1. Membrane Transporter/Ion Channel
  2. SGLT
  3. Ipragliflozin

Ipragliflozin  (Synonyms: ASP1941)

Cat. No.: HY-14894 Purity: 99.78%
COA Handling Instructions

Ipragliflozin (ASP1941) is an orally active and selective SGLT2 inhibitor with IC50s of 7.38 and 1876 nM, 6.73 and 1166 nM, 5.64 and 1380 nM for human SGLT2 and SGLT1, rat SGLT2 and SGLT1, mouse SGLT2 and SGLT1, respectively. Antidiabetic agent.

For research use only. We do not sell to patients.

Ipragliflozin Chemical Structure

Ipragliflozin Chemical Structure

CAS No. : 761423-87-4

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
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Solid
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25 mg USD 66 In-stock
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500 mg USD 563 In-stock
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Customer Review

Based on 5 publication(s) in Google Scholar

Other Forms of Ipragliflozin:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Ipragliflozin (ASP1941) is an orally active and selective SGLT2 inhibitor with IC50s of 7.38 and 1876 nM, 6.73 and 1166 nM, 5.64 and 1380 nM for human SGLT2 and SGLT1, rat SGLT2 and SGLT1, mouse SGLT2 and SGLT1, respectively. Antidiabetic agent[1].

IC50 & Target[1]

hSGLT2

7.38 nM (IC50)

hSGLT1

1876 nM (IC50)

rSGLT2

6.73 nM (IC50)

rSGLT1

1166 nM (IC50)

mSGLT2

5.64 nM (IC50)

mSGLT1

1380 nM (IC50)

In Vitro

Ipragliflozin (1-50 μM) significantly and dose-dependently suppresses the growth of MCF-7 human breast cancer cell lines.
Upon knocking down SGLT2 expression using siRNA, the attenuation of cell proliferation induced by Ipragliflozin is completely canceled, suggesting that Ipragliflozin attenuates breast cancer cell proliferation through SGLT2 inhibition.
BrdU assay revealed that Ipragliflozin at a high dose (50 and 100 μM) significantly inhibits DNA synthesis of MCF-7 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: MCF-7 human breast cancer cell lines
Concentration: 1, 10, 50 μM
Incubation Time: 24, 48, 72, 96 hours
Result: Decreased the number of MCF-7 cells in a dose-dependent manner.
In Vivo

Ipragliflozin shows antihyperglycemic effect. Ipragliflozin (0.1-1 mg/kg) dose-dependently inhibits increases in blood glucose levels. In STZ-induced type 1 diabetic rats, this effect is significant at doses of 0.3 and 1 mg/kg, and in KK-Ay type 2 diabetic mice, the effect is significant at all tested doses[1].
Ipragliflozin (0.3 and 1 mg/kg) shows antidiabetic effects of repeated administration in streptozotocin-induced type 1 diabetic rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Single Administration[1]
Streptozotocin (STZ; 50 mg/kg)-induced type 1 diabetic rats and KK-Ay type 2 diabetic mice
Dosage: 0.1-1 mg/kg
Administration: Single oral administration in the fed condition. Blood glucose levels were then measured for 8 h under fasting conditions.
Result: Dose-dependently lowered blood glucose levels, and this effect was significant at all tested doses.
Animal Model: Repeated Administration[1]
Streptozotocin (STZ; 50 mg/kg)-induced type 1 diabetic rats
Dosage: 0.3 and 1 mg/kg
Administration: Administration orally once daily (at night) for 4 weeks.
Result: Significantly reduced the levels of HbA1c and blood glucose. Pancreatic insulin content was significantly increased at a dose of 1 mg/kg. Urinary glucose excretion was increased dose-dependently, and this was significant at the 1 mg/kg dose.
Clinical Trial
Molecular Weight

404.45

Formula

C21H21FO5S

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC1=CC=C([C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)C=C1CC3=CC(C=CC=C4)=C4S3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (247.25 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4725 mL 12.3625 mL 24.7249 mL
5 mM 0.4945 mL 2.4725 mL 4.9450 mL
10 mM 0.2472 mL 1.2362 mL 2.4725 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (6.18 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (6.18 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (6.18 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.78%

References
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Ipragliflozin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Ipragliflozin
Cat. No.:
HY-14894
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