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Referencia número: HY-P11552

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(Asp-Ser-Ser)6

Name: (Asp-Ser-Ser)6
Brand: MedChemExpress
SKU: HY-P11552
Price: 200.00 USD
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(Synonyms: (DSS)6)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

(Asp-Ser-Ser)6 ((DSS)6) is a synthetic bone-targeting peptide. (Asp-Ser-Ser)6 binds to hydroxyapatite and Ca²⁺ in mineralized tissues, preferentially binds to low-crystallinity hydroxyapatite in bone-forming regions, and localizes conjugated liposome-siRNA complexes to adjacent osteogenic areas. (Asp-Ser-Ser)6 can be used in research on osteoporosis and cranial defects.

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No. CAS: 929906-72-9
Fòrmula: C₆₀H₉₂N₁₈O₄₃
Peso molecular:1753.47

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Please store the product under the recommended conditions in the Certificate of Analysis.

(Asp-Ser-Ser)6 Chemical Structure

No. CAS: 929906-72-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- In Vitro
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Publications (1)
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Actividad biológica

Descripciòn

In Vitro

(Asp-Ser-Ser)6 ((DSS)6) (12 mg-10 h) is successfully synthesized into DSPE-PEG-(DSS)₆^[1] through amidation reaction with DSPE-PEG-COOH.
(Asp-Ser-Ser)6 (2 h) maintains a spherical, intact morphology and a size range similar to that of natural ApoEVs after DSPE-PEG-(DSS)₆ membrane modification^[1].
(Asp-Ser-Ser)6 (7-28 days) increases ALP and RUNX2 expression and mineralized nodule formation in OVX-derived BMSCs after osteogenic induction^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Chemical Information

No. CAS 929906-72-9
Peso molecular 1753.47
Fòrmula C₆₀H₉₂N₁₈O₄₃
Synonyms

(DSS)6
Sequence

Asp-Ser-Ser-Asp-Ser-Ser-Asp-Ser-Ser-Asp-Ser-Ser-Asp-Ser-Ser-Asp-Ser-Ser
Sequence Shortening

DSSDSSDSSDSSDSSDSS
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Genes (Basel)

2026 Sep 19;17(9):1148. PMID: 42793042

Pureza y Documentación

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Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Gui L, et al. Bone-Targeting Peptide and RNF146 Modified Apoptotic Extracellular Vesicles Alleviate Osteoporosis. International journal of nanomedicine. 2024;19:471-488. [Content Brief]

[2]. Gu Y, et al. Vitexin Alleviates Knee Osteoarthritis-Associated Cartilage Damage Associated with F3 Modulation. Genes. 2026 Sep 19;17(9):1148.

[3]. Xu G, et al. The construction of a novel xenograft bovine bone scaffold, (DSS)6-liposome/CKIP-1 siRNA/calcine bone and its osteogenesis evaluation on skull defect in rats. J Orthop Translat. 2021 Mar 2;28:74-82.

[4]. Liu J, et al. Bi-directionally selective bone targeting delivery for anabolic and antiresorptive drugs: a novel combined therapy for osteoporosis?. Medical hypotheses. 2014 Dec;83(6):694-6. [Content Brief]

[5]. Si K, et al. Binding mechanism and bioavailability of a novel phosvitin phosphopeptide (Glu-Asp-Asp-pSer-pSer) calcium complex. Food chemistry. 2023 Mar 15;404(Pt A):134567.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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(Asp-Ser-Ser)6

1 Cited Publications

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(Asp-Ser-Ser)6

Publications Citing Use of MedChemExpress (MCE) (Asp-Ser-Ser)6