Gly-Asp-Val is a potent adhesion ligand for smooth muscle cells (SMCs) .

HY-W016749

N-Acetyl-DL-aspartic acid Ac-DL-Asp-OH	Amino Acid Derivatives	Others
N-Acetyl-DL-aspartic acid (Ac-DL-Asp-OH) is an aspartic acid derivative .

HY-P4305

*Asp-Lys*	Peptides	Others
Asp-Lys is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P3217A

*[Asp5]-Oxytocin acetate*	Oxytocin Receptor	Endocrinology
[Asp5]-Oxytocin acetate is the first 5-position neurohypophyseal hormone analogue possessing significant biological activity. [Asp5]-Oxytocin acetate causes uterine contractions in vitro, enhanced by Mg ²⁺. [Asp5]-Oxytocin acetate has the ability of rat uteroconstrictor, avian vasodilator, and rat antidiuretic .

HY-P4389

*(Asp28)-Glucagon (1-29) (human, rat, porcine)*	GLP Receptor	Metabolic Disease
(Asp28)-Glucagon (1-29) (human, rat, porcine) is an optimized structure of glucagon, the 28th position is replaced by aspartic acid (Asp) which significantly increases the aqueous solubility of glucagon in a physiological pH buffer, has the same activity as glucagon .

HY-W008360

*Fmoc-Asp-Obzl*	Amino Acid Derivatives	Others
Fmoc-Asp-Obzl is an aspartic acid derivative .

HY-W008685

*Z-Asp-OBzl*	Amino Acid Derivatives	Others
Z-Asp-OBzl is an aspartic acid derivative .

HY-W011703

*Z-Asp-OH*	Amino Acid Derivatives	Others
Z-Asp-OH is an aspartic acid derivative .

HY-W009328

*Z-Asp-OMe*	Amino Acid Derivatives	Others
Z-Asp-OMe is an aspartic acid derivative .

HY-W011553

*Z-Asp(OMe)-OH*	Amino Acid Derivatives	Others
Z-Asp(OMe)-OH is an aspartic acid derivative .

HY-W011126

*Fmoc-D-Asp-OH*	Amino Acid Derivatives	Others
Fmoc-D-Asp-OH is an aspartic acid derivative .

HY-W004083

*Boc-D-Asp(OBzl)-OH*	Amino Acid Derivatives	Others
Boc-D-Asp(OBzl)-OH is an aspartic acid derivative .

HY-W015233

*H-D-Asp(OtBu)-OH*	Amino Acid Derivatives	Others
H-D-Asp(OtBu)-OH is an aspartic acid derivative .

HY-W041999

*H-D-Asp(OMe)-OMe.HCl*	Amino Acid Derivatives	Others
H-D-Asp(OMe)-OMe.HCl is an aspartic acid derivative .

HY-P10461

*Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp*	Peptides	Others
Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp is a fluorescence-quenched peptide substrate for human proteinase 3 (k_cat/K_m = 1,570 mM ^-1s ^-1), and can be used for detection of proteinase 3 (PR3) activity .

HY-120833

*Ac-Ile-Glu-Thr-Asp-pNA*	Caspase	Others
Ac-Ile-Glu-Thr-Asp-pNA is a substrate for caspase-8. Caspase-8 binds to and cleaves the Ile-Glu-Thr-Asp (IETD) peptide sequence to release p-nitroalinide, which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity .

HY-P0321

**Asp-Asp-Asp-Asp-Asp**	Peptides	Metabolic Disease
Asp-Asp-Asp-Asp-Asp is a peptide consists of 5 Asp.

HY-P4313

Asp-Val	Peptides	Others
Asp-Val is a dipeptide formed from L-alpha-aspartyl and L-valine residues. Asp-Val has a role as a metabolite. Asp-Val can be isolated from an enzymatic hydrolysate of food proteins .

HY-W142117

*H-Asp(AMC)-OH*	Fluorescent Dye	Others
H-Asp(AMC)-OH, a amino acid derivative, is a fluorescent dye. H-Asp(AMC)-OH dose not inhibit glycine transport at a concentration of 0.25 mM .

HY-P1613

*Cyclo(Arg-Gly-Asp-D-Phe-Val)* Cyclo(RGDfV); C(RGDfV)	Integrin Apoptosis	Cancer
Cyclo(Arg-Gly-Asp-D-Phe-Val) (Cyclo(RGDfV)) is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) can be used for the research of acute myeloid leukemia .

Cat. No.	Product Name

HY-KE7022

Kpn I
MCE Kpn I is a restriction enzyme for rapid DNA digestion, including plasmid, genomic DNA as well as PCR products. Isoschizomers: Asp718 I, Acc65 I.

