2. Apoptosis
  3. Apoptosis
  4. Apoptosis inducer 57

Apoptosis inducer 57 is a apoptosis inducer and Thymidylate Synthase (TS) inhibitor. Apoptosis inducer 57 exhibits cytotoxic activity against SW480 and MCF-7 cancer cells with IC50 values of 15.7 and 16.5 µM, and induces dose-dependent apoptosis and S-phase cell cycle arrest. Apoptosis inducer 57 stalely binds the TS active site via interactions with Asp218 and Met311. TS-IN-9 can be used for breast cancer and colorectal cancer research.

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Apoptosis inducer 57

Apoptosis inducer 57 Chemical Structure

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Description

Apoptosis inducer 57 is a apoptosis inducer and Thymidylate Synthase (TS) inhibitor. Apoptosis inducer 57 exhibits cytotoxic activity against SW480 and MCF-7 cancer cells with IC50 values of 15.7 and 16.5 µM, and induces dose-dependent apoptosis and S-phase cell cycle arrest. Apoptosis inducer 57 stalely binds the TS active site via interactions with Asp218 and Met311. TS-IN-9 can be used for breast cancer and colorectal cancer research[1].

In Vitro

Apoptosis inducer 57 (compound 5h) (0-32 μM, 72 h) effectively reduces cancer cell survival by inducing apoptosis in MCF-7 cells in a dose-dependent manner[1].
Apoptosis inducer 57 (0-32 μM, 72 h) induced significant cell cycle arrest at the S phase by reducing the G0/G1 population in MCF-7 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis inducer 57 Related Antibodies

Apoptosis Analysis[1]

Cell Line: MCF-7 cells
Concentration: 0, 8, 16, and 32 µM
Incubation Time: 72 h
Result: Elevated apoptosis to approximately 35% at 8 µM, reaching 48% and 62% at 16 µM and 32 µM, respectively.
Revealed a pronounced increase in late apoptosis at higher concentrations.
Induced a more pronounced S-phase arrest at higher concentrations, while concomitantly reducing the G2/M population.

Cell Cycle Analysis[1]

Cell Line: MCF-7 cells
Concentration: 0, 8, 16, and 32 µM
Incubation Time: 72 h
Result: Increased the percentage of cells in the S phase at 8, 16, and 32 µM to 45.14%, 51.91%, and 58.48%, respectively.
Molecular Weight

332.37

Formula

C17H21FN4O2
SMILES

CN1C(C=C(N(C1=O)CC2=CC=C(F)C=C2)N3CCC(CC3)N)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Apoptosis inducer 57 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apoptosis inducer 57Apoptosis inducer57Apoptosis inducer-57ApoptosisTSapoptosisS-phase cell cycle arrestbreast cancer and colorectal cancer researchInhibitorinhibitorinhibit

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