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Cat. No.: HY-182437

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ASP4345 free base

ASP4345 free base is a blood-brain barrier-permeable dopamine D1 receptor modulator. ASP4345 free base binds to the allosteric site of the dopamine D1 receptor, thereby enhancing dopamine activity. ASP4345 free base can be used in the research of schizophrenia and Parkinson's disease.

For research use only. We do not sell to patients.

CAS No.: 1632257-75-0
Formula: C₁₉H₁₄ClF₃N₄O₃
Molecular Weight:438.79

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Please store the product under the recommended conditions in the Certificate of Analysis.

ASP4345 free base Chemical Structure

CAS No.: 1632257-75-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- Cellular Effect
Chemical Information
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Biological Activity

Description

All Dopamine Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	460 nM Compound: 25	Positive allosteric modulation of human D1R expressed in CHO cells assessed as 2-fold increase in dopamine-induced cAMP accumulation preincubated for 10 mins followed by dopamine addition and measured after 20 mins by fluorescence assay Positive allosteric modulation of human D1R expressed in CHO cells assessed as 2-fold increase in dopamine-induced cAMP accumulation preincubated for 10 mins followed by dopamine addition and measured after 20 mins by fluorescence assay	[PMID: 30525590]

Chemical Information

CAS No. 1632257-75-0
Molecular Weight 438.79
Formula C₁₉H₁₄ClF₃N₄O₃
SMILES

O=C1OC2=CC=C(C=C2N1CC(N(CC3=NC4=C(N3)C=C(C(F)(F)F)C=C4)C)=O)Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Verma M. Evaluating a Positive Allosteric Modulator Radiotracer Candidate to Image the Dopamine D1 Receptor. Université d'Ottawa| University of Ottawa, 2025.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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ASP4345 free base

All Dopamine Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

ASP4345 free base Related Classifications

HY-182437 Related Classifications