929906-72-9
Chemical Structure
(Asp-Ser-Ser)6
Synonym(s): (DSS)6
- CAS No.: 929906-72-9
- Formula:C60H92N18O43
- Molecular Weight:1753.47
SMILES: O=C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(N[C@@H](CO)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(O)=O)N
Biological Activity: (Asp-Ser-Ser)6 ((DSS)6) is a synthetic bone-targeting peptide. (Asp-Ser-Ser)6 binds to hydroxyapatite and Ca2+ in mineralized tissues, preferentially binds to low-crystallinity hydroxyapatite in bone-forming regions, and localizes conjugated liposome-siRNA complexes to adjacent osteogenic areas. (Asp-Ser-Ser)6 can be used in research on osteoporosis and cranial defects[1][2][3][4].
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(Asp-Ser-Ser)6 | (Asp-Ser-Ser)6 ((DSS)6) is a synthetic bone-targeting peptide. (Asp-Ser-Ser)6 binds to hydroxyapatite and Ca2+ in mineralized tissues, preferentially binds to low-crystallinity hydroxyapatite in bone-forming regions, and localizes conjugated liposome-siRNA complexes to adjacent osteogenic areas. (Asp-Ser-Ser)6 can be used in research on osteoporosis and cranial defects. | |||||||||||||||||||||
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References
- [1]. Gui L, et al. Bone-Targeting Peptide and RNF146 Modified Apoptotic Extracellular Vesicles Alleviate Osteoporosis. International journal of nanomedicine. 2024;19:471-488. [Content Brief]
- [2]. Gu Y, et al. Vitexin Alleviates Knee Osteoarthritis-Associated Cartilage Damage Associated with F3 Modulation. Genes. 2026 Sep 19;17(9):1148.
- [3]. Xu G, et al. The construction of a novel xenograft bovine bone scaffold, (DSS)6-liposome/CKIP-1 siRNA/calcine bone and its osteogenesis evaluation on skull defect in rats. J Orthop Translat. 2021 Mar 2;28:74-82.
- [4]. Liu J, et al. Bi-directionally selective bone targeting delivery for anabolic and antiresorptive drugs: a novel combined therapy for osteoporosis?. Medical hypotheses. 2014 Dec;83(6):694-6. [Content Brief]
