Apoptosis inducer 57
Apoptosis inducer 57 is a apoptosis inducer and Thymidylate Synthase (TS) inhibitor. Apoptosis inducer 57 exhibits cytotoxic activity against SW480 and MCF-7 cancer cells with IC50 values of 15.7 and 16.5 µM, and induces dose-dependent apoptosis and S-phase cell cycle arrest. Apoptosis inducer 57 stalely binds the TS active site via interactions with Asp218 and Met311. TS-IN-9 can be used for breast cancer and colorectal cancer research.
For research use only. We do not sell to patients.
- Formula: C17H21FN4O2
- Molecular Weight:332.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Apoptosis inducer 57 (compound 5h) (0-32 μM, 72 h) effectively reduces cancer cell survival by inducing apoptosis in MCF-7 cells in a dose-dependent manner[1].
Apoptosis inducer 57 (0-32 μM, 72 h) induced significant cell cycle arrest at the S phase by reducing the G0/G1 population in MCF-7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 cells
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Concentration:0, 8, 16, and 32 µM
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Incubation Time:72 h
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Result:Elevated apoptosis to approximately 35% at 8 µM, reaching 48% and 62% at 16 µM and 32 µM, respectively.
Revealed a pronounced increase in late apoptosis at higher concentrations.
Induced a more pronounced S-phase arrest at higher concentrations, while concomitantly reducing the G2/M population.
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Cell Line:MCF-7 cells
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Concentration:0, 8, 16, and 32 µM
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Incubation Time:72 h
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Result:Increased the percentage of cells in the S phase at 8, 16, and 32 µM to 45.14%, 51.91%, and 58.48%, respectively.
Chemical Information
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Molecular Weight 332.37
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Formula C17H21FN4O2
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SMILES
CN1C(C=C(N(C1=O)CC2=CC=C(F)C=C2)N3CCC(CC3)N)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Baziar L, et al. Design, synthesis, and biological evaluation of novel 6-(4-aminopiperidin-1-yl)-substituted benzyl-3-methylpyrimidine-2,4(1H,3H)-dione derivatives as potential anticancer agents targeting thymidylate synthase. Sci Rep. 2025 Nov 20;15(1):40991. doi: 10.1038/s41598-025-24828-5 [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Apoptosis inducer 57 Related Classifications
HY-180537 Related Classifications
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