1. GPCR/G Protein
  2. Oxytocin Receptor
  3. [Asp5]-Oxytocin acetate

[Asp5]-Oxytocin acetate is the first 5-position neurohypophyseal hormone analogue possessing significant biological activity. [Asp5]-Oxytocin acetate causes uterine contractions in vitro, enhanced by Mg2+. [Asp5]-Oxytocin acetate has the ability of rat uteroconstrictor, avian vasodilator, and rat antidiuretic.

For research use only. We do not sell to patients.

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[Asp5]-Oxytocin acetate Chemical Structure

[Asp5]-Oxytocin acetate Chemical Structure

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  • Biological Activity

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Description

[Asp5]-Oxytocin acetate is the first 5-position neurohypophyseal hormone analogue possessing significant biological activity. [Asp5]-Oxytocin acetate causes uterine contractions in vitro, enhanced by Mg2+. [Asp5]-Oxytocin acetate has the ability of rat uteroconstrictor, avian vasodilator, and rat antidiuretic[1].

In Vitro

[Asp5]-Oxytocin acetate retains not only a high affinity for the uterotonic receptor, but also an intrinsic activity identical with that of oxytocin[1].
[Asp5]-Oxytocin acetate displays an increasing intrinsic activity enhanced by 1 mM Mg2+[1].
[Asp5]-Oxytocin acetate exerts the same potencies of rat uterotonic, avian vasodepressor, and rat antidiuretic with 20.3, 41, and 0.14 units/mg dose[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1068.22

Formula

C45H69N11O15S2

Appearance

Solid

Color

White to off-white

Sequence

Cys-Tyr-Ile-Gln-Asp-Cys-Pro-Leu-Gly-NH2 (Disulfide bridge:Cys1-Cys6)

Sequence Shortening

CYIQDCPLG-NH2 (Disulfide bridge:Cys1-Cys6)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Purity & Documentation
References
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[Asp5]-Oxytocin acetate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
[Asp5]-Oxytocin acetate
Cat. No.:
HY-P3217A
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