2. Metabolic Enzyme/Protease Neuronal Signaling
  3. FAAH
  4. ASP 8477

ASP 8477 is an orally active and selective fatty acid amide hydrolase (FAAH) inhibitor with IC50 values ​​of 3.99, 1.65, and 57.3 nM for human FAAH-1, FAAH-1 (P129T), and FAAH-2, respectively. ASP 8477 has central nervous system activity and can be used in analgesia research.

For research use only. We do not sell to patients.

ASP 8477

ASP 8477 Chemical Structure

CAS No. : 906737-25-5

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
25 mg In-stock
50 mg In-stock
100 mg In-stock
250 mg In-stock
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5 g   Get quote  
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ASP 8477 Related Antibodies

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Description

ASP 8477 is an orally active and selective fatty acid amide hydrolase (FAAH) inhibitor with IC50 values ​​of 3.99, 1.65, and 57.3 nM for human FAAH-1, FAAH-1 (P129T), and FAAH-2, respectively. ASP 8477 has central nervous system activity and can be used in analgesia research[1].

IC50 & Target[1]

FAAH-1

3.99 nM (IC50)

FAAH-1 (P129T)

1.65 nM (IC50)

FAAH-2

57.3 nM (IC50)

Clinical Trial
Molecular Weight

325.36

Formula

C18H19N3O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CCC(C(NC2=CC=CC=C2)=O)CC1)OC3=CC=CN=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (76.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0735 mL 15.3676 mL 30.7352 mL
5 mM 0.6147 mL 3.0735 mL 6.1470 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0735 mL 15.3676 mL 30.7352 mL 76.8380 mL
5 mM 0.6147 mL 3.0735 mL 6.1470 mL 15.3676 mL
10 mM 0.3074 mL 1.5368 mL 3.0735 mL 7.6838 mL
15 mM 0.2049 mL 1.0245 mL 2.0490 mL 5.1225 mL
20 mM 0.1537 mL 0.7684 mL 1.5368 mL 3.8419 mL
25 mM 0.1229 mL 0.6147 mL 1.2294 mL 3.0735 mL
30 mM 0.1025 mL 0.5123 mL 1.0245 mL 2.5613 mL
40 mM 0.0768 mL 0.3842 mL 0.7684 mL 1.9209 mL
50 mM 0.0615 mL 0.3074 mL 0.6147 mL 1.5368 mL
60 mM 0.0512 mL 0.2561 mL 0.5123 mL 1.2806 mL
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ASP 8477 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ASP 8477906737-25-5ASP8477ASP-8477FAAHFatty acid amide hydrolaseOral activitySelective inhibitorscentral nervous systemAnalgesiafatty acid amide hydrolaseInhibitorinhibitorinhibit

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