Fibronectin CS1 Peptide

Cat. No.: HY-P1816 Purity: 99.10%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

The connecting segment 1 (CS-1) is a cell attachment domain located in the type III homology connecting segment (IIICS) of fibronectin. Fibronectin CS1 Peptide lacks the Arg-Gly-Asp-containing domain, actively inhibits tumor metastases in spontaneous and experimental metastasis models.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Fibronectin CS1 Peptide Chemical Structure

CAS No. : 136466-51-8

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Integrin Isoform Specific Products:

View All Isoforms

αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	IC₅₀	824 μM Compound: 1	Antagonist activity at integrin alpha4beta1 receptor in human CCRF-CEM cells assessed as inhibition of cell adhesion to fibronectin after 1 hr by calcein AM staining-based fluorescence assay Antagonist activity at integrin alpha4beta1 receptor in human CCRF-CEM cells assessed as inhibition of cell adhesion to fibronectin after 1 hr by calcein AM staining-based fluorescence assay	10.1039/C1MD00229E

Molecular Weight

872.96

Formula

C₃₈H₆₄N₈O₁₅

CAS No.

136466-51-8

Appearance

Solid

Color

White to off-white

Sequence

Glu-Ile-Leu-Asp-Val-Pro-Ser-Thr

Sequence Shortening

EILDVPST

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (114.55 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1455 mL	5.7276 mL	11.4553 mL
5 mM	0.2291 mL	1.1455 mL	2.2911 mL
10 mM	0.1146 mL	0.5728 mL	1.1455 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.10%

Select Batch:

Data Sheet (272 KB) SDS (254 KB)

COA (251 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Saiki I, et al. Inhibition of lung metastasis by synthetic and recombinant fragments of human fibronectin with functional domains. Jpn J Cancer Res. 1990 Oct;81(10):1003-11. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.1455 mL	5.7276 mL	11.4553 mL	28.6382 mL
	5 mM	0.2291 mL	1.1455 mL	2.2911 mL	5.7276 mL
	10 mM	0.1146 mL	0.5728 mL	1.1455 mL	2.8638 mL
	15 mM	0.0764 mL	0.3818 mL	0.7637 mL	1.9092 mL
	20 mM	0.0573 mL	0.2864 mL	0.5728 mL	1.4319 mL
	25 mM	0.0458 mL	0.2291 mL	0.4582 mL	1.1455 mL
	30 mM	0.0382 mL	0.1909 mL	0.3818 mL	0.9546 mL
	40 mM	0.0286 mL	0.1432 mL	0.2864 mL	0.7160 mL
	50 mM	0.0229 mL	0.1146 mL	0.2291 mL	0.5728 mL
	60 mM	0.0191 mL	0.0955 mL	0.1909 mL	0.4773 mL
	80 mM	0.0143 mL	0.0716 mL	0.1432 mL	0.3580 mL
	100 mM	0.0115 mL	0.0573 mL	0.1146 mL	0.2864 mL