Cat. No.	Product Name	Target	Research Area	Image

HY-P990774

Verekitug Asp-7266; TRAB-1; UPB-101	Interleukin Related	Inflammation/Immunology
Verekitug (ASP-7266; TRAB-1; UPB-101) is a human monoclonal antibody targeting the thymic stromal lymphopoietin receptor (TSLPR), with a mean half-life of approximately 20 days. At doses of Verekitug ≥100 mg, complete and sustained TSLPR-specific occupancy is achieved, and the antibody does not bind to IL-7Rα. By inhibiting TSLP-driven inflammatory responses, Verekitug blocks TSLP-induced cell proliferation and TARC expression, while reducing fractional exhaled NO levels, blood eosinophil counts, and levels of IL-5 and IgE. Verekitug significantly improves scores for nasal polyps, nasal congestion and olfactory dysfunction, with favorable safety and good tolerability; potential adverse reactions include headache, upper respiratory tract infection, sinusitis and nasopharyngitis. Verekitug is used in relevant studies on asthma, chronic rhinosinusitis with nasal polyps and chronic obstructive pulmonary disease .

HY-P99413

IMAB027 Asp1650	HCV	Cancer
IMAB027 (ASP1650) is a specific anti-CLDN6 mAb, while CLDN6 (Claudin 6) is a tight junction membrane protein, aberrantly expressed in various human cancer types, ovarian cancers particularly. IMAB 027 shows anti-tumor activity, and induces apoptosis in CLDN6 ⁺ ovarian and testicular cancer cell lines .

HY-P991603

ASP5094	Integrin	Inflammation/Immunology
ASP5094 is a humanized monoclonal antibody against integrin alpha-9. ASP5094 has good safety and tolerability. ASP5094 can be used in the research of diseases such as rheumatoid arthritis .

HY-P991393

ASP8374	Transmembrane Glycoprotein IFNAR TNF Receptor	Cancer
ASP8374 is a human IgG4 monoclonal antibody (mAb) targeting TIGIT. ASP8374 increases IL-2 production in Jurkat cells and IFN-γ and TNF-α production in human PBMCs. ASP8374 can be used in advanced solid tumors research. Recommended isotype control: Human IgG4 kappa, Isotype Control (HY-P99003) .

HY-P991084

TQB-2858	PD-1/PD-L1	Cancer
TQB-2858 is a bifunctional fusion protein composed of a monoclonal antibody against PD-L1 fused with the extracellular domain of TGF-β receptor. TQB-2858 has a high affinity for PD-L1, TGF-β1, and TGF-β3 and exhibited high PD-L1 target occupancy. TQB-2858 can be used for the study of osteosarcoma and alveolar soft part sarcoma (ASPS) .

HY-P991329

ASP-1948	Complement System	Cancer
ASP-1948 is a human monoclonal antibody (mAb) targeting NRP1/VEGF165R/CD34. ASP-1948 reverses the suppressive effects of regulatory T cells. ASP-1948 can be used in solid tumors research .

HY-P991356

FAZ-053 LAE-005	PD-1/PD-L1	Cancer
FAZ-053 is a human monoclonal antibody (mAb) targeting B7-H1/PD-L1/CD274. FAZ-053 inhibits the interaction of PD-L1 with PD-1 and B7-1 on monocytes, dendritic cells, and B cells. FAZ-053 enhances interleukin 2 production. FAZ-053 can be used in advanced alveolar soft tissue sarcoma (ASPS), chordoma, and triple-negative breast cancer research .

HY-P992315

ASP1951 PTZ-522	TNF Receptor	Cancer
ASP1951 (PTZ-522) is a monoclonal antibody that targets GITR and is a GITR agonist. ASP1951 can be used for the research of advanced solid tumours .

HY-P992157

Anti-APP/Amyloid beta Antibody (3D6) murine version of Bapineuzumab	Amyloid-β	Neurological Disease
Anti-APP/Amyloid beta Antibody (3D6) is an antibody targeting β-amyloid protein (Aβ) containing free Asp1. Anti-APP/Amyloid beta Antibody (3D6) recognizes and binds to the amino acid epitope at positions 1-5 of β-amyloid protein with a free Asp1 residue. Anti-APP/Amyloid beta Antibody (3D6) serves as a detection antibody in immunoblot analysis. Anti-APP/Amyloid beta Antibody (3D6) is applicable to research related to Alzheimer's disease .

Cat. No.	Product Name	Chemical Structure

HY-12432S1

Gilteritinib-d8
Gilteritinib-d₈ is deuterium labeled Gilteritinib. Gilteritinib (ASP2215) is a potent and ATP-competitive FLT3/AXL inhibitor with IC50s of 0.29 nM/0.73 nM, respectively.

HY-Y0313S

p-Hydroxybenzaldehyde-d4
p-Hydroxybenzaldehyde-d₄ is the deuterium labeled p-Hydroxybenzaldehyde. p-Hydroxybenzaldehyde is a one of the major components in Dendrocalamus asper bamboo shoots, with antagonistic effect on GABAA receptor of the α1β2γ2S subtype at high concentrations.

HY-Y0313S1

p-Hydroxybenzaldehyde-13C
p-Hydroxybenzaldehyde- ¹³C is the ¹³C-labeled p-Hydroxybenzaldehyde. p-Hydroxybenzaldehyde is a one of the major components in Dendrocalamus asper bamboo shoots, with antagonistic effect on GABAA receptor of the α1β2γ2S subtype at high concentrations.

