Ac-c[Cys-Glu-His-d-Phe-Arg-Trp-d-Cys]-Pro-Pro-Lys-Asp-NH2
Based on 1 Customer Validation
Ac-c-Pro-Pro-Lys-Asp-NH2 is a selective human melanocortin 5 receptor (hMC5R) antagonist with an IC50 of 10 nM.
For research use only. We do not sell to patients.
- Purity : 98.14%
- CAS No.: 596135-92-1
- Formula: C65H89N19O16S2
- Molecular Weight:1456.65
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Biological Activity
Description
IC50 & Target
[1]|
MC5R 10 nM (IC50) |
MC4R >10000 nM (IC50) |
MC3R 5600 nM (IC50) |
In Vitro
Ac-c[Cys-Glu-His-d-Phe-Arg-Trp-d-Cys]-Pro-Pro-Lys-Asp-NH2 (compound 5) (10-10 to 10-4 M; 40 min) shows 560-fold and >1000-fold selectivity for hMC5R over hMC3R and hMC4R, respectively[1].
Ac-c[Cys-Glu-His-d-Phe-Arg-Trp-d-Cys]-Pro-Pro-Lys-Asp-NH2 (10-10 to 10-4 M; 3 min) exhibits no stimulation of intracellular cAMP accumulation (EC50 >10,000 nM) in transfected HEK293 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 596135-92-1
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Appearance Solid
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Molecular Weight 1456.65
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Formula C65H89N19O16S2
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Color White to off-white
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Sequence
Ac-c[Cys-Glu-His-{d-Phe}-Arg-Trp-{d-Cys}]-Pro-Pro-Lys-Asp-NH2
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Sequence Shortening
Ac-c[CEH{d-F}-RW-{d-C}]-PPKD-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
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Data Sheet (260 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)