Ac-c[Cys-Glu-His-d-Phe-Arg-Trp-d-Cys]-Pro-Pro-Lys-Asp-NH2
Based on 1 Customer Validation
Ac-c-Pro-Pro-Lys-Asp-NH2 is a selective human melanocortin 5 receptor (hMC5R) antagonist with an IC50 of 10 nM.
For research use only. We do not sell to patients.
- Purity : 98.14%
- CAS No.: 596135-92-1
- Formula: C65H89N19O16S2
- Molecular Weight:1456.65
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Biological Activity
Description
IC50 & Target
[1]|
MC5R 10 nM (IC50) |
MC4R >10000 nM (IC50) |
MC3R 5600 nM (IC50) |
In Vitro
Ac-c[Cys-Glu-His-d-Phe-Arg-Trp-d-Cys]-Pro-Pro-Lys-Asp-NH2 (compound 5) (10-10 to 10-4 M; 40 min) shows 560-fold and >1000-fold selectivity for hMC5R over hMC3R and hMC4R, respectively[1].
Ac-c[Cys-Glu-His-d-Phe-Arg-Trp-d-Cys]-Pro-Pro-Lys-Asp-NH2 (10-10 to 10-4 M; 3 min) exhibits no stimulation of intracellular cAMP accumulation (EC50 >10,000 nM) in transfected HEK293 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 596135-92-1
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Appearance Solid
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Molecular Weight 1456.65
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Formula C65H89N19O16S2
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Color White to off-white
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Sequence
Ac-c[Cys-Glu-His-{d-Phe}-Arg-Trp-{d-Cys}]-Pro-Pro-Lys-Asp-NH2
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Sequence Shortening
Ac-c[CEH{d-F}-RW-{d-C}]-PPKD-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
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Data Sheet (260 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)