Ac-Tyr-Val-Lys-Asp-aldehyde
Based on 1 Customer Validation
Ac-Tyr-Val-Lys-Asp-aldehyde is a reversible caspase-1 inhibitor. Ac-Tyr-Val-Lys-Asp-aldehyde increases GATA1 levels by inhibiting caspase-1 and promotes erythroid differentiation. can be used for disease research including anemia-associated to chronic diseases, chemotherapy-induced anemia and Diamond-Blackfan anemia.
For research use only. We do not sell to patients.
- Purity: 99.89%
- CAS No.: 147821-01-0
- Formula: C26H39N5O8
- Molecular Weight:549.62
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Caspase Isoforms
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Biological Activity
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Caspase-1 |
Ac-Tyr-Val-Lys-Asp-aldehyde can inhibit caspase-1, leading to an increase in GATA1 mRNA and protein levels, as well as enhanced expression of GYPA, TFRC, and SLC4A1 in CD34+ hematopoietic stem cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 147821-01-0
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Appearance Solid
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Molecular Weight 549.62
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Formula C26H39N5O8
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Color White to off-white
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Sequence Shortening
{Ac}-YVKD-CHO
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 62.5 mg/mL (113.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8194 mL | 9.0972 mL | 18.1944 mL | 45.4860 mL |
| 5 mM | 0.3639 mL | 1.8194 mL | 3.6389 mL | 9.0972 mL | |
| 10 mM | 0.1819 mL | 0.9097 mL | 1.8194 mL | 4.5486 mL | |
| 15 mM | 0.1213 mL | 0.6065 mL | 1.2130 mL | 3.0324 mL | |
| 20 mM | 0.0910 mL | 0.4549 mL | 0.9097 mL | 2.2743 mL | |
| 25 mM | 0.0728 mL | 0.3639 mL | 0.7278 mL | 1.8194 mL | |
| 30 mM | 0.0606 mL | 0.3032 mL | 0.6065 mL | 1.5162 mL | |
| 40 mM | 0.0455 mL | 0.2274 mL | 0.4549 mL | 1.1371 mL | |
| 50 mM | 0.0364 mL | 0.1819 mL | 0.3639 mL | 0.9097 mL | |
| 60 mM | 0.0303 mL | 0.1516 mL | 0.3032 mL | 0.7581 mL | |
| 80 mM | 0.0227 mL | 0.1137 mL | 0.2274 mL | 0.5686 mL | |
| 100 mM | 0.0182 mL | 0.0910 mL | 0.1819 mL | 0.4549 mL |
Ac-Tyr-Val-Lys-Asp-aldehyde Related Classifications
HY-P3761 Related Classifications
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