HY-Y1169S1

*Fmoc-Asp(OtBu)-OH-13C4,15N*
Fmoc-Asp(OtBu)-OH- ¹³C₄, ¹⁵N is the ¹³C and ¹⁵N labeled Fmoc-Asp(OtBu)-OH . Fmoc-Asp(OtBu)-OH (4-tert-Butyl N-(fluoren-9-ylmethoxycarbonyl)-L-aspartate) is a aspartate derivative containing amine protecting group Fmoc. Fmoc-Asp(OtBu)-OH can be used for peptide synthesis .

HY-Y1169S2

*Fmoc-Asp(OtBu)-OH-d3*
Fmoc-Asp(OtBu)-OH-d₃ (4-tert-Butyl N-(fluoren-9-ylmethoxycarbonyl)-L-aspartate-d₃) is deuterium labeled Fmoc-Asp(OtBu)-OH. Fmoc-Asp(OtBu)-OH (4-tert-Butyl N-(fluoren-9-ylmethoxycarbonyl)-L-aspartate) is a aspartate derivative containing amine protecting group Fmoc. Fmoc-Asp(OtBu)-OH can be used for peptide synthesis .

HY-14894S2

Pragliflozin-13C6
Pragliflozin- ¹³C₆ (ASP1941- ¹³C₆) is ¹³C labeled Ipragliflozin. Ipragliflozin (ASP1941) is an orally active and selective SGLT2 inhibitor with IC₅₀s of 7.38 and 1876 nM, 6.73 and 1166 nM, 5.64 and 1380 nM for human SGLT2 and SGLT1, rat SGLT2 and SGLT1, mouse SGLT2 and SGLT1, respectively. Antidiabetic agent .

HY-Y1169S

*Fmoc-Asp(OtBu)-OH-15N*
Fmoc-Asp(OtBu)-OH- ¹⁵N is the ¹⁵N-labeled Fmoc-Asp(OtBu)-OH (HY-Y1169). Fmoc-Asp(OtBu)-OH (4-tert-Butyl N-(fluoren-9-ylmethoxycarbonyl)-L-aspartate) is an aspartate derivative containing amine protecting group Fmoc. Fmoc-Asp(OtBu)-OH can be used for peptide synthesis .

HY-W013144S

*Fmoc-D-Asp(OtBu)-OH-13C4,15N*
Fmoc-D-Asp(OtBu)-OH- ¹³C₄, ¹⁵N is the ¹³C- and ¹⁵N-labeled Fmoc-D-Asp(OtBu)-OH (HY-W013144). Fmoc-D-Asp(OtBu)-OH is an aspartic acid derivative .

HY-19568S

Peficitinib-d3
Peficitinib-d₃ (ASP015K-d₃) is the deuterium labeled Peficitinib (HY-19568). Peficitinib (ASP015K) is an orally active JAK inhibitor, with IC₅₀s of 3.9, 5.0, 0.7 and 4.8 nM for JAK1, JAK2, JAK3 and Tyk2, respectively .

HY-W752451

Amenamevir-d6
Amenamevir-d₆ (ASP2151-d₆) is the deuterium labeled Amenamevir (HY-14809). Amenamevir is a helicase-primase inhibitor which has potent antiviral activity against HSVs with an EC₅₀ of 14 ng/mL.

Cat. No.	Product Name		Classification

HY-P10303

*Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)]* Cyclo[RGDfK(Azide)]		Azide
Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)] is the derivative of Cyclo(-RGDfK) (HY-P0023). Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)] is a click chemistry reagent containing an azide group. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity .

HY-175860

KRAS G12D ligand-Linker Conjugate 2		Alkynes
KRAS G12D ligand-Linker Conjugate 2 is a conjugate of the KRAS (G12D) ligand (HY-175859) and the linker (HY-168698). KRAS G12D ligand-Linker Conjugate 2 can be used for synthesizing PROTAC KRAS (G12D) degrader ASP-3082 (HY-157505) .

Cat. No.	Product Name		Classification

HY-113166

Dodecanoylcarnitine 1 Publications Verification (-)-Lauroylcarnitine		Cationic Lipids
Dodecanoylcarnitine ((-)-Lauroylcarnitine) is a medium long-chain acylcarnitine, an intermediate product in key energy metabolic pathways of fatty acid β-oxidation and amino acids catabolism. The abnormal decrease in the Dodecanoylcarnitine levels indicats that mitochondrial fuel metabolism, including fatty acid oxidation is significantly disturbed. Changes in plasma concentrations of Dodecanoylcarnitine are not only associated with type II diabetes, but also with pre-diabetes status. Dodecanoylcarnitine is present in fatty acid oxidation disorders such as long-chain acyl CoA dehydrogenase deficiency, carnitine palmitoyltransferase I/II deficiency, and is also associated with celiac disease. Dodecanoylcarnitine deomonstrates high sensitivities and specificities in predicting asthma. Combined model of Decanoylcarnitine (HY-113069), Dodecanoylcarnitine, PC (16:0/0:0), and Asp Arg Pro can be used as a potential biomarker for the diagnosis of Yin-deficiency-heat syndrome .

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