2. Cell Cycle/DNA Damage
  3. Deubiquitinase
  4. LC-U7-44

LC-U7-44 is a potent USP7 inhibitor with an IC50 of 0.96 μM. LC-U7-44 binds to the hydrophobic catalytic pocket of USP7, forming hydrogen bonds with Gln297, Arg408, Asp295, Val296, and Gln351, and hydrophobic interactions with Leu406. LC-U7-44 exerts anti-proliferative effects on prostate cancer cells. LC-U7-44 can be used for the research of prostate cancer.

For research use only. We do not sell to patients.

LC-U7-44

LC-U7-44 Chemical Structure

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LC-U7-44 Related Antibodies

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USP1 USP2 USP4 USP7 USP8 USP10 USP21 USP30 UCHL1 USP11 USP15

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Description

LC-U7-44 is a potent USP7 inhibitor with an IC50 of 0.96 μM. LC-U7-44 binds to the hydrophobic catalytic pocket of USP7, forming hydrogen bonds with Gln297, Arg408, Asp295, Val296, and Gln351, and hydrophobic interactions with Leu406. LC-U7-44 exerts anti-proliferative effects on prostate cancer cells. LC-U7-44 can be used for the research of prostate cancer[1].

IC50 & Target[1]

USP7

0.96 μM (IC50)

In Vitro

LC-U7-44 (10 μM; 20-30 min) potently inhibits purified USP7 protein with an IC50 of 0.96 μM in a fluorescence polarization binding assay[1].
LC-U7-44 potently inhibits the enzymatic activity of purified USP7 protein with an IC50 of 0.46 μM in a Ub-Rho assay[1].
LC-U7-44 (0.01-100 μM; 6 days) potently inhibits the proliferation of LNCaP cells with an IC50 of 1.83 μM following 6 days of treatment[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LC-U7-44 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: lymph node carcinoma of the prostate (LNCaP) cells
Concentration: 0.01-100 μM
Incubation Time: 6 days
Result: Suppressed LNCaP cell proliferation with an IC50 of 1.83 μM.
Molecular Weight

500.59

Formula

C28H32N6O3
SMILES

CN1N=C2C(N=CN(CC3(O)CCN(C(CCC4=CC=CC=C4)=O)CC3)C2=O)=C1C5=CC=C(CN)C=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LC-U7-44 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LC-U7-44DeubiquitinaseDUBsUSP7Asp295Leu406Arg408prostate cancer cellsLNCaP cellsGln297Ubiquitin-specific protease 7Gln351Val296Inhibitorinhibitorinhibit

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