2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. ASP7663

ASP7663 

Cat. No.: HY-101907 Purity: 99.16%
COA Handling Instructions

ASP7663 is an orally active and selective TRPA1 agonist. ASP7663 exerts both anti-constipation and anti-abdominal pain actions.

For research use only. We do not sell to patients.

ASP7663 Chemical Structure

ASP7663 Chemical Structure

CAS No. : 1190217-35-6

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 151 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 151 In-stock
Solid
1 mg USD 52 In-stock
5 mg USD 110 In-stock
10 mg USD 176 In-stock
25 mg USD 330 In-stock
50 mg USD 528 In-stock
100 mg USD 770 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

ASP7663 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE ASP7663

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TRPC TRPM TRPV TRPA TRPML

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Description

ASP7663 is an orally active and selective TRPA1 agonist. ASP7663 exerts both anti-constipation and anti-abdominal pain actions[1][2].

In Vitro

ASP7663 concentration dependently increases intracellular Ca2+ concentration in human, rat, and mouse TRPA1 expressed in HEK293 cells in a similar manner, with respective EC50 values (95% confidence interval [CI]) of 0.51 (0.40–0.66), 0.54 (0.41–0.72), and 0.50 (0.41–0.63) μmol/L[1].
ASP7663 concentration-dependently stimulates 5-HT release from QGP-1 cells, a lineage of TRPA1-expressing EC cells, with an EC50 value of 72.5 (52.6–99.9) μmol/L[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ASP7663 Related Antibodies
In Vivo

ASP7663 significantly improves the loperamide-induced delay in colonic transit in mice[1].
ASP7663 (orally, 0.3 and 1 mg/kg) significantly shortens the prolonged bead expulsion time caused by loperamide[1].
ASP7663 (orally, 1 and 3 mg/kg) exhibits inhibitory effects on colorectal distension in rat[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CRD model (colorectal distension in rat)[1].
Dosage: 1 and 3 mg/kg.
Administration: Orally.
Result: Significantly reduced the number of abdominal contractions evoked during CRD at pressures of 30, 45, and 60 mmHg. ASP7663 also reduced the number of abdominal contractions by intravenous treatment.
Molecular Weight

263.26

Appearance

Solid

Formula

C14H14FNO3
CAS No.
SMILES

O=C(O)/C=C1C(N(CC(C)C)C2=C/1C=CC=C2F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (189.93 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7985 mL 18.9926 mL 37.9853 mL
5 mM 0.7597 mL 3.7985 mL 7.5971 mL
10 mM 0.3799 mL 1.8993 mL 3.7985 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (7.90 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (7.90 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.16%

COA (254 KB) HNMR (200 KB) LCMS (119 KB)

Handling Instructions (2659 KB)
References
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ASP7663 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

ASP76631190217-35-6ASP 7663ASP-7663TRP ChannelTransient receptor potential channelspainInhibitorinhibitorinhibit

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