1. Membrane Transporter/Ion Channel
  2. SGLT
  3. Ipragliflozin L-Proline

Ipragliflozin L-Proline 

Cat. No.: HY-14894A
Handling Instructions

Ipragliflozin (L-Proline) is a highly potent and selective SGLT2 inhibitor with an IC50 of 2.8 nM; little and NO potency for SGLT1/3/4/5/6.

For research use only. We do not sell to patients.

Ipragliflozin L-Proline Chemical Structure

Ipragliflozin L-Proline Chemical Structure

CAS No. : 951382-34-6

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Description

Ipragliflozin (L-Proline) is a highly potent and selective SGLT2 inhibitor with an IC50 of 2.8 nM; little and NO potency for SGLT1/3/4/5/6.

IC50 & Target

IC50 value: 2.8 nM (SGLT2)[1][2].

In Vitro

Ipragliflozin (L-Proline) potently and selectively inhibits human, rat, and mouse SGLT2 at nanomolar ranges and exhibits stability against intestinal glucosidases[3].

In Vivo

Ipragliflozin (L-Proline) shows good pharmacokinetic properties following oral dosing, and dose-dependently increases urinary glucose excretion, which lasts for over 12 h in normal mice [3]. Oral administration of ipragliflozin increases urinary glucose excretion in a dose-dependent manner, an effect which is significant at doses of 0.3 mg/kg or higher and lasts over 12 h[4]. Single administration of ipragliflozin dose-dependently increases urinary glucose excretion, reduces blood glucose and plasma insulin levels, and improves glucose intolerance [5].

Clinical Trial
Molecular Weight

519.58

Formula

C₂₆H₃₀FNO₇S

CAS No.

951382-34-6

SMILES

FC1=CC=C([[email protected]]2[[email protected]](O)[[email protected]@H](O)[[email protected]](O)[[email protected]@H](CO)O2)C=C1CC3=CC(C=CC=C4)=C4S3.O=C(O)[[email protected]]5NCCC5

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Product Name:
Ipragliflozin L-Proline
Cat. No.:
HY-14894A
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