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  4. Insulin aspart

Insulin aspart  (Synonyms: B28Asp; B28-Asp-insulin; INA-X 14; Insulin X 14)

Cat. No.: HY-108767 Purity: 95%
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Insulin aspart (B28Asp) is a rapid-acting h-Insulin (HY-P0035) analog. Insulin aspart induces a faster hypoglycemic effect. Insulin aspart can be used in diabetes-related research.

For research use only. We do not sell to patients.

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Insulin aspart

Insulin aspart Chemical Structure

CAS No. : 116094-23-6

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Description

Insulin aspart (B28Asp) is a rapid-acting h-Insulin (HY-P0035) analog. Insulin aspart induces a faster hypoglycemic effect. Insulin aspart can be used in diabetes-related research[1][2].

In Vivo

Insulin aspart (5 IU/kg; subcutaneous injection; once daily for 5 consecutive days) exerts a stable hypoglycemic effect in streptozotocin (HY-13753)-induced diabetic mice, and fails to induce significant phosphorylation of hepatic Akt[2].
Insulin aspart (5 IU/kg; subcutaneous injection; single dose) produces sustained and stable systemic hyperinsulinemia in both male and female non-diabetic mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (male, 6−8 weeks old, streptozotocin-induced diabetic)[2]
Dosage: 5 IU/kg
Administration: s.c.; once daily; 5 consecutive days
Result: Boosted plasma insulin levels in fed diabetic mice to 127.6 μIU/mL, with elevation persisting for only 2 h.
Caused a sharp decrease in blood glucose levels in fasted diabetic mice to 109.5 mg/dL at 1 h postinjection, indicating hypoglycemia risk.
Did not induce noticeable hepatic Akt phosphorylation.
Exhibited consistent glycemic control efficacy on Days 1, 2, and 5, with blood glucose-lowering effects comparable to oral casNP/insulin/C10 at 50 IU/kg but with a shorter duration of action.
Animal Model: (male, female, nondiabetic)[2]
Dosage: 5 IU/kg
Administration: s.c.; single dose
Result: In male nondiabetic mice, reached an initial insulin level of 2,053 μIU/mL at baseline, increased modestly to 2,429 μIU/mL at 15 min, then declined to 1,500−1,650 μIU/mL over 1 to 4 h before rising slightly to 1,801 μIU/mL at 8 h.
In female nondiabetic mice, peaked at 2,506 μIU/mL at 1 h, followed by a gradual decline, yet maintained elevated levels of 1,942 μIU/mL at 8 h.
Clinical Trial
Formula

C256H381N65O79S6
CAS No.
Appearance

Liquid

Color

Colorless to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at 4°C, do not freeze
Purity & Documentation

Purity: 95%

SDS (251 KB)

COA (231 KB)

Handling Instructions (2659 KB)
References
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Insulin aspart Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Insulin aspart116094-23-6B28Asp B28-Asp-insulin INA-X 14 Insulin X 14Insulin X14Insulin X 14Insulin X-14Insulin ReceptorDrug DerivativeDrug derivativeinsulin/IGF-1 receptorstreptozotocin-induced diabetic micenondiabetic micediabetes mellituspostprandial hyperglycemiahypoglycemic agentglucose-lowering agenthexamerization inhibitorinsulinotropic agentdiabetic miceInhibitorinhibitorinhibit